Conversion of proteins into DNA mimetics by lipid peroxidation

Conversion of proteins into DNA mimetics by lipid peroxidation

Conversion of primary amino groups to pyrrole derivatives occurs by modifying lysine residues of proteins with lipid peroxidation products. Pyrrolated proteins exhibit electronegativity and electronic properties and are recognized by DNA-binding molecules, such as anti-DNA autoantibodies and DNA int...

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Veröffentlicht in:Archives of biochemistry and biophysics 2022-10, Vol.728, p.109374-109374, Article 109374
1. Verfasser: Uchida, Koji
Format: Artikel
Sprache:eng
Schlagworte:
Anti-DNA autoantibodies
DNA mimic Proteins
Lipid peroxidation
Protein N-Pyrrolation
γ-ketoaldehydes
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Zusammenfassung:Conversion of primary amino groups to pyrrole derivatives occurs by modifying lysine residues of proteins with lipid peroxidation products. Pyrrolated proteins exhibit electronegativity and electronic properties and are recognized by DNA-binding molecules, such as anti-DNA autoantibodies and DNA intercalators. This review summarizes the state of knowledge about the chemistry of this unique conversion reaction of proteins into DNA mimetics by lipid peroxidation.
ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2022.109374