Variation in the Transcriptome Response and Detoxification Gene Diversity Drives Pesticide Tolerance in Fishes
Pesticides are critical for invasive species management but often have negative effects on nontarget native biota. Tolerance to pesticides should have an evolutionary basis, but this is poorly understood. Invasive sea lamprey (Petromyzon marinus) populations in North America have been controlled wit...
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| Veröffentlicht in: | Environmental science & technology 2022-09, Vol.56 (17), p.12137-12147 |
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| creator | Lawrence, M. J. Grayson, P. Jeffrey, J. D. Docker, M. F. Garroway, C. J. Wilson, J. M. Manzon, R. G. Wilkie, M. P. Jeffries, K. M. |
| description | Pesticides are critical for invasive species management but often have negative effects on nontarget native biota. Tolerance to pesticides should have an evolutionary basis, but this is poorly understood. Invasive sea lamprey (Petromyzon marinus) populations in North America have been controlled with a pesticide lethal to them at lower concentrations than native fishes. We addressed how interspecific variation in gene expression and detoxification gene diversity confer differential pesticide sensitivity in two fish species. We exposed sea lamprey and bluegill (Lepomis macrochirus), a tolerant native species, to 3-trifluoromethyl-4-nitrophenol (TFM), a pesticide commonly used in sea lamprey control. We then used whole-transcriptome sequencing of gill and liver to characterize the cellular response in both species. Comparatively, bluegill exhibited a larger number of detoxification genes expressed and a larger number of responsive transcripts overall, which likely contributes to greater tolerance to TFM. Understanding the genetic and physiological basis for pesticide tolerance is crucial for managing invasive species. |
| doi_str_mv | 10.1021/acs.est.2c00821 |
| format | Article |
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J. ; Grayson, P. ; Jeffrey, J. D. ; Docker, M. F. ; Garroway, C. J. ; Wilson, J. M. ; Manzon, R. G. ; Wilkie, M. P. ; Jeffries, K. M.</creator><creatorcontrib>Lawrence, M. J. ; Grayson, P. ; Jeffrey, J. D. ; Docker, M. F. ; Garroway, C. J. ; Wilson, J. M. ; Manzon, R. G. ; Wilkie, M. P. ; Jeffries, K. M.</creatorcontrib><description>Pesticides are critical for invasive species management but often have negative effects on nontarget native biota. Tolerance to pesticides should have an evolutionary basis, but this is poorly understood. Invasive sea lamprey (Petromyzon marinus) populations in North America have been controlled with a pesticide lethal to them at lower concentrations than native fishes. We addressed how interspecific variation in gene expression and detoxification gene diversity confer differential pesticide sensitivity in two fish species. We exposed sea lamprey and bluegill (Lepomis macrochirus), a tolerant native species, to 3-trifluoromethyl-4-nitrophenol (TFM), a pesticide commonly used in sea lamprey control. We then used whole-transcriptome sequencing of gill and liver to characterize the cellular response in both species. Comparatively, bluegill exhibited a larger number of detoxification genes expressed and a larger number of responsive transcripts overall, which likely contributes to greater tolerance to TFM. 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We addressed how interspecific variation in gene expression and detoxification gene diversity confer differential pesticide sensitivity in two fish species. We exposed sea lamprey and bluegill (Lepomis macrochirus), a tolerant native species, to 3-trifluoromethyl-4-nitrophenol (TFM), a pesticide commonly used in sea lamprey control. We then used whole-transcriptome sequencing of gill and liver to characterize the cellular response in both species. Comparatively, bluegill exhibited a larger number of detoxification genes expressed and a larger number of responsive transcripts overall, which likely contributes to greater tolerance to TFM. Understanding the genetic and physiological basis for pesticide tolerance is crucial for managing invasive species.</description><subject>Biota</subject><subject>Contaminants in Aquatic and Terrestrial Environments</subject><subject>Detoxification</subject><subject>Gene expression</subject><subject>Hepatocytes</subject><subject>Indigenous species</subject><subject>Introduced species</subject><subject>Invasive species</subject><subject>Nitrophenol</subject><subject>Nonnative species</subject><subject>p-Nitrophenol</subject><subject>Pesticides</subject><subject>Petromyzon marinus</subject><subject>Transcriptomes</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEURYMoWKtrtwE3gkz7ksxHZimtrUJBkSruhpi-0JQ2qclU7L83Q8WF4CoPcu7hcgm5ZDBgwNlQ6TjA2A64BpCcHZEeKzhkhSzYMekBMJHVonw7JWcxrgCAC5A94l5VsKq13lHraLtEOg_KRR3stvUbpM8Yt95FpMot6Bhb_2WN1YfAFB3Ssf3EEG27p-OQzkifUgmr7SKZ_BqTTGOnnti4xHhOToxaR7z4efvkZXI3H91ns8fpw-h2likBdZthroFXRpsK4T2vZVkUUggozELwkkMNpkYja25EaRZSoCplleucAzclU2Ul-uT64N0G_7FLjZqNjRrXa-XQ72LDKxA5K-qk7ZOrP-jK74JL7RLFuJQVY5Co4YHSwccY0DTbYDcq7BsGTbd_k_ZvuvTP_ilxc0h0H7_K_-hvak2IoA</recordid><startdate>20220906</startdate><enddate>20220906</enddate><creator>Lawrence, M. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variation in the Transcriptome Response and Detoxification Gene Diversity Drives Pesticide Tolerance in Fishes</atitle><jtitle>Environmental science & technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>2022-09-06</date><risdate>2022</risdate><volume>56</volume><issue>17</issue><spage>12137</spage><epage>12147</epage><pages>12137-12147</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><abstract>Pesticides are critical for invasive species management but often have negative effects on nontarget native biota. Tolerance to pesticides should have an evolutionary basis, but this is poorly understood. Invasive sea lamprey (Petromyzon marinus) populations in North America have been controlled with a pesticide lethal to them at lower concentrations than native fishes. 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| subjects | Biota Contaminants in Aquatic and Terrestrial Environments Detoxification Gene expression Hepatocytes Indigenous species Introduced species Invasive species Nitrophenol Nonnative species p-Nitrophenol Pesticides Petromyzon marinus Transcriptomes |
| title | Variation in the Transcriptome Response and Detoxification Gene Diversity Drives Pesticide Tolerance in Fishes |
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