Calciphylaxis and Kidney Disease: A Review
Calciphylaxis is a life-threatening complication most often associated with chronic kidney disease that occurs as a result of the deposition of calcium in dermal and adipose microvasculature. However, this condition may also be seen in patients with acute kidney injury. The high morbidity and mortal...
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| Veröffentlicht in: | American journal of kidney diseases 2023-02, Vol.81 (2), p.232-239 |
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| container_title | American journal of kidney diseases |
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| creator | Gallo Marin, Benjamin Aghagoli, Ghazal Hu, Susie L. Massoud, Cathy M. Robinson-Bostom, Leslie |
| description | Calciphylaxis is a life-threatening complication most often associated with chronic kidney disease that occurs as a result of the deposition of calcium in dermal and adipose microvasculature. However, this condition may also be seen in patients with acute kidney injury. The high morbidity and mortality rates associated with calciphylaxis highlight the importance to correctly diagnose and treat this condition. However, calciphylaxis remains a diagnosis that may be clinically challenging to make. Here, we review the literature on uremic calciphylaxis with a focus on its pathophysiology, clinical presentation, advances in diagnostic tools, and treatment strategies. We also discuss the unique histopathological features of calciphylaxis and contrast it with those of other forms of general vessel calcification. This review emphasizes the need for multidisciplinary collaboration including nephrology, dermatology, and palliative care to ultimately provide the best possible care to patients with calciphylaxis. |
| doi_str_mv | 10.1053/j.ajkd.2022.06.011 |
| format | Article |
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However, this condition may also be seen in patients with acute kidney injury. The high morbidity and mortality rates associated with calciphylaxis highlight the importance to correctly diagnose and treat this condition. However, calciphylaxis remains a diagnosis that may be clinically challenging to make. Here, we review the literature on uremic calciphylaxis with a focus on its pathophysiology, clinical presentation, advances in diagnostic tools, and treatment strategies. We also discuss the unique histopathological features of calciphylaxis and contrast it with those of other forms of general vessel calcification. 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However, this condition may also be seen in patients with acute kidney injury. The high morbidity and mortality rates associated with calciphylaxis highlight the importance to correctly diagnose and treat this condition. However, calciphylaxis remains a diagnosis that may be clinically challenging to make. Here, we review the literature on uremic calciphylaxis with a focus on its pathophysiology, clinical presentation, advances in diagnostic tools, and treatment strategies. We also discuss the unique histopathological features of calciphylaxis and contrast it with those of other forms of general vessel calcification. This review emphasizes the need for multidisciplinary collaboration including nephrology, dermatology, and palliative care to ultimately provide the best possible care to patients with calciphylaxis.</description><subject>calcific uremic arteriolopathy</subject><subject>Calciphylaxis</subject><subject>Calciphylaxis - diagnosis</subject><subject>Calciphylaxis - etiology</subject><subject>Calciphylaxis - therapy</subject><subject>Calcium</subject><subject>calcium apatite</subject><subject>dermatologic lesion</subject><subject>dialysis</subject><subject>end-stage renal disease (ESRD)</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>microvascular calcification</subject><subject>Obesity - complications</subject><subject>pain management</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>review</subject><subject>sodium thiosulfate (STS)</subject><subject>Vascular Calcification - etiology</subject><subject>vasculopathy</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMobk6_gA_SRxFab5I2bcSXMf_iQBB9Dllyi6ldO5ttum9vyqaPPl24nHPuPT9CTikkFDJ-WSW6-rAJA8YSEAlQukeGNGM8FgUv9skQWM5iwQsxIEfeVwAguRCHZMAzmUPKYUguJro2bvG-qfW385FubPTkbIOb6MZ51B6vonH0gmuHX8fkoNS1x5PdHJG3u9vXyUM8fb5_nIynsUkBlrEuWJ6XmFoIT3BM0RhLbYkCLTUsk0zMwnHkzBSZlEJLlmoL2tCwklxmfETOt7mLrv1coV-qufMG61o32K68Yjkwmedp1kvZVmq61vsOS7Xo3Fx3G0VB9YxUpXpGqmekQKjAKJjOdvmr2Rztn-UXShBcbwUYWobmnfLGYWPQug7NUtnW_Zf_A5qFdZY</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Gallo Marin, Benjamin</creator><creator>Aghagoli, Ghazal</creator><creator>Hu, Susie L.</creator><creator>Massoud, Cathy M.</creator><creator>Robinson-Bostom, Leslie</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202302</creationdate><title>Calciphylaxis and Kidney Disease: A Review</title><author>Gallo Marin, Benjamin ; Aghagoli, Ghazal ; Hu, Susie L. ; Massoud, Cathy M. ; Robinson-Bostom, Leslie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-a8277fe4d08383e4eccd1dfe6ed1c25926b970e32c85996a924ad0ac1e3293953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>calcific uremic arteriolopathy</topic><topic>Calciphylaxis</topic><topic>Calciphylaxis - diagnosis</topic><topic>Calciphylaxis - etiology</topic><topic>Calciphylaxis - therapy</topic><topic>Calcium</topic><topic>calcium apatite</topic><topic>dermatologic lesion</topic><topic>dialysis</topic><topic>end-stage renal disease (ESRD)</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>microvascular calcification</topic><topic>Obesity - complications</topic><topic>pain management</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>review</topic><topic>sodium thiosulfate (STS)</topic><topic>Vascular Calcification - etiology</topic><topic>vasculopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallo Marin, Benjamin</creatorcontrib><creatorcontrib>Aghagoli, Ghazal</creatorcontrib><creatorcontrib>Hu, Susie L.</creatorcontrib><creatorcontrib>Massoud, Cathy M.</creatorcontrib><creatorcontrib>Robinson-Bostom, Leslie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallo Marin, Benjamin</au><au>Aghagoli, Ghazal</au><au>Hu, Susie L.</au><au>Massoud, Cathy M.</au><au>Robinson-Bostom, Leslie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calciphylaxis and Kidney Disease: A Review</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>2023-02</date><risdate>2023</risdate><volume>81</volume><issue>2</issue><spage>232</spage><epage>239</epage><pages>232-239</pages><issn>0272-6386</issn><eissn>1523-6838</eissn><abstract>Calciphylaxis is a life-threatening complication most often associated with chronic kidney disease that occurs as a result of the deposition of calcium in dermal and adipose microvasculature. However, this condition may also be seen in patients with acute kidney injury. The high morbidity and mortality rates associated with calciphylaxis highlight the importance to correctly diagnose and treat this condition. However, calciphylaxis remains a diagnosis that may be clinically challenging to make. Here, we review the literature on uremic calciphylaxis with a focus on its pathophysiology, clinical presentation, advances in diagnostic tools, and treatment strategies. We also discuss the unique histopathological features of calciphylaxis and contrast it with those of other forms of general vessel calcification. 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| ispartof | American journal of kidney diseases, 2023-02, Vol.81 (2), p.232-239 |
| issn | 0272-6386 1523-6838 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | calcific uremic arteriolopathy Calciphylaxis Calciphylaxis - diagnosis Calciphylaxis - etiology Calciphylaxis - therapy Calcium calcium apatite dermatologic lesion dialysis end-stage renal disease (ESRD) Humans Kidney Failure, Chronic - therapy microvascular calcification Obesity - complications pain management Renal Insufficiency, Chronic - complications review sodium thiosulfate (STS) Vascular Calcification - etiology vasculopathy |
| title | Calciphylaxis and Kidney Disease: A Review |
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