Cholesterol accumulation in hepatocytes mediates IRE1/p38 branch of endoplasmic reticulum stress to promote nonalcoholic steatohepatitis

Non-alcoholic fatty liver disease (NAFLD), based on the elevating obesity incidence, is one of the major health issue worldwide. Transition from NAFLD to non-alcoholic steatohepatitis (NASH) is driven by increased apoptosis and is relevant to higher morbidity rates. In regard to limited understandin...

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Veröffentlicht in:	Free radical biology & medicine 2022-10, Vol.191, p.1-7
Hauptverfasser:	Sozen, Erdi, Demirel-Yalciner, Tugce, Sari, Dyana, Ozer, Nesrin Kartal
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cholesterol Endoplasmic reticulum stress NASH α-Tocopherol
Online-Zugang:	Volltext
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