Activation of Adaptive and Innate Immune Cells via Localized IL2 Cytokine Factories Eradicates Mesothelioma Tumors

IL2 immunotherapy has the potential to elicit immune-mediated tumor lysis via activation of effector immune cells, but clinical utility is limited due to pharmacokinetic challenges as well as vascular leak syndrome and other life-threatening toxicities experienced by patients. We developed a safe an...

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Veröffentlicht in:	Clinical cancer research 2022-12, Vol.28 (23), p.5121-5135
Hauptverfasser:	Nash, Amanda M, Aghlara-Fotovat, Samira, Castillio, Bertha, Hernandez, Andrea, Pugazenthi, Aarthi, Lee, Hyun-Sung, Jang, Hee-Jin, Nguyen, Annie, Lu, Alexander, Burt, Bryan M, Ghanta, Ravi K, Veiseh, Omid
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7-H1 Antigen - immunology Cytokines Immunity, Innate Interleukin-2 - administration & dosage Mesothelioma - pathology Mesothelioma, Malignant Mice
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