A simple and sensitive LC-MS/MS method for determination of doxylamine in human plasma and its application in a bioequivalence study in healthy Chinese volunteers

A simple, rapid, sensitive and specific LC-MS/MS method was developed and validated for the quantitative determination of doxylamine in human plasma, using isotope doxylamine-d5 as internal standard (IS). The detection was conducted on a QTRAP 5500 tandem mass spectrometer coupled with electrospray...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2022-10, Vol.220, p.114984-114984, Article 114984
Hauptverfasser:	Fu, Rong, Sheng, Mang, Yang, Can, Liu, Luyao, Xiong, Wenqiang, Wang, Xing, Chen, Xiaodan, Yu, Zhongjian, Gao, Yuan, Tan, Hong, Xin, Chenlu, Zhang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioequivalence study Doxylamine Human plasma LC-MS/MS Protein precipitation method
Online-Zugang:	Volltext
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