PD1 blockade alters cell-cycle distribution and affects 3′-deoxy-3′-[18F]fluorothymidine uptake in a mouse CT26 tumor model

Objective We previously reported that alterations of the tumor microenvironment (TME) by programmed death receptor-1 (PD1) blockade affected tumor glucose metabolism and tumor 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]FDG) uptake. In cancer cells, high glycolysis allows cells to sustain rapid prolif...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of nuclear medicine 2022-11, Vol.36 (11), p.931-940
Hauptverfasser:	Suzuki, Motofumi, Matsuda, Takuma, Nakajima, Kohei, Yokouchi, Yuta, Kuge, Yuji, Ogawa, Mikako
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Autoradiography Cancer CD4 antigen CD8 antigen Cell proliferation Colon Colorectal cancer Cytokines Flow cytometry Fluorine isotopes Glucose Glucose metabolism Glycolysis Imaging Immunohistochemistry Immunotherapy Interferon Interleukin 2 Interleukins Kinases Localization Lymphocytes Lymphocytes T Medical imaging Medicine Medicine & Public Health Nuclear Medicine Original Article PD-1 protein Positron emission Positron emission tomography Radiology Thymidine Thymidine kinase Tumor cells Tumor microenvironment Tumor necrosis factor-TNF Tumor necrosis factor-α Tumor-infiltrating lymphocytes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!