In‐hospital incidence of and risk factors for influenza‐associated respiratory failure
Background Respiratory failure (RF) is the most important complication of influenza virus infection. Its definition and incidence are heterogeneous in the literature. Methods This systematic review and meta‐analysis aim to determine the incidence of and risk factors for RF in patients hospitalized w...
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| Veröffentlicht in: | European journal of clinical investigation 2022-11, Vol.52 (11), p.e13858-n/a |
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| creator | Ayuso García, Blanca Marchan, Alvaro Arrieta Ortubay, Estíbaliz Castillo Maza, Cristina Romay Lema, Eva Lalueza, Antonio Lumbreras, Carlos |
| description | Background
Respiratory failure (RF) is the most important complication of influenza virus infection. Its definition and incidence are heterogeneous in the literature.
Methods
This systematic review and meta‐analysis aim to determine the incidence of and risk factors for RF in patients hospitalized with influenza. Electronic databases were searched for articles on RF in patients hospitalized for influenza infection up to December 2021 regardless of their geographical location. Observational and experimental studies were considered for inclusion, excluding case series. The Newcastle‐Ottawa and Johanna Briggs scales were used for quality assessment. A random‐effects meta‐analysis was performed, followed by subgroup analyses according to, among others, presence/absence of pneumonia, RF definition, serotype and time period. PRISMA guidelines were followed for this review.
Results
Thirty‐six studies were finally included in the meta‐analysis. Overall, RF incidence was 24% (range 5%–85%, 95% confidence interval [95CI] 19%–31%). Significantly higher incidences of RF were found in patients with pneumonia (42%, 95CI 28%–57%, p = .006), when RF was defined as hypoxemia (58%, 95CI 31%–81%, p |
| doi_str_mv | 10.1111/eci.13858 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2705750473</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2705750473</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2908-46856c03422c386fdf5421c5f09d06e4ea1cf798df2051053f2bae961eb2784c3</originalsourceid><addsrcrecordid>eNp10L9OwzAQBnALgUQpDLxBJBYYUvw_zoiqApUqscDCYrnOWbikcbEToTLxCDwjT4KhTEjccsvvO50-hE4JnpA8l2D9hDAl1B4aESZFSZmk-2iEMeElrSt6iI5SWmGMFWF0hB7n3ef7x1NIG9-btvCd9Q10ForgCtM1RfTpuXDG9iGmwoWYhWsH6N5MjpmUgvWmh-wgX4gms23mvh0iHKMDZ9oEJ797jB6uZ_fT23JxdzOfXi1KS2usSi6VkBYzTqllSrrGCU6JFQ7XDZbAwRDrqlo1jmJBsGCOLg3UksCSVopbNkbnu7ubGF4GSL1e-2ShbU0HYUiaVlhUAvOKZXr2h67CELv8XVaU40qqzMboYqdsDClFcHoT_drErSZYf7esc8v6p-VsL3f21bew_R_q2XS-S3wBnVB_5Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2724076847</pqid></control><display><type>article</type><title>In‐hospital incidence of and risk factors for influenza‐associated respiratory failure</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ayuso García, Blanca ; Marchan, Alvaro ; Arrieta Ortubay, Estíbaliz ; Castillo Maza, Cristina ; Romay Lema, Eva ; Lalueza, Antonio ; Lumbreras, Carlos</creator><creatorcontrib>Ayuso García, Blanca ; Marchan, Alvaro ; Arrieta Ortubay, Estíbaliz ; Castillo Maza, Cristina ; Romay Lema, Eva ; Lalueza, Antonio ; Lumbreras, Carlos</creatorcontrib><description>Background
Respiratory failure (RF) is the most important complication of influenza virus infection. Its definition and incidence are heterogeneous in the literature.
Methods
This systematic review and meta‐analysis aim to determine the incidence of and risk factors for RF in patients hospitalized with influenza. Electronic databases were searched for articles on RF in patients hospitalized for influenza infection up to December 2021 regardless of their geographical location. Observational and experimental studies were considered for inclusion, excluding case series. The Newcastle‐Ottawa and Johanna Briggs scales were used for quality assessment. A random‐effects meta‐analysis was performed, followed by subgroup analyses according to, among others, presence/absence of pneumonia, RF definition, serotype and time period. PRISMA guidelines were followed for this review.
Results
Thirty‐six studies were finally included in the meta‐analysis. Overall, RF incidence was 24% (range 5%–85%, 95% confidence interval [95CI] 19%–31%). Significantly higher incidences of RF were found in patients with pneumonia (42%, 95CI 28%–57%, p = .006), when RF was defined as hypoxemia (58%, 95CI 31%–81%, p < .001), and during the 2009 pandemic (25%, 95CI 16%–36%) and postpandemic period (23%, 95CI 15%–34%, p = .01). No differences were found between human influenza serotypes. Assessment of risk factors associated with the development of RF was not possible due to their inconsistent and heterogeneous reporting.
Conclusion
Respiratory failure is frequent in hospitalized influenza patients, especially in patients with pneumonia and since the 2009 pandemic, although its definition and reporting widely vary in the literature. This complicates its characterization and comparison between cohorts and with other respiratory viruses.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/eci.13858</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Failure ; Geographical distribution ; Geographical locations ; Hospitalization ; human influenza ; Hypoxemia ; Infections ; Influenza ; Literature reviews ; mechanical ventilation ; Meta-analysis ; Pandemics ; Patients ; Pneumonia ; Quality assessment ; Quality control ; Respiratory failure ; Risk analysis ; Risk assessment ; Risk factors ; Serotypes ; Subgroups ; viral pneumonia ; Viruses</subject><ispartof>European journal of clinical investigation, 2022-11, Vol.52 (11), p.e13858-n/a</ispartof><rights>2022 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd</rights><rights>Copyright © 2022 Stichting European Society for Clinical Investigation Journal Foundation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2908-46856c03422c386fdf5421c5f09d06e4ea1cf798df2051053f2bae961eb2784c3</cites><orcidid>0000-0001-5949-8032</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Feci.13858$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Feci.13858$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Ayuso García, Blanca</creatorcontrib><creatorcontrib>Marchan, Alvaro</creatorcontrib><creatorcontrib>Arrieta Ortubay, Estíbaliz</creatorcontrib><creatorcontrib>Castillo Maza, Cristina</creatorcontrib><creatorcontrib>Romay Lema, Eva</creatorcontrib><creatorcontrib>Lalueza, Antonio</creatorcontrib><creatorcontrib>Lumbreras, Carlos</creatorcontrib><title>In‐hospital incidence of and risk factors for influenza‐associated respiratory failure</title><title>European journal of clinical investigation</title><description>Background
Respiratory failure (RF) is the most important complication of influenza virus infection. Its definition and incidence are heterogeneous in the literature.
Methods
This systematic review and meta‐analysis aim to determine the incidence of and risk factors for RF in patients hospitalized with influenza. Electronic databases were searched for articles on RF in patients hospitalized for influenza infection up to December 2021 regardless of their geographical location. Observational and experimental studies were considered for inclusion, excluding case series. The Newcastle‐Ottawa and Johanna Briggs scales were used for quality assessment. A random‐effects meta‐analysis was performed, followed by subgroup analyses according to, among others, presence/absence of pneumonia, RF definition, serotype and time period. PRISMA guidelines were followed for this review.
Results
Thirty‐six studies were finally included in the meta‐analysis. Overall, RF incidence was 24% (range 5%–85%, 95% confidence interval [95CI] 19%–31%). Significantly higher incidences of RF were found in patients with pneumonia (42%, 95CI 28%–57%, p = .006), when RF was defined as hypoxemia (58%, 95CI 31%–81%, p < .001), and during the 2009 pandemic (25%, 95CI 16%–36%) and postpandemic period (23%, 95CI 15%–34%, p = .01). No differences were found between human influenza serotypes. Assessment of risk factors associated with the development of RF was not possible due to their inconsistent and heterogeneous reporting.
Conclusion
Respiratory failure is frequent in hospitalized influenza patients, especially in patients with pneumonia and since the 2009 pandemic, although its definition and reporting widely vary in the literature. This complicates its characterization and comparison between cohorts and with other respiratory viruses.</description><subject>Failure</subject><subject>Geographical distribution</subject><subject>Geographical locations</subject><subject>Hospitalization</subject><subject>human influenza</subject><subject>Hypoxemia</subject><subject>Infections</subject><subject>Influenza</subject><subject>Literature reviews</subject><subject>mechanical ventilation</subject><subject>Meta-analysis</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Quality assessment</subject><subject>Quality control</subject><subject>Respiratory failure</subject><subject>Risk analysis</subject><subject>Risk assessment</subject><subject>Risk factors</subject><subject>Serotypes</subject><subject>Subgroups</subject><subject>viral pneumonia</subject><subject>Viruses</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp10L9OwzAQBnALgUQpDLxBJBYYUvw_zoiqApUqscDCYrnOWbikcbEToTLxCDwjT4KhTEjccsvvO50-hE4JnpA8l2D9hDAl1B4aESZFSZmk-2iEMeElrSt6iI5SWmGMFWF0hB7n3ef7x1NIG9-btvCd9Q10ForgCtM1RfTpuXDG9iGmwoWYhWsH6N5MjpmUgvWmh-wgX4gms23mvh0iHKMDZ9oEJ797jB6uZ_fT23JxdzOfXi1KS2usSi6VkBYzTqllSrrGCU6JFQ7XDZbAwRDrqlo1jmJBsGCOLg3UksCSVopbNkbnu7ubGF4GSL1e-2ShbU0HYUiaVlhUAvOKZXr2h67CELv8XVaU40qqzMboYqdsDClFcHoT_drErSZYf7esc8v6p-VsL3f21bew_R_q2XS-S3wBnVB_5Q</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Ayuso García, Blanca</creator><creator>Marchan, Alvaro</creator><creator>Arrieta Ortubay, Estíbaliz</creator><creator>Castillo Maza, Cristina</creator><creator>Romay Lema, Eva</creator><creator>Lalueza, Antonio</creator><creator>Lumbreras, Carlos</creator><general>Blackwell Publishing Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5949-8032</orcidid></search><sort><creationdate>202211</creationdate><title>In‐hospital incidence of and risk factors for influenza‐associated respiratory failure</title><author>Ayuso García, Blanca ; Marchan, Alvaro ; Arrieta Ortubay, Estíbaliz ; Castillo Maza, Cristina ; Romay Lema, Eva ; Lalueza, Antonio ; Lumbreras, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2908-46856c03422c386fdf5421c5f09d06e4ea1cf798df2051053f2bae961eb2784c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Failure</topic><topic>Geographical distribution</topic><topic>Geographical locations</topic><topic>Hospitalization</topic><topic>human influenza</topic><topic>Hypoxemia</topic><topic>Infections</topic><topic>Influenza</topic><topic>Literature reviews</topic><topic>mechanical ventilation</topic><topic>Meta-analysis</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Quality assessment</topic><topic>Quality control</topic><topic>Respiratory failure</topic><topic>Risk analysis</topic><topic>Risk assessment</topic><topic>Risk factors</topic><topic>Serotypes</topic><topic>Subgroups</topic><topic>viral pneumonia</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayuso García, Blanca</creatorcontrib><creatorcontrib>Marchan, Alvaro</creatorcontrib><creatorcontrib>Arrieta Ortubay, Estíbaliz</creatorcontrib><creatorcontrib>Castillo Maza, Cristina</creatorcontrib><creatorcontrib>Romay Lema, Eva</creatorcontrib><creatorcontrib>Lalueza, Antonio</creatorcontrib><creatorcontrib>Lumbreras, Carlos</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayuso García, Blanca</au><au>Marchan, Alvaro</au><au>Arrieta Ortubay, Estíbaliz</au><au>Castillo Maza, Cristina</au><au>Romay Lema, Eva</au><au>Lalueza, Antonio</au><au>Lumbreras, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In‐hospital incidence of and risk factors for influenza‐associated respiratory failure</atitle><jtitle>European journal of clinical investigation</jtitle><date>2022-11</date><risdate>2022</risdate><volume>52</volume><issue>11</issue><spage>e13858</spage><epage>n/a</epage><pages>e13858-n/a</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background
Respiratory failure (RF) is the most important complication of influenza virus infection. Its definition and incidence are heterogeneous in the literature.
Methods
This systematic review and meta‐analysis aim to determine the incidence of and risk factors for RF in patients hospitalized with influenza. Electronic databases were searched for articles on RF in patients hospitalized for influenza infection up to December 2021 regardless of their geographical location. Observational and experimental studies were considered for inclusion, excluding case series. The Newcastle‐Ottawa and Johanna Briggs scales were used for quality assessment. A random‐effects meta‐analysis was performed, followed by subgroup analyses according to, among others, presence/absence of pneumonia, RF definition, serotype and time period. PRISMA guidelines were followed for this review.
Results
Thirty‐six studies were finally included in the meta‐analysis. Overall, RF incidence was 24% (range 5%–85%, 95% confidence interval [95CI] 19%–31%). Significantly higher incidences of RF were found in patients with pneumonia (42%, 95CI 28%–57%, p = .006), when RF was defined as hypoxemia (58%, 95CI 31%–81%, p < .001), and during the 2009 pandemic (25%, 95CI 16%–36%) and postpandemic period (23%, 95CI 15%–34%, p = .01). No differences were found between human influenza serotypes. Assessment of risk factors associated with the development of RF was not possible due to their inconsistent and heterogeneous reporting.
Conclusion
Respiratory failure is frequent in hospitalized influenza patients, especially in patients with pneumonia and since the 2009 pandemic, although its definition and reporting widely vary in the literature. This complicates its characterization and comparison between cohorts and with other respiratory viruses.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1111/eci.13858</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5949-8032</orcidid></addata></record> |
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| subjects | Failure Geographical distribution Geographical locations Hospitalization human influenza Hypoxemia Infections Influenza Literature reviews mechanical ventilation Meta-analysis Pandemics Patients Pneumonia Quality assessment Quality control Respiratory failure Risk analysis Risk assessment Risk factors Serotypes Subgroups viral pneumonia Viruses |
| title | In‐hospital incidence of and risk factors for influenza‐associated respiratory failure |
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