ARHGEF15 in Sertoli cells contributes to germ cell development and testicular immune privilege

Sertoli cells (SCs), the only somatic cells in the seminiferous tubules, facilitate the maintenance of testicular immune privilege through the formation of the blood-testis barrier (BTB) and the expression of immunoregulatory factors. Rho guanosine exchange factor 15 (ARHGEF15) is a member of the gu...

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Veröffentlicht in:	Biology of reproduction 2022-12, Vol.107 (6), p.1565-1579
Hauptverfasser:	Chen, Feng, Wu, Yingjie, Ke, Lu, Lin, Xinyi, Wang, Fengchao, Qin, Yinghe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arhgef15 Autoantigens Cell activation Cell cycle Cell migration Epididymis Germ cells Guanosine - metabolism Homeostasis Immune Privilege Immunoreactivity Immunoregulation Immunoregulatory factors knockout Localization Male Mice Mice, Knockout RESEARCH ARTICLE Semen Sequence analysis Sertoli cells Sertoli Cells - metabolism Somatic cells Sperm Spermatids Spermatogenesis Spermatogenesis - physiology Spermatozoa - metabolism Testes testicular immune privilege Testis - metabolism Tubules Ultrastructure
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