Kinetic and mechanism study of the spontaneous, solvent- and base-catalyzed degradation of the precursor of the β-nitro alcohol metaraminol by combining HPLC/electronic circular dichroism/theoretical methods

Chiral β-nitro alcohols are key intermediates in the synthesis of a wide range of active pharmaceutical ingredients. Despite their massive use for pharmaceutical applications, in-depth kinetics studies concerning their stability during formation and transformation reactions are scarce in the literat...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2022-10, Vol.220, p.114972-114972, Article 114972
Hauptverfasser:	Cantatore, Chiara, Visconti, Paolo, Pierini, Marco, Cirilli, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Circular dichroism Degradation kinetics Enantio- and diastereo-selective HPLC Metaraminol Theoretical calculations β-nitro alcohol
Online-Zugang:	Volltext
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