De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function

Signaling by single-pass transmembrane receptors often involves a formation of ligand-induced receptor dimers with particular conformation, and bivalent receptor binders can modulate receptor functions by inducing different receptor dimer conformations, although such agents are difficult to design....

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Veröffentlicht in:	Structure (London) 2022-10, Vol.30 (10), p.1411-1423.e4
Hauptverfasser:	Sugano-Nakamura, Nozomi, Matoba, Kyoko, Hirose, Mika, Bashiruddin, Nasir K., Matsunaga, Yukiko, Yamashita, Keitaro, Hirata, Kunio, Yamamoto, Masaki, Arimori, Takao, Suga, Hiroaki, Takagi, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody surrogate cyclic peptide negative stain EM plexin receptor agonist receptor antagonist receptor dimerization semaphorin signal transduction
Online-Zugang:	Volltext
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