Gray matter atrophy and corresponding impairments in connectivity in patients with anti-N-methyl-D-aspartate receptor encephalitis
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disease that is commonly accompanied by cognitive impairment and various neurological and psychiatric symptoms, advanced image analyses help explore the pathogenesis of this disease. Therefore, this study aimed to explore...
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| Veröffentlicht in: | Brain imaging and behavior 2022-10, Vol.16 (5), p.2001-2010 |
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| creator | Guo, Yuanyuan Lv, Xinyi Zhang, Juanjuan Li, Chenglong Wei, Ling Zhou, Nong Xu, Jinping Tian, Yanghua Wang, Kai |
| description | Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disease that is commonly accompanied by cognitive impairment and various neurological and psychiatric symptoms, advanced image analyses help explore the pathogenesis of this disease. Therefore, this study aimed to explore specific structural and functional alterations and their relationship with the clinical symptoms of anti-NMDAR encephalitis. In this study, twenty-two patients with anti-NMDAR encephalitis after the acute stage and 29 controls received cognitive assessments and magnetic resonance imaging. Grey matter atrophy was measured using voxel-based morphometry, and functional alterations in abnormal regions were subsequently investigated using resting state functional connectivity (RSFC). Finally, correlation analyses were performed to explore the associations between imaging alterations and cognitive assessments. The patients demonstrated significant gray matter atrophy in the bilateral triangle part of the inferior frontal gyrus (triIFG.L and triIFG.R) and right precuneus, decreased RSFC between triIFG.L and bilateral Heschl gyrus (HES), decreased RSFC between triIFG.R and HES.R, decreased RSFC between right precuneus and left cerebellum, and increased RSFC between triIFG.R and left superior frontal gyrus. Further correlation analyses showed that the gray matter volume in triIFG.R and decreased RSFC between triIFG.L and HES.R were associated with decreased memory scores, whereas decreased RSFC between triIFG.R and HES.R was marginally correlated with the disease course in patients. In conclusion, this study suggests that cognitive impairments in patients with anti-NMDAR encephalitis may be mainly associated with gray matter atrophy and abnormal RSFC in the triIFG. These findings provide new insights into anti-NMDAR encephalitis pathogenesis and help explore potential treatments. |
| doi_str_mv | 10.1007/s11682-022-00670-5 |
| format | Article |
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Therefore, this study aimed to explore specific structural and functional alterations and their relationship with the clinical symptoms of anti-NMDAR encephalitis. In this study, twenty-two patients with anti-NMDAR encephalitis after the acute stage and 29 controls received cognitive assessments and magnetic resonance imaging. Grey matter atrophy was measured using voxel-based morphometry, and functional alterations in abnormal regions were subsequently investigated using resting state functional connectivity (RSFC). Finally, correlation analyses were performed to explore the associations between imaging alterations and cognitive assessments. The patients demonstrated significant gray matter atrophy in the bilateral triangle part of the inferior frontal gyrus (triIFG.L and triIFG.R) and right precuneus, decreased RSFC between triIFG.L and bilateral Heschl gyrus (HES), decreased RSFC between triIFG.R and HES.R, decreased RSFC between right precuneus and left cerebellum, and increased RSFC between triIFG.R and left superior frontal gyrus. Further correlation analyses showed that the gray matter volume in triIFG.R and decreased RSFC between triIFG.L and HES.R were associated with decreased memory scores, whereas decreased RSFC between triIFG.R and HES.R was marginally correlated with the disease course in patients. In conclusion, this study suggests that cognitive impairments in patients with anti-NMDAR encephalitis may be mainly associated with gray matter atrophy and abnormal RSFC in the triIFG. These findings provide new insights into anti-NMDAR encephalitis pathogenesis and help explore potential treatments.</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-022-00670-5</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Assessments ; Atrophy ; Autoimmune diseases ; Biomedical and Life Sciences ; Biomedicine ; Cerebellum ; Cognitive ability ; Cortex (parietal) ; Encephalitis ; Frontal gyrus ; Glutamic acid receptors ; Magnetic resonance imaging ; Medical imaging ; Morphometry ; N-Methyl-D-aspartic acid receptors ; Neural networks ; Neurological complications ; Neuropsychology ; Neuroradiology ; Neurosciences ; Original Research ; Pathogenesis ; Patients ; Psychiatry ; Receptors ; Signs and symptoms ; Structure-function relationships ; Substantia grisea</subject><ispartof>Brain imaging and behavior, 2022-10, Vol.16 (5), p.2001-2010</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-ad1b4836e3a2ea1d3ec385a82404399a55e49c72ac2be1ce001e130d37bb28d43</citedby><cites>FETCH-LOGICAL-c396t-ad1b4836e3a2ea1d3ec385a82404399a55e49c72ac2be1ce001e130d37bb28d43</cites><orcidid>0000-0002-1295-7411</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11682-022-00670-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11682-022-00670-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Guo, Yuanyuan</creatorcontrib><creatorcontrib>Lv, Xinyi</creatorcontrib><creatorcontrib>Zhang, Juanjuan</creatorcontrib><creatorcontrib>Li, Chenglong</creatorcontrib><creatorcontrib>Wei, Ling</creatorcontrib><creatorcontrib>Zhou, Nong</creatorcontrib><creatorcontrib>Xu, Jinping</creatorcontrib><creatorcontrib>Tian, Yanghua</creatorcontrib><creatorcontrib>Wang, Kai</creatorcontrib><title>Gray matter atrophy and corresponding impairments in connectivity in patients with anti-N-methyl-D-aspartate receptor encephalitis</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><description>Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disease that is commonly accompanied by cognitive impairment and various neurological and psychiatric symptoms, advanced image analyses help explore the pathogenesis of this disease. Therefore, this study aimed to explore specific structural and functional alterations and their relationship with the clinical symptoms of anti-NMDAR encephalitis. In this study, twenty-two patients with anti-NMDAR encephalitis after the acute stage and 29 controls received cognitive assessments and magnetic resonance imaging. Grey matter atrophy was measured using voxel-based morphometry, and functional alterations in abnormal regions were subsequently investigated using resting state functional connectivity (RSFC). Finally, correlation analyses were performed to explore the associations between imaging alterations and cognitive assessments. The patients demonstrated significant gray matter atrophy in the bilateral triangle part of the inferior frontal gyrus (triIFG.L and triIFG.R) and right precuneus, decreased RSFC between triIFG.L and bilateral Heschl gyrus (HES), decreased RSFC between triIFG.R and HES.R, decreased RSFC between right precuneus and left cerebellum, and increased RSFC between triIFG.R and left superior frontal gyrus. Further correlation analyses showed that the gray matter volume in triIFG.R and decreased RSFC between triIFG.L and HES.R were associated with decreased memory scores, whereas decreased RSFC between triIFG.R and HES.R was marginally correlated with the disease course in patients. In conclusion, this study suggests that cognitive impairments in patients with anti-NMDAR encephalitis may be mainly associated with gray matter atrophy and abnormal RSFC in the triIFG. 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matter atrophy and corresponding impairments in connectivity in patients with anti-N-methyl-D-aspartate receptor encephalitis</title><author>Guo, Yuanyuan ; Lv, Xinyi ; Zhang, Juanjuan ; Li, Chenglong ; Wei, Ling ; Zhou, Nong ; Xu, Jinping ; Tian, Yanghua ; Wang, Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-ad1b4836e3a2ea1d3ec385a82404399a55e49c72ac2be1ce001e130d37bb28d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Assessments</topic><topic>Atrophy</topic><topic>Autoimmune diseases</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cerebellum</topic><topic>Cognitive ability</topic><topic>Cortex (parietal)</topic><topic>Encephalitis</topic><topic>Frontal gyrus</topic><topic>Glutamic acid receptors</topic><topic>Magnetic resonance imaging</topic><topic>Medical 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Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gray matter atrophy and corresponding impairments in connectivity in patients with anti-N-methyl-D-aspartate receptor encephalitis</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><date>2022-10-01</date><risdate>2022</risdate><volume>16</volume><issue>5</issue><spage>2001</spage><epage>2010</epage><pages>2001-2010</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><abstract>Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disease that is commonly accompanied by cognitive impairment and various neurological and psychiatric symptoms, advanced image analyses help explore the pathogenesis of this disease. Therefore, this study aimed to explore specific structural and functional alterations and their relationship with the clinical symptoms of anti-NMDAR encephalitis. In this study, twenty-two patients with anti-NMDAR encephalitis after the acute stage and 29 controls received cognitive assessments and magnetic resonance imaging. Grey matter atrophy was measured using voxel-based morphometry, and functional alterations in abnormal regions were subsequently investigated using resting state functional connectivity (RSFC). Finally, correlation analyses were performed to explore the associations between imaging alterations and cognitive assessments. The patients demonstrated significant gray matter atrophy in the bilateral triangle part of the inferior frontal gyrus (triIFG.L and triIFG.R) and right precuneus, decreased RSFC between triIFG.L and bilateral Heschl gyrus (HES), decreased RSFC between triIFG.R and HES.R, decreased RSFC between right precuneus and left cerebellum, and increased RSFC between triIFG.R and left superior frontal gyrus. Further correlation analyses showed that the gray matter volume in triIFG.R and decreased RSFC between triIFG.L and HES.R were associated with decreased memory scores, whereas decreased RSFC between triIFG.R and HES.R was marginally correlated with the disease course in patients. In conclusion, this study suggests that cognitive impairments in patients with anti-NMDAR encephalitis may be mainly associated with gray matter atrophy and abnormal RSFC in the triIFG. These findings provide new insights into anti-NMDAR encephalitis pathogenesis and help explore potential treatments.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11682-022-00670-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1295-7411</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Assessments Atrophy Autoimmune diseases Biomedical and Life Sciences Biomedicine Cerebellum Cognitive ability Cortex (parietal) Encephalitis Frontal gyrus Glutamic acid receptors Magnetic resonance imaging Medical imaging Morphometry N-Methyl-D-aspartic acid receptors Neural networks Neurological complications Neuropsychology Neuroradiology Neurosciences Original Research Pathogenesis Patients Psychiatry Receptors Signs and symptoms Structure-function relationships Substantia grisea |
| title | Gray matter atrophy and corresponding impairments in connectivity in patients with anti-N-methyl-D-aspartate receptor encephalitis |
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