Design, synthesis, and characterization of novel fluorogenic substrates of the proprotein convertases furin, PC1/3, PC2, PC5/6, and PC7

Proprotein convertases (PCs) are involved in the pathogenesis of various diseases, making them promising drug targets. Most assays for PCs have been performed with few standard substrates, regardless of differences in cleavage efficiencies. Derived from studies on substrate-analogue inhibitors, 11 n...

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Veröffentlicht in:	Analytical biochemistry 2022-10, Vol.655, p.114836-114836, Article 114836
Hauptverfasser:	Lam van, Thuy Van, Ivanova, Teodora, Lindberg, Iris, Böttcher-Friebertshäuser, Eva, Steinmetzer, Torsten, Hardes, Kornelia
Format:	Artikel
Sprache:	eng
Schlagworte:	Fluorogenic substrates Furin PC1/3 PC2 PC5/6 PC7 Proprotein convertases
Online-Zugang:	Volltext
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