AIE-active iridium() complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

The integration of an aggregation induced emission (AIE)-active Ir( iii ) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N . This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high 1 O 2 generation ability, thereby effectively killing 4T1 mouse cancer cells in vitro . This work has potential for future photodynamic therapy (PDT) applications. The integration of an aggregation induced emission (AIE)-active Ir( iii ) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N , for photodynamic therapy (PDT) applications.