A one-photon endoscope for simultaneous patterned optogenetic stimulation and calcium imaging in freely behaving mice

Optogenetics and calcium imaging can be combined to simultaneously stimulate and record neural activity in vivo. However, this usually requires two-photon microscopes, which are not portable nor affordable. Here we report the design and implementation of a miniaturized one-photon endoscope for perfo...

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Veröffentlicht in:	Nature biomedical engineering 2023-04, Vol.7 (4), p.499-510
Hauptverfasser:	Zhang, Jinyong, Hughes, Ryan N., Kim, Namsoo, Fallon, Isabella P., Bakhurin, Konstantin, Kim, Jiwon, Severino, Francesco Paolo Ulloa, Yin, Henry H.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2632/1323 631/378/3920 64/60 Animals Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Calcium Calcium - metabolism Calcium imaging Digital imaging Endoscopes Genetics Information processing Mice Microscopes Microscopy - methods Neostriatum Neurons Neurons - physiology Optics Optogenetics - methods Photons Stimulation Visual field
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