Sex differences in prevalence and clinical correlates of insomnia in Chinese patients with chronic schizophrenia
Objective It is generally recognized that there are sex differences in many aspects of schizophrenia. The main purpose of this study was to investigate the sex differences in the prevalence and clinical correlates of insomnia in patients with chronic schizophrenia. Methods A total of 957 patients wh...
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| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 2023-04, Vol.273 (3), p.601-611 |
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| creator | Zhu, Rongrong Wang, Dongmei Zhou, Huixia Wang, Wenjia Wei, Shuochi Chen, Dachun Xiu, Meihong Wang, Li Zhang, Xiang-Yang |
| description | Objective
It is generally recognized that there are sex differences in many aspects of schizophrenia. The main purpose of this study was to investigate the sex differences in the prevalence and clinical correlates of insomnia in patients with chronic schizophrenia.
Methods
A total of 957 patients who met the DSM-IV diagnostic criteria for schizophrenia were recruited in this cross-sectional study (male/female = 630/327). Demographic, clinical, and insomnia data were collected using self-reported questionnaires. Fasting blood samples were collected to evaluate the status of blood lipids. Psychopathological symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS).
Results
The prevalence rate of insomnia in female patients with schizophrenia was significantly higher than that in male patients (17.3% for males and 26.3% for females;
χ
2
= 10.74,
p
= 0.001). Regression analysis showed that in male patients, insomnia was independently associated with severe PANSS positive symptoms, severe PANSS depressive factor, and high levels of low-density lipoprotein levels, while in female patients, insomnia was associated with low education level, high PANSS depressive factor, and high levels of apolipoprotein B levels.
Conclusion
This study illustrates that insomnia is more frequent in female than male schizophrenia patients, and that there are differences in the clinical correlates of insomnia by sex, suggesting that sex differences should be considered in prevention and treatment strategies for coexisting insomnia in schizophrenia patients. |
| doi_str_mv | 10.1007/s00406-022-01473-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2702975874</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2798861267</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-83237a8a31f22fc4a25e56642a7986f8321d86fa5abb8a827f7a7d392502f5d43</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhoMo7uzqH_AgAS9eWitfnfRRBr9gwYN6DjXpxM7Sk7RJjzv66804q4IHT0Wo530r8BDyhMELBqBfVgAJfQecd8CkFt3xHtkwKURn5MDukw0MEjomhLwgl7XeAABTHB6SC6EGzZVSG7J89Ec6xhB88cn5SmOiS_HfcD49KaaRujmm6HCmLpfiZ1wblUMDa96niKfEdorJV08XXKNPa6W3cZ2om0puSVrdFH_kZWoXIj4iDwLO1T--m1fk85vXn7bvuusPb99vX113Tmi1dkZwodGgYIHz4CRy5VXfS456MH1oaza2iQp3O4OG66BRj2LgCnhQoxRX5Pm5dyn568HX1e5jdX6eMfl8qJZr4INWRp_QZ_-gN_lQUvtdowZjesZ73Sh-plzJtRYf7FLiHst3y8CefNizD9t82F8-7LGFnt5VH3Z7P_6J_BbQAHEGalulL778vf2f2p8ftZbk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2798861267</pqid></control><display><type>article</type><title>Sex differences in prevalence and clinical correlates of insomnia in Chinese patients with chronic schizophrenia</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Zhu, Rongrong ; Wang, Dongmei ; Zhou, Huixia ; Wang, Wenjia ; Wei, Shuochi ; Chen, Dachun ; Xiu, Meihong ; Wang, Li ; Zhang, Xiang-Yang</creator><creatorcontrib>Zhu, Rongrong ; Wang, Dongmei ; Zhou, Huixia ; Wang, Wenjia ; Wei, Shuochi ; Chen, Dachun ; Xiu, Meihong ; Wang, Li ; Zhang, Xiang-Yang</creatorcontrib><description>Objective
It is generally recognized that there are sex differences in many aspects of schizophrenia. The main purpose of this study was to investigate the sex differences in the prevalence and clinical correlates of insomnia in patients with chronic schizophrenia.
Methods
A total of 957 patients who met the DSM-IV diagnostic criteria for schizophrenia were recruited in this cross-sectional study (male/female = 630/327). Demographic, clinical, and insomnia data were collected using self-reported questionnaires. Fasting blood samples were collected to evaluate the status of blood lipids. Psychopathological symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS).
Results
The prevalence rate of insomnia in female patients with schizophrenia was significantly higher than that in male patients (17.3% for males and 26.3% for females;
χ
2
= 10.74,
p
= 0.001). Regression analysis showed that in male patients, insomnia was independently associated with severe PANSS positive symptoms, severe PANSS depressive factor, and high levels of low-density lipoprotein levels, while in female patients, insomnia was associated with low education level, high PANSS depressive factor, and high levels of apolipoprotein B levels.
Conclusion
This study illustrates that insomnia is more frequent in female than male schizophrenia patients, and that there are differences in the clinical correlates of insomnia by sex, suggesting that sex differences should be considered in prevention and treatment strategies for coexisting insomnia in schizophrenia patients.</description><identifier>ISSN: 0940-1334</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/s00406-022-01473-x</identifier><identifier>PMID: 35972555</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Apolipoprotein B ; Cross-Sectional Studies ; East Asian People ; Female ; Females ; Gender differences ; Humans ; Insomnia ; Lipids ; Male ; Males ; Medicine ; Medicine & Public Health ; Mental disorders ; Neurosciences ; Original Paper ; Patients ; Prevalence ; Psychiatry ; Schizophrenia ; Schizophrenia - complications ; Schizophrenia - diagnosis ; Schizophrenia - epidemiology ; Sex Characteristics ; Sex differences ; Sleep disorders ; Sleep Initiation and Maintenance Disorders - epidemiology</subject><ispartof>European archives of psychiatry and clinical neuroscience, 2023-04, Vol.273 (3), p.601-611</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-83237a8a31f22fc4a25e56642a7986f8321d86fa5abb8a827f7a7d392502f5d43</citedby><cites>FETCH-LOGICAL-c375t-83237a8a31f22fc4a25e56642a7986f8321d86fa5abb8a827f7a7d392502f5d43</cites><orcidid>0000-0003-3326-382X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00406-022-01473-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00406-022-01473-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35972555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Rongrong</creatorcontrib><creatorcontrib>Wang, Dongmei</creatorcontrib><creatorcontrib>Zhou, Huixia</creatorcontrib><creatorcontrib>Wang, Wenjia</creatorcontrib><creatorcontrib>Wei, Shuochi</creatorcontrib><creatorcontrib>Chen, Dachun</creatorcontrib><creatorcontrib>Xiu, Meihong</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Zhang, Xiang-Yang</creatorcontrib><title>Sex differences in prevalence and clinical correlates of insomnia in Chinese patients with chronic schizophrenia</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description>Objective
It is generally recognized that there are sex differences in many aspects of schizophrenia. The main purpose of this study was to investigate the sex differences in the prevalence and clinical correlates of insomnia in patients with chronic schizophrenia.
Methods
A total of 957 patients who met the DSM-IV diagnostic criteria for schizophrenia were recruited in this cross-sectional study (male/female = 630/327). Demographic, clinical, and insomnia data were collected using self-reported questionnaires. Fasting blood samples were collected to evaluate the status of blood lipids. Psychopathological symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS).
Results
The prevalence rate of insomnia in female patients with schizophrenia was significantly higher than that in male patients (17.3% for males and 26.3% for females;
χ
2
= 10.74,
p
= 0.001). Regression analysis showed that in male patients, insomnia was independently associated with severe PANSS positive symptoms, severe PANSS depressive factor, and high levels of low-density lipoprotein levels, while in female patients, insomnia was associated with low education level, high PANSS depressive factor, and high levels of apolipoprotein B levels.
Conclusion
This study illustrates that insomnia is more frequent in female than male schizophrenia patients, and that there are differences in the clinical correlates of insomnia by sex, suggesting that sex differences should be considered in prevention and treatment strategies for coexisting insomnia in schizophrenia patients.</description><subject>Apolipoprotein B</subject><subject>Cross-Sectional Studies</subject><subject>East Asian People</subject><subject>Female</subject><subject>Females</subject><subject>Gender differences</subject><subject>Humans</subject><subject>Insomnia</subject><subject>Lipids</subject><subject>Male</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Prevalence</subject><subject>Psychiatry</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - epidemiology</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Sleep disorders</subject><subject>Sleep Initiation and Maintenance Disorders - epidemiology</subject><issn>0940-1334</issn><issn>1433-8491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU2LFDEQhoMo7uzqH_AgAS9eWitfnfRRBr9gwYN6DjXpxM7Sk7RJjzv66804q4IHT0Wo530r8BDyhMELBqBfVgAJfQecd8CkFt3xHtkwKURn5MDukw0MEjomhLwgl7XeAABTHB6SC6EGzZVSG7J89Ec6xhB88cn5SmOiS_HfcD49KaaRujmm6HCmLpfiZ1wblUMDa96niKfEdorJV08XXKNPa6W3cZ2om0puSVrdFH_kZWoXIj4iDwLO1T--m1fk85vXn7bvuusPb99vX113Tmi1dkZwodGgYIHz4CRy5VXfS456MH1oaza2iQp3O4OG66BRj2LgCnhQoxRX5Pm5dyn568HX1e5jdX6eMfl8qJZr4INWRp_QZ_-gN_lQUvtdowZjesZ73Sh-plzJtRYf7FLiHst3y8CefNizD9t82F8-7LGFnt5VH3Z7P_6J_BbQAHEGalulL778vf2f2p8ftZbk</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Zhu, Rongrong</creator><creator>Wang, Dongmei</creator><creator>Zhou, Huixia</creator><creator>Wang, Wenjia</creator><creator>Wei, Shuochi</creator><creator>Chen, Dachun</creator><creator>Xiu, Meihong</creator><creator>Wang, Li</creator><creator>Zhang, Xiang-Yang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3326-382X</orcidid></search><sort><creationdate>20230401</creationdate><title>Sex differences in prevalence and clinical correlates of insomnia in Chinese patients with chronic schizophrenia</title><author>Zhu, Rongrong ; Wang, Dongmei ; Zhou, Huixia ; Wang, Wenjia ; Wei, Shuochi ; Chen, Dachun ; Xiu, Meihong ; Wang, Li ; Zhang, Xiang-Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-83237a8a31f22fc4a25e56642a7986f8321d86fa5abb8a827f7a7d392502f5d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Apolipoprotein B</topic><topic>Cross-Sectional Studies</topic><topic>East Asian People</topic><topic>Female</topic><topic>Females</topic><topic>Gender differences</topic><topic>Humans</topic><topic>Insomnia</topic><topic>Lipids</topic><topic>Male</topic><topic>Males</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental disorders</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Prevalence</topic><topic>Psychiatry</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - epidemiology</topic><topic>Sex Characteristics</topic><topic>Sex differences</topic><topic>Sleep disorders</topic><topic>Sleep Initiation and Maintenance Disorders - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Rongrong</creatorcontrib><creatorcontrib>Wang, Dongmei</creatorcontrib><creatorcontrib>Zhou, Huixia</creatorcontrib><creatorcontrib>Wang, Wenjia</creatorcontrib><creatorcontrib>Wei, Shuochi</creatorcontrib><creatorcontrib>Chen, Dachun</creatorcontrib><creatorcontrib>Xiu, Meihong</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Zhang, Xiang-Yang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of psychiatry and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Rongrong</au><au>Wang, Dongmei</au><au>Zhou, Huixia</au><au>Wang, Wenjia</au><au>Wei, Shuochi</au><au>Chen, Dachun</au><au>Xiu, Meihong</au><au>Wang, Li</au><au>Zhang, Xiang-Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in prevalence and clinical correlates of insomnia in Chinese patients with chronic schizophrenia</atitle><jtitle>European archives of psychiatry and clinical neuroscience</jtitle><stitle>Eur Arch Psychiatry Clin Neurosci</stitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>273</volume><issue>3</issue><spage>601</spage><epage>611</epage><pages>601-611</pages><issn>0940-1334</issn><eissn>1433-8491</eissn><abstract>Objective
It is generally recognized that there are sex differences in many aspects of schizophrenia. The main purpose of this study was to investigate the sex differences in the prevalence and clinical correlates of insomnia in patients with chronic schizophrenia.
Methods
A total of 957 patients who met the DSM-IV diagnostic criteria for schizophrenia were recruited in this cross-sectional study (male/female = 630/327). Demographic, clinical, and insomnia data were collected using self-reported questionnaires. Fasting blood samples were collected to evaluate the status of blood lipids. Psychopathological symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS).
Results
The prevalence rate of insomnia in female patients with schizophrenia was significantly higher than that in male patients (17.3% for males and 26.3% for females;
χ
2
= 10.74,
p
= 0.001). Regression analysis showed that in male patients, insomnia was independently associated with severe PANSS positive symptoms, severe PANSS depressive factor, and high levels of low-density lipoprotein levels, while in female patients, insomnia was associated with low education level, high PANSS depressive factor, and high levels of apolipoprotein B levels.
Conclusion
This study illustrates that insomnia is more frequent in female than male schizophrenia patients, and that there are differences in the clinical correlates of insomnia by sex, suggesting that sex differences should be considered in prevention and treatment strategies for coexisting insomnia in schizophrenia patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35972555</pmid><doi>10.1007/s00406-022-01473-x</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3326-382X</orcidid></addata></record> |
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| ispartof | European archives of psychiatry and clinical neuroscience, 2023-04, Vol.273 (3), p.601-611 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Apolipoprotein B Cross-Sectional Studies East Asian People Female Females Gender differences Humans Insomnia Lipids Male Males Medicine Medicine & Public Health Mental disorders Neurosciences Original Paper Patients Prevalence Psychiatry Schizophrenia Schizophrenia - complications Schizophrenia - diagnosis Schizophrenia - epidemiology Sex Characteristics Sex differences Sleep disorders Sleep Initiation and Maintenance Disorders - epidemiology |
| title | Sex differences in prevalence and clinical correlates of insomnia in Chinese patients with chronic schizophrenia |
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