Sulfated modification of hyaluronan tetrasaccharide enhances its antitumor activity on human lung adenocarcinoma A549 cells in vitro and in vivo

[Display omitted] •Chondroitinase ABC enzyme was induced from recombinant engineering bacterial E. coli BL21/pET-28a-csabc.•Hyaluronan tetrasaccharide (HA4) and its sulfated derivates with different sulfate contents were prepared and identified.•HA4 and its three sulfated derivatives showed differen...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2022-11, Vol.75, p.128945-128945, Article 128945
Hauptverfasser:	He, Xinyue, Wang, Sanying, Liu, Bing, Jiang, Di, Chen, Fen, Mao, Genxiang, Jin, Weihua, Pan, Hongying, Zhong, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor Apoptosis Hyaluronan Sulfation modification Tetrasaccharide
Online-Zugang:	Volltext
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