In vitro and in vivo local tolerability of a synergistic anti‐tuberculosis drug combination intended for pulmonary delivery

A drug combination, vancomycin (VAN) plus tetrahydrolipstatin (THL), has demonstrated an effective synergistic action in vitro against Mycobacterium tuberculosis (Mtb). The poor oral bioavailability of VAN and THL and the predominant tropism of Mtb infection to the lungs make their pulmonary adminis...

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Veröffentlicht in:	Journal of applied toxicology 2023-02, Vol.43 (2), p.298-311
Hauptverfasser:	Ravon, Faustine, Menchi, Elena, Lambot, Coralie, Al Kattar, Sahar, Chraibi, Selma, Remmelink, Myriam, Fontaine, Véronique, Wauthoz, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar Epithelial Cells Alveoli Animals Antibiotics Antitubercular Agents - toxicity Bioavailability Biocompatibility Biomarkers Bronchoalveolar Lavage Fluid Bronchus Cell lines Cytotoxicity Damage Epithelium Histopathology Humans Inflammation Interleukin 6 Lavage Lung Lungs Mice Minimum inhibitory concentration Monocytes Mycobacterium tuberculosis Orlistat - pharmacology pulmonary delivery pulmonary tolerance tetrahydrolipstatin Toxicity Tropism Tuberculosis Tumor necrosis factor Vancomycin Weight loss
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