Time-restricted feeding during embryonic development leads to metabolic dysfunction in adult rat offspring
•Maternal time-restricted feeding (TRF) during pregnancy leads to changes in offspring metabolism•TRF impairs glucose homeostasis and the lipid profile of adult offspring•Female offspring are more susceptible to maternal TRF•Glucose-induced insulin secretion is diminished in islets of adult offsprin...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2022-11, Vol.103-104, p.111776-111776, Article 111776 |
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| container_title | Nutrition (Burbank, Los Angeles County, Calif.) |
| container_volume | 103-104 |
| creator | Prates, Kelly Valério Pavanello, Audrei Gongora, Adriane Barreto Moreira, Veridiana Mota de Moraes, Ana Maria Praxedes Rigo, Kesia Palma Vieira, Elaine Mathias, Paulo Cezar de Freitas |
| description | •Maternal time-restricted feeding (TRF) during pregnancy leads to changes in offspring metabolism•TRF impairs glucose homeostasis and the lipid profile of adult offspring•Female offspring are more susceptible to maternal TRF•Glucose-induced insulin secretion is diminished in islets of adult offspring•The adrenergic response in pancreatic β-cells is sex-dependent
Maternal circadian eating time and frequency are associated with altered glucose metabolism during pregnancy in humans. Research on long maternal fasting intervals is inconclusive, and little is known about the effect of maternal time feeding on offspring health. Therefore, the aim of the present study is to determine whether maternal time feeding influences the metabolic status of both male and female offspring.
Pregnant rats were provided ad libitum access to chow diet or fed during either the light phase (LP) or dark phase (DP) during embryonic development. At the age of 150 days, glucose tolerance, lipid concentrations, and insulin secretion were determined in adult male and female offspring.
Both male and female offspring of LP and DP dams exhibited alterations in the lipid profile, and female offspring were glucose intolerant. Glucose-stimulated insulin secretion decreased in male and female offspring of LP and DP dams. Acetylcholine increased insulin secretion in male and female offspring. Islets from male and female offspring of DP dams exhibited less pronounced inhibition of insulin secretion by epinephrine, suggesting alterations in the cholinergic and adrenergic pathways in these animals.
Our data suggest that a time-restricted feeding regimen during embryonic development could program rat offspring for metabolic dysfunction during adulthood. |
| doi_str_mv | 10.1016/j.nut.2022.111776 |
| format | Article |
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Maternal circadian eating time and frequency are associated with altered glucose metabolism during pregnancy in humans. Research on long maternal fasting intervals is inconclusive, and little is known about the effect of maternal time feeding on offspring health. Therefore, the aim of the present study is to determine whether maternal time feeding influences the metabolic status of both male and female offspring.
Pregnant rats were provided ad libitum access to chow diet or fed during either the light phase (LP) or dark phase (DP) during embryonic development. At the age of 150 days, glucose tolerance, lipid concentrations, and insulin secretion were determined in adult male and female offspring.
Both male and female offspring of LP and DP dams exhibited alterations in the lipid profile, and female offspring were glucose intolerant. Glucose-stimulated insulin secretion decreased in male and female offspring of LP and DP dams. Acetylcholine increased insulin secretion in male and female offspring. Islets from male and female offspring of DP dams exhibited less pronounced inhibition of insulin secretion by epinephrine, suggesting alterations in the cholinergic and adrenergic pathways in these animals.
Our data suggest that a time-restricted feeding regimen during embryonic development could program rat offspring for metabolic dysfunction during adulthood.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2022.111776</identifier><language>eng</language><publisher>Kidlington: Elsevier Inc</publisher><subject>Cholesterol ; Cholinergics ; Circadian rhythms ; Diet ; Embryogenesis ; Embryonic development ; Embryonic growth stage ; Energy ; Epinephrine ; Females ; Food ; Glucose ; Glucose metabolism ; Glucose tolerance ; Insulin ; Insulin secretion ; Laboratory animals ; Light ; Lipids ; Males ; Metabolism ; Mothers ; Obesity ; Offspring ; Plasma ; Pregnancy ; Rodents ; Secretion ; Triglycerides ; Weaning ; Weight control ; Womens health</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2022-11, Vol.103-104, p.111776-111776, Article 111776</ispartof><rights>2022 Elsevier Inc.</rights><rights>2022. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-d30d4a9c9e7464ea32451c58ee8acfebd9956a437d54230c4bb6dd3bd044296e3</citedby><cites>FETCH-LOGICAL-c401t-d30d4a9c9e7464ea32451c58ee8acfebd9956a437d54230c4bb6dd3bd044296e3</cites><orcidid>0000-0003-0516-3004 ; 0000-0002-6031-8219 ; 0000-0003-3770-4493</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2731058039?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids></links><search><creatorcontrib>Prates, Kelly Valério</creatorcontrib><creatorcontrib>Pavanello, Audrei</creatorcontrib><creatorcontrib>Gongora, Adriane Barreto</creatorcontrib><creatorcontrib>Moreira, Veridiana Mota</creatorcontrib><creatorcontrib>de Moraes, Ana Maria Praxedes</creatorcontrib><creatorcontrib>Rigo, Kesia Palma</creatorcontrib><creatorcontrib>Vieira, Elaine</creatorcontrib><creatorcontrib>Mathias, Paulo Cezar de Freitas</creatorcontrib><title>Time-restricted feeding during embryonic development leads to metabolic dysfunction in adult rat offspring</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><description>•Maternal time-restricted feeding (TRF) during pregnancy leads to changes in offspring metabolism•TRF impairs glucose homeostasis and the lipid profile of adult offspring•Female offspring are more susceptible to maternal TRF•Glucose-induced insulin secretion is diminished in islets of adult offspring•The adrenergic response in pancreatic β-cells is sex-dependent
Maternal circadian eating time and frequency are associated with altered glucose metabolism during pregnancy in humans. Research on long maternal fasting intervals is inconclusive, and little is known about the effect of maternal time feeding on offspring health. Therefore, the aim of the present study is to determine whether maternal time feeding influences the metabolic status of both male and female offspring.
Pregnant rats were provided ad libitum access to chow diet or fed during either the light phase (LP) or dark phase (DP) during embryonic development. At the age of 150 days, glucose tolerance, lipid concentrations, and insulin secretion were determined in adult male and female offspring.
Both male and female offspring of LP and DP dams exhibited alterations in the lipid profile, and female offspring were glucose intolerant. Glucose-stimulated insulin secretion decreased in male and female offspring of LP and DP dams. Acetylcholine increased insulin secretion in male and female offspring. Islets from male and female offspring of DP dams exhibited less pronounced inhibition of insulin secretion by epinephrine, suggesting alterations in the cholinergic and adrenergic pathways in these animals.
Our data suggest that a time-restricted feeding regimen during embryonic development could program rat offspring for metabolic dysfunction during adulthood.</description><subject>Cholesterol</subject><subject>Cholinergics</subject><subject>Circadian rhythms</subject><subject>Diet</subject><subject>Embryogenesis</subject><subject>Embryonic development</subject><subject>Embryonic growth stage</subject><subject>Energy</subject><subject>Epinephrine</subject><subject>Females</subject><subject>Food</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glucose tolerance</subject><subject>Insulin</subject><subject>Insulin secretion</subject><subject>Laboratory animals</subject><subject>Light</subject><subject>Lipids</subject><subject>Males</subject><subject>Metabolism</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Offspring</subject><subject>Plasma</subject><subject>Pregnancy</subject><subject>Rodents</subject><subject>Secretion</subject><subject>Triglycerides</subject><subject>Weaning</subject><subject>Weight control</subject><subject>Womens 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prates, Kelly Valério</au><au>Pavanello, Audrei</au><au>Gongora, Adriane Barreto</au><au>Moreira, Veridiana Mota</au><au>de Moraes, Ana Maria Praxedes</au><au>Rigo, Kesia Palma</au><au>Vieira, Elaine</au><au>Mathias, Paulo Cezar de Freitas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time-restricted feeding during embryonic development leads to metabolic dysfunction in adult rat offspring</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><date>2022-11</date><risdate>2022</risdate><volume>103-104</volume><spage>111776</spage><epage>111776</epage><pages>111776-111776</pages><artnum>111776</artnum><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract>•Maternal time-restricted feeding (TRF) during pregnancy leads to changes in offspring metabolism•TRF impairs glucose homeostasis and the lipid profile of adult offspring•Female offspring are more susceptible to maternal TRF•Glucose-induced insulin secretion is diminished in islets of adult offspring•The adrenergic response in pancreatic β-cells is sex-dependent
Maternal circadian eating time and frequency are associated with altered glucose metabolism during pregnancy in humans. Research on long maternal fasting intervals is inconclusive, and little is known about the effect of maternal time feeding on offspring health. Therefore, the aim of the present study is to determine whether maternal time feeding influences the metabolic status of both male and female offspring.
Pregnant rats were provided ad libitum access to chow diet or fed during either the light phase (LP) or dark phase (DP) during embryonic development. At the age of 150 days, glucose tolerance, lipid concentrations, and insulin secretion were determined in adult male and female offspring.
Both male and female offspring of LP and DP dams exhibited alterations in the lipid profile, and female offspring were glucose intolerant. Glucose-stimulated insulin secretion decreased in male and female offspring of LP and DP dams. Acetylcholine increased insulin secretion in male and female offspring. Islets from male and female offspring of DP dams exhibited less pronounced inhibition of insulin secretion by epinephrine, suggesting alterations in the cholinergic and adrenergic pathways in these animals.
Our data suggest that a time-restricted feeding regimen during embryonic development could program rat offspring for metabolic dysfunction during adulthood.</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><doi>10.1016/j.nut.2022.111776</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0516-3004</orcidid><orcidid>https://orcid.org/0000-0002-6031-8219</orcidid><orcidid>https://orcid.org/0000-0003-3770-4493</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0899-9007 |
| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2022-11, Vol.103-104, p.111776-111776, Article 111776 |
| issn | 0899-9007 1873-1244 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2702486161 |
| source | Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Cholesterol Cholinergics Circadian rhythms Diet Embryogenesis Embryonic development Embryonic growth stage Energy Epinephrine Females Food Glucose Glucose metabolism Glucose tolerance Insulin Insulin secretion Laboratory animals Light Lipids Males Metabolism Mothers Obesity Offspring Plasma Pregnancy Rodents Secretion Triglycerides Weaning Weight control Womens health |
| title | Time-restricted feeding during embryonic development leads to metabolic dysfunction in adult rat offspring |
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