Effect of low-level light therapy before radiotherapy in oral squamous cell carcinoma: An in vitro study
Radiation therapy for head and neck squamous cell carcinoma (HNSCC) is associated with several complications. Although photobiomodulation (PBM) has radioprotective effects in normal tissue, it could also enhance the growth of neoplastic cells. Thus, the present study aimed to investigate the cellula...
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| Veröffentlicht in: | Lasers in medical science 2022-12, Vol.37 (9), p.3527-3536 |
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| creator | Tabosa, Angeliny Tamiarana Lima Souza, Marcela Gonçalves de Jesus, Sabrina Ferreira Rocha, Danielle Ferreira Queiroz, Lorena dos Reis Pereira Santos, Eloá Mangabeira Guimarães, Victor Hugo Dantas Andrade, Luciano Alves de Araújo Santos, Sérgio Henrique de Paula, Alfredo Maurício Batista de Souza, Paulo Eduardo Narcizo Farias, Lucyana Conceição Guimarães, André Luiz Sena |
| description | Radiation therapy for head and neck squamous cell carcinoma (HNSCC) is associated with several complications. Although photobiomodulation (PBM) has radioprotective effects in normal tissue, it could also enhance the growth of neoplastic cells. Thus, the present study aimed to investigate the cellular response of oral squamous cell carcinoma with pre-exposure to low-level phototherapy before radiotherapy. SCC9, Cal-27, A431, and HaCaT cell lines were subjected to low-level light therapy and radiotherapy. The cells were treated with a single energy density (300 J/cm
2
) of a light-emitting diode (660 nm) prior to ionizing radiation at different doses (0, 2, 4, and 6 Gy). After 24 h, wound scratch, proliferation, clonogenic cell survival, cell death, and reactive oxygen species (ROS) analyses were performed to evaluate cell response. The cell lines pre-exposed to PBM at the analyzed dosage were radiosensitive. The treatment significantly reduced cell proliferation and clonogenic cell survival. Migration and cell death assays also revealed positive results, with the treatment group showing lower rate of migration and higher cell death than did the control group. Moreover, PBM effectively increased the intracellular levels of ROS. PBM at 300 J/cm
2
is a promising radiosensitizing modality to reduce the radiation dose and avoid the intolerable side effects of radiotherapy for HNSCC, thus increasing the probability of successful treatment. However, further studies are needed to support and confirm the results. |
| doi_str_mv | 10.1007/s10103-022-03632-x |
| format | Article |
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2
) of a light-emitting diode (660 nm) prior to ionizing radiation at different doses (0, 2, 4, and 6 Gy). After 24 h, wound scratch, proliferation, clonogenic cell survival, cell death, and reactive oxygen species (ROS) analyses were performed to evaluate cell response. The cell lines pre-exposed to PBM at the analyzed dosage were radiosensitive. The treatment significantly reduced cell proliferation and clonogenic cell survival. Migration and cell death assays also revealed positive results, with the treatment group showing lower rate of migration and higher cell death than did the control group. Moreover, PBM effectively increased the intracellular levels of ROS. PBM at 300 J/cm
2
is a promising radiosensitizing modality to reduce the radiation dose and avoid the intolerable side effects of radiotherapy for HNSCC, thus increasing the probability of successful treatment. However, further studies are needed to support and confirm the results.</description><identifier>ISSN: 1435-604X</identifier><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-022-03632-x</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Apoptosis ; Cancer ; Cell death ; Cell migration ; Cell proliferation ; Cell survival ; Complications ; Dentistry ; Head & neck cancer ; Head and neck carcinoma ; Intracellular levels ; Ionizing radiation ; Lasers ; Light emitting diodes ; Light therapy ; Medicine ; Medicine & Public Health ; Mortality ; Optical Devices ; Optics ; Oral cancer ; Oral carcinoma ; Oral squamous cell carcinoma ; Original Article ; Photonics ; Phototherapy ; Quantum Optics ; Radiation dosage ; Radiation therapy ; Reactive oxygen species ; Side effects ; Squamous cell carcinoma ; Survival</subject><ispartof>Lasers in medical science, 2022-12, Vol.37 (9), p.3527-3536</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-ebaf119fac297e818b6519ba4bf75224d27c6e424ff4a0af6ee2d7f94ab072933</citedby><cites>FETCH-LOGICAL-c352t-ebaf119fac297e818b6519ba4bf75224d27c6e424ff4a0af6ee2d7f94ab072933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-022-03632-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-022-03632-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Tabosa, Angeliny Tamiarana Lima</creatorcontrib><creatorcontrib>Souza, Marcela Gonçalves</creatorcontrib><creatorcontrib>de Jesus, Sabrina Ferreira</creatorcontrib><creatorcontrib>Rocha, Danielle Ferreira</creatorcontrib><creatorcontrib>Queiroz, Lorena dos Reis Pereira</creatorcontrib><creatorcontrib>Santos, Eloá Mangabeira</creatorcontrib><creatorcontrib>Guimarães, Victor Hugo Dantas</creatorcontrib><creatorcontrib>Andrade, Luciano Alves de Araújo</creatorcontrib><creatorcontrib>Santos, Sérgio Henrique</creatorcontrib><creatorcontrib>de Paula, Alfredo Maurício Batista</creatorcontrib><creatorcontrib>de Souza, Paulo Eduardo Narcizo</creatorcontrib><creatorcontrib>Farias, Lucyana Conceição</creatorcontrib><creatorcontrib>Guimarães, André Luiz Sena</creatorcontrib><title>Effect of low-level light therapy before radiotherapy in oral squamous cell carcinoma: An in vitro study</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><description>Radiation therapy for head and neck squamous cell carcinoma (HNSCC) is associated with several complications. Although photobiomodulation (PBM) has radioprotective effects in normal tissue, it could also enhance the growth of neoplastic cells. Thus, the present study aimed to investigate the cellular response of oral squamous cell carcinoma with pre-exposure to low-level phototherapy before radiotherapy. SCC9, Cal-27, A431, and HaCaT cell lines were subjected to low-level light therapy and radiotherapy. The cells were treated with a single energy density (300 J/cm
2
) of a light-emitting diode (660 nm) prior to ionizing radiation at different doses (0, 2, 4, and 6 Gy). After 24 h, wound scratch, proliferation, clonogenic cell survival, cell death, and reactive oxygen species (ROS) analyses were performed to evaluate cell response. The cell lines pre-exposed to PBM at the analyzed dosage were radiosensitive. The treatment significantly reduced cell proliferation and clonogenic cell survival. Migration and cell death assays also revealed positive results, with the treatment group showing lower rate of migration and higher cell death than did the control group. Moreover, PBM effectively increased the intracellular levels of ROS. PBM at 300 J/cm
2
is a promising radiosensitizing modality to reduce the radiation dose and avoid the intolerable side effects of radiotherapy for HNSCC, thus increasing the probability of successful treatment. However, further studies are needed to support and confirm the results.</description><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Cell survival</subject><subject>Complications</subject><subject>Dentistry</subject><subject>Head & neck cancer</subject><subject>Head and neck carcinoma</subject><subject>Intracellular levels</subject><subject>Ionizing radiation</subject><subject>Lasers</subject><subject>Light emitting diodes</subject><subject>Light therapy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Oral cancer</subject><subject>Oral carcinoma</subject><subject>Oral squamous cell carcinoma</subject><subject>Original Article</subject><subject>Photonics</subject><subject>Phototherapy</subject><subject>Quantum Optics</subject><subject>Radiation dosage</subject><subject>Radiation therapy</subject><subject>Reactive oxygen species</subject><subject>Side effects</subject><subject>Squamous cell carcinoma</subject><subject>Survival</subject><issn>1435-604X</issn><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE1Lw0AQhoMoWKt_wNOCFy_Rnd3tbuKtlPoBBS8K3pZNOtumJNl2N6ntvzc1iuLB0wzD8w4vTxRdAr0BStVtAAqUx5SxmHLJWbw7igYg-CiWVLwd_9pPo7MQVpSCksAH0XJqLeYNcZaU7j0ucYslKYvFsiHNEr1Z70mG1nkk3swL930rauK8KUnYtKZybSA5liXJjc-L2lXmjozrA7MtGu9IaNr5_jw6saYMePE1h9Hr_fRl8hjPnh-eJuNZnPMRa2LMjAVIrclZqjCBJJMjSDMjMqtGjIk5U7lEwYS1wlBjJSKbK5sKk1HFUs6H0XX_d-3dpsXQ6KoIh3amxq6oZopKSABk0qFXf9CVa33dtesoAcBBqrSjWE_l3oXg0eq1Lyrj9xqoPsjXvXzdydef8vWuC_E-FDq4XqD_ef1P6gNvLYjQ</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Tabosa, Angeliny Tamiarana Lima</creator><creator>Souza, Marcela 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Henrique</au><au>de Paula, Alfredo Maurício Batista</au><au>de Souza, Paulo Eduardo Narcizo</au><au>Farias, Lucyana Conceição</au><au>Guimarães, André Luiz Sena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of low-level light therapy before radiotherapy in oral squamous cell carcinoma: An in vitro study</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>37</volume><issue>9</issue><spage>3527</spage><epage>3536</epage><pages>3527-3536</pages><issn>1435-604X</issn><issn>0268-8921</issn><eissn>1435-604X</eissn><abstract>Radiation therapy for head and neck squamous cell carcinoma (HNSCC) is associated with several complications. Although photobiomodulation (PBM) has radioprotective effects in normal tissue, it could also enhance the growth of neoplastic cells. Thus, the present study aimed to investigate the cellular response of oral squamous cell carcinoma with pre-exposure to low-level phototherapy before radiotherapy. SCC9, Cal-27, A431, and HaCaT cell lines were subjected to low-level light therapy and radiotherapy. The cells were treated with a single energy density (300 J/cm
2
) of a light-emitting diode (660 nm) prior to ionizing radiation at different doses (0, 2, 4, and 6 Gy). After 24 h, wound scratch, proliferation, clonogenic cell survival, cell death, and reactive oxygen species (ROS) analyses were performed to evaluate cell response. The cell lines pre-exposed to PBM at the analyzed dosage were radiosensitive. The treatment significantly reduced cell proliferation and clonogenic cell survival. Migration and cell death assays also revealed positive results, with the treatment group showing lower rate of migration and higher cell death than did the control group. Moreover, PBM effectively increased the intracellular levels of ROS. PBM at 300 J/cm
2
is a promising radiosensitizing modality to reduce the radiation dose and avoid the intolerable side effects of radiotherapy for HNSCC, thus increasing the probability of successful treatment. However, further studies are needed to support and confirm the results.</abstract><cop>London</cop><pub>Springer London</pub><doi>10.1007/s10103-022-03632-x</doi><tpages>10</tpages></addata></record> |
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| subjects | Apoptosis Cancer Cell death Cell migration Cell proliferation Cell survival Complications Dentistry Head & neck cancer Head and neck carcinoma Intracellular levels Ionizing radiation Lasers Light emitting diodes Light therapy Medicine Medicine & Public Health Mortality Optical Devices Optics Oral cancer Oral carcinoma Oral squamous cell carcinoma Original Article Photonics Phototherapy Quantum Optics Radiation dosage Radiation therapy Reactive oxygen species Side effects Squamous cell carcinoma Survival |
| title | Effect of low-level light therapy before radiotherapy in oral squamous cell carcinoma: An in vitro study |
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