Functional neuroimaging in psychiatry and the case for failing better
Psychiatric disorders encompass complex aberrations of cognition and affect and are among the most debilitating and poorly understood of any medical condition. Current treatments rely primarily on interventions that target brain function (drugs) or learning processes (psychotherapy). A mechanistic u...
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Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2022-08, Vol.110 (16), p.2524-2544 |
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description | Psychiatric disorders encompass complex aberrations of cognition and affect and are among the most debilitating and poorly understood of any medical condition. Current treatments rely primarily on interventions that target brain function (drugs) or learning processes (psychotherapy). A mechanistic understanding of how these interventions mediate their therapeutic effects remains elusive. From the early 1990s, non-invasive functional neuroimaging, coupled with parallel developments in the cognitive neurosciences, seemed to signal a new era of neurobiologically grounded diagnosis and treatment in psychiatry. Yet, despite three decades of intense neuroimaging research, we still lack a neurobiological account for any psychiatric condition. Likewise, functional neuroimaging plays no role in clinical decision making. Here, we offer a critical commentary on this impasse and suggest how the field might fare better and deliver impactful neurobiological insights.
The confluence of functional neuroimaging and cognitive neuroscience has revolutionized psychiatric research, yet clinical translation has been lacking. Nour et al. provide a critical perspective on this impasse and suggest how the field might fare better in the future. |
doi_str_mv | 10.1016/j.neuron.2022.07.005 |
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The confluence of functional neuroimaging and cognitive neuroscience has revolutionized psychiatric research, yet clinical translation has been lacking. Nour et al. provide a critical perspective on this impasse and suggest how the field might fare better in the future.</description><subject>cognitive neuroscience</subject><subject>computational psychiatry</subject><subject>EEG</subject><subject>electroencephalography</subject><subject>fMRI</subject><subject>functional magnetic resonance imaging</subject><subject>magnetoencephalography</subject><subject>MEG</subject><subject>precision psychiatry</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kLFOwzAURS0EEqXwBwweWRKeHSeOFyRUtYBUiaW75TovravUKbaD1L8nJcxMd7n3SPcQ8sggZ8Cq50PucQi9zzlwnoPMAcorMmOgZCaYUtdkBrWqsorL4pbcxXgAYKJUbEaWq8Hb5HpvOvoLcUezc35HnaeneLZ7Z1I4U-MbmvZIrYlI2z7Q1rjuUttiShjuyU1ruogPfzknm9Vys3jP1p9vH4vXdWZFyVKmjAAFrG2LEtpCYNUYkNjIWiBvS6yN4AyZqLdCMmkqw5pKITcoC6hrZoo5eZqwp9B_DRiTPrposeuMx36ImksQtYSiYGNVTFUb-hgDtvoUxmvhrBnoizR90JM0fZGmQepR2jh7mWY4vvh2GHS0Dr3FxgW0STe9-x_wA3fLd3U</recordid><startdate>20220817</startdate><enddate>20220817</enddate><creator>Nour, Matthew M.</creator><creator>Liu, Yunzhe</creator><creator>Dolan, Raymond J.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220817</creationdate><title>Functional neuroimaging in psychiatry and the case for failing better</title><author>Nour, Matthew M. ; Liu, Yunzhe ; Dolan, Raymond J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-9a40901ff350f34e6da07ed784e2f5e8a421e148b4717a6a1d69e2ae730881a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>cognitive neuroscience</topic><topic>computational psychiatry</topic><topic>EEG</topic><topic>electroencephalography</topic><topic>fMRI</topic><topic>functional magnetic resonance imaging</topic><topic>magnetoencephalography</topic><topic>MEG</topic><topic>precision psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nour, Matthew M.</creatorcontrib><creatorcontrib>Liu, Yunzhe</creatorcontrib><creatorcontrib>Dolan, Raymond J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nour, Matthew M.</au><au>Liu, Yunzhe</au><au>Dolan, Raymond J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional neuroimaging in psychiatry and the case for failing better</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><date>2022-08-17</date><risdate>2022</risdate><volume>110</volume><issue>16</issue><spage>2524</spage><epage>2544</epage><pages>2524-2544</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>Psychiatric disorders encompass complex aberrations of cognition and affect and are among the most debilitating and poorly understood of any medical condition. Current treatments rely primarily on interventions that target brain function (drugs) or learning processes (psychotherapy). A mechanistic understanding of how these interventions mediate their therapeutic effects remains elusive. From the early 1990s, non-invasive functional neuroimaging, coupled with parallel developments in the cognitive neurosciences, seemed to signal a new era of neurobiologically grounded diagnosis and treatment in psychiatry. Yet, despite three decades of intense neuroimaging research, we still lack a neurobiological account for any psychiatric condition. Likewise, functional neuroimaging plays no role in clinical decision making. Here, we offer a critical commentary on this impasse and suggest how the field might fare better and deliver impactful neurobiological insights.
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subjects | cognitive neuroscience computational psychiatry EEG electroencephalography fMRI functional magnetic resonance imaging magnetoencephalography MEG precision psychiatry |
title | Functional neuroimaging in psychiatry and the case for failing better |
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