Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas
Abstract Diffuse spinal cord gliomas (SCGs) are rare tumors associated with a high morbidity and mortality that affect both pediatric and adult populations. In this retrospective study, we sought to characterize the clinical, pathological, and molecular features of diffuse SCG in 22 patients with hi...
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| Veröffentlicht in: | Journal of neuropathology and experimental neurology 2022-10, Vol.81 (11), p.865-872 |
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| creator | Garcia, Mekka R Feng, Yang Vasudevaraja, Varshini Galbraith, Kristyn Serrano, Jonathan Thomas, Cheddhi Radmanesh, Alireza Hidalgo, Eveline T Harter, David H Allen, Jeffrey C Gardner, Sharon L Osorio, Diana S William, Christopher M Zagzag, David Boué, Daniel R Snuderl, Matija |
| description | Abstract
Diffuse spinal cord gliomas (SCGs) are rare tumors associated with a high morbidity and mortality that affect both pediatric and adult populations. In this retrospective study, we sought to characterize the clinical, pathological, and molecular features of diffuse SCG in 22 patients with histological and molecular analyses. The median age of our cohort was 23.64 years (range 1–82) and the overall median survival was 397 days. K27M mutation was significantly more prevalent in males compared to females. Gross total resection and chemotherapy were associated with improved survival, compared to biopsy and no chemotherapy. While there was no association between tumor grade, K27M status (p = 0.366) or radiation (p = 0.772), and survival, males showed a trend toward shorter survival. K27M mutant tumors showed increased chromosomal instability and a distinct DNA methylation signature. |
| doi_str_mv | 10.1093/jnen/nlac075 |
| format | Article |
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Diffuse spinal cord gliomas (SCGs) are rare tumors associated with a high morbidity and mortality that affect both pediatric and adult populations. In this retrospective study, we sought to characterize the clinical, pathological, and molecular features of diffuse SCG in 22 patients with histological and molecular analyses. The median age of our cohort was 23.64 years (range 1–82) and the overall median survival was 397 days. K27M mutation was significantly more prevalent in males compared to females. Gross total resection and chemotherapy were associated with improved survival, compared to biopsy and no chemotherapy. While there was no association between tumor grade, K27M status (p = 0.366) or radiation (p = 0.772), and survival, males showed a trend toward shorter survival. K27M mutant tumors showed increased chromosomal instability and a distinct DNA methylation signature.</description><identifier>ISSN: 0022-3069</identifier><identifier>EISSN: 1554-6578</identifier><identifier>DOI: 10.1093/jnen/nlac075</identifier><language>eng</language><publisher>Cary: Oxford University Press</publisher><subject>Adults ; Biopsy ; Brain cancer ; Chemotherapy ; DNA methylation ; Genetic testing ; Genomes ; Glioma ; Histology ; Hospitals ; Laboratories ; Medical prognosis ; Mutation ; Pathology ; Pediatrics ; Radiation ; Spinal cord ; Surgery ; Tumors</subject><ispartof>Journal of neuropathology and experimental neurology, 2022-10, Vol.81 (11), p.865-872</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of American Association of Neuropathologists, Inc. All rights reserved. For permissions, please email: journals.permissions@oup.com 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of American Association of Neuropathologists, Inc. All rights reserved. For permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c323t-ad2a907b9cc3e2a38ed066b33369b7afe36140b9555147cb389fc5cd79cb5a023</cites><orcidid>0000-0003-0752-0917</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1583,27923,27924</link.rule.ids></links><search><creatorcontrib>Garcia, Mekka R</creatorcontrib><creatorcontrib>Feng, Yang</creatorcontrib><creatorcontrib>Vasudevaraja, Varshini</creatorcontrib><creatorcontrib>Galbraith, Kristyn</creatorcontrib><creatorcontrib>Serrano, Jonathan</creatorcontrib><creatorcontrib>Thomas, Cheddhi</creatorcontrib><creatorcontrib>Radmanesh, Alireza</creatorcontrib><creatorcontrib>Hidalgo, Eveline T</creatorcontrib><creatorcontrib>Harter, David H</creatorcontrib><creatorcontrib>Allen, Jeffrey C</creatorcontrib><creatorcontrib>Gardner, Sharon L</creatorcontrib><creatorcontrib>Osorio, Diana S</creatorcontrib><creatorcontrib>William, Christopher M</creatorcontrib><creatorcontrib>Zagzag, David</creatorcontrib><creatorcontrib>Boué, Daniel R</creatorcontrib><creatorcontrib>Snuderl, Matija</creatorcontrib><title>Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas</title><title>Journal of neuropathology and experimental neurology</title><description>Abstract
Diffuse spinal cord gliomas (SCGs) are rare tumors associated with a high morbidity and mortality that affect both pediatric and adult populations. In this retrospective study, we sought to characterize the clinical, pathological, and molecular features of diffuse SCG in 22 patients with histological and molecular analyses. The median age of our cohort was 23.64 years (range 1–82) and the overall median survival was 397 days. K27M mutation was significantly more prevalent in males compared to females. Gross total resection and chemotherapy were associated with improved survival, compared to biopsy and no chemotherapy. While there was no association between tumor grade, K27M status (p = 0.366) or radiation (p = 0.772), and survival, males showed a trend toward shorter survival. K27M mutant tumors showed increased chromosomal instability and a distinct DNA methylation signature.</description><subject>Adults</subject><subject>Biopsy</subject><subject>Brain cancer</subject><subject>Chemotherapy</subject><subject>DNA methylation</subject><subject>Genetic testing</subject><subject>Genomes</subject><subject>Glioma</subject><subject>Histology</subject><subject>Hospitals</subject><subject>Laboratories</subject><subject>Medical prognosis</subject><subject>Mutation</subject><subject>Pathology</subject><subject>Pediatrics</subject><subject>Radiation</subject><subject>Spinal cord</subject><subject>Surgery</subject><subject>Tumors</subject><issn>0022-3069</issn><issn>1554-6578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90EFLwzAUwPEgCs7pzQ8Q8KCH1b0mTdscpeoUJgrOc3lNU5eRNTVpD357O-rJg6fHgx-Px5-QyxhuY5B8uWt1u2wtKsjEEZnFQiRRKrL8mMwAGIs4pPKUnIWwAwAJMpmRTWFNaxTaBX3Dfuus-5w2bGv64qxWg0VPiy16VL32JvRGBeoaem-aZgiavnemRUsL52u6ssbtMZyTkwZt0Be_c04-Hh82xVO0fl09F3frSHHG-whrhhKySirFNUOe6xrStOKcp7LKsNE8jROopBAiTjJV8Vw2Sqg6k6oSCIzPyc10t_Pua9ChL_cmKG0tttoNoWQZiEwwxvORXv2hOzf48fFR5SMQgolkVItJKe9C8LopO2_26L_LGMpD4vKQuPxNPPLribuh-1_-ADMVfSQ</recordid><startdate>20221018</startdate><enddate>20221018</enddate><creator>Garcia, Mekka R</creator><creator>Feng, Yang</creator><creator>Vasudevaraja, Varshini</creator><creator>Galbraith, Kristyn</creator><creator>Serrano, Jonathan</creator><creator>Thomas, Cheddhi</creator><creator>Radmanesh, Alireza</creator><creator>Hidalgo, Eveline T</creator><creator>Harter, David H</creator><creator>Allen, Jeffrey C</creator><creator>Gardner, Sharon L</creator><creator>Osorio, Diana S</creator><creator>William, Christopher M</creator><creator>Zagzag, David</creator><creator>Boué, Daniel R</creator><creator>Snuderl, Matija</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0752-0917</orcidid></search><sort><creationdate>20221018</creationdate><title>Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas</title><author>Garcia, Mekka R ; 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Diffuse spinal cord gliomas (SCGs) are rare tumors associated with a high morbidity and mortality that affect both pediatric and adult populations. In this retrospective study, we sought to characterize the clinical, pathological, and molecular features of diffuse SCG in 22 patients with histological and molecular analyses. The median age of our cohort was 23.64 years (range 1–82) and the overall median survival was 397 days. K27M mutation was significantly more prevalent in males compared to females. Gross total resection and chemotherapy were associated with improved survival, compared to biopsy and no chemotherapy. While there was no association between tumor grade, K27M status (p = 0.366) or radiation (p = 0.772), and survival, males showed a trend toward shorter survival. K27M mutant tumors showed increased chromosomal instability and a distinct DNA methylation signature.</abstract><cop>Cary</cop><pub>Oxford University Press</pub><doi>10.1093/jnen/nlac075</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0752-0917</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Biopsy Brain cancer Chemotherapy DNA methylation Genetic testing Genomes Glioma Histology Hospitals Laboratories Medical prognosis Mutation Pathology Pediatrics Radiation Spinal cord Surgery Tumors |
| title | Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas |
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