Intraoperative radiotherapy versus no radiotherapy for early stage low-risk breast cancer patients undergoing breast-conserving surgery: a propensity score matching study based on the SEER database
Purpose To compare the effect of intraoperative radiotherapy (IORT) and no radiotherapy in early stage low-risk breast cancer patients undergoing breast-conserving surgery. Methods According to the criteria recommended by ASTRO for patients eligible for IORT, we retrospectively selected women with e...
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| Veröffentlicht in: | Clinical & translational oncology 2022-12, Vol.24 (12), p.2409-2419 |
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| creator | Mi, Yin Zuo, Xiaoxiao Cao, Qinchen He, Juanjuan Sui, Xin Li, Jing Cui, Kang Ma, Xiaoxu Zhang, Nan Shi, Yonggang |
| description | Purpose
To compare the effect of intraoperative radiotherapy (IORT) and no radiotherapy in early stage low-risk breast cancer patients undergoing breast-conserving surgery.
Methods
According to the criteria recommended by ASTRO for patients eligible for IORT, we retrospectively selected women with early stage low-risk breast cancer who underwent breast-conserving surgery from 2010 to 2019 from the SEER database. Propensity score matching was used to balance the differences in baseline characteristics. The Kaplan–Meier method was used to calculate the overall survival (OS) and breast cancer-specific survival (BCSS) of patients, and the log-rank test was used to compare the differences.
Results
A total of 20,245 patients were included in the analysis, including 1738 in the IORT group and 18,507 in the no radiotherapy group, with a median follow-up of 41 months. Before matching, the 5-year OS rates of the IORT group and the no radiotherapy group were 95.5% and 85.7% (
p
|
| doi_str_mv | 10.1007/s12094-022-02911-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2702183415</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2702183415</sourcerecordid><originalsourceid>FETCH-LOGICAL-c275t-ca509a62ea7d375d9b97749aa9b676ef30694d5fc2bce1aabb2236b277fcf4a43</originalsourceid><addsrcrecordid>eNp9UU1v1DAUjBBIlNI_0JOPXAK282HMDVULVKqE1Jaz9eK8bFOydnjPWZofyP_C2-2BXjhYfh7NjMeeojhX8r2S0nxgpaWtS6l1Xlap8uFFcaJaa8tKNs3Lf-bXxRvme5mnVqmT4s9lSARxRoI07lEQ9GNMd_k4r2KPxAuLEJ_DQySBQNMqOMEWxRR_lzTyT9ERAifhIXgkMWdHDInFEnqkbRzD9olR-hgYaX9AeKEt0vpJgJgp5wg8pmzsI6HYQfJ3j6S09KvogLEXMYgcRNxsNteihwQH9G3xaoCJ8expPy1-fNncXnwrr75_vbz4fFV6bZp8LTTSQqsRTF-ZpredNaa2ALZrTYtDJVtb983gdedRAXSd1lXbaWMGP9RQV6fFu6NvjvprQU5uN7LHaYKAcWGnjdTqY1WrJlP1keopMhMObqZxB7Q6Jd2hM3fszOXO3GNn7iGLqqOIMznkf3H3caGQn_Q_1V8Wi6Gk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2702183415</pqid></control><display><type>article</type><title>Intraoperative radiotherapy versus no radiotherapy for early stage low-risk breast cancer patients undergoing breast-conserving surgery: a propensity score matching study based on the SEER database</title><source>Springer Nature - Complete Springer Journals</source><creator>Mi, Yin ; Zuo, Xiaoxiao ; Cao, Qinchen ; He, Juanjuan ; Sui, Xin ; Li, Jing ; Cui, Kang ; Ma, Xiaoxu ; Zhang, Nan ; Shi, Yonggang</creator><creatorcontrib>Mi, Yin ; Zuo, Xiaoxiao ; Cao, Qinchen ; He, Juanjuan ; Sui, Xin ; Li, Jing ; Cui, Kang ; Ma, Xiaoxu ; Zhang, Nan ; Shi, Yonggang</creatorcontrib><description>Purpose
To compare the effect of intraoperative radiotherapy (IORT) and no radiotherapy in early stage low-risk breast cancer patients undergoing breast-conserving surgery.
Methods
According to the criteria recommended by ASTRO for patients eligible for IORT, we retrospectively selected women with early stage low-risk breast cancer who underwent breast-conserving surgery from 2010 to 2019 from the SEER database. Propensity score matching was used to balance the differences in baseline characteristics. The Kaplan–Meier method was used to calculate the overall survival (OS) and breast cancer-specific survival (BCSS) of patients, and the log-rank test was used to compare the differences.
Results
A total of 20,245 patients were included in the analysis, including 1738 in the IORT group and 18,507 in the no radiotherapy group, with a median follow-up of 41 months. Before matching, the 5-year OS rates of the IORT group and the no radiotherapy group were 95.5% and 85.7% (
p
< 0.001), respectively, and the 5-year BCSS rates of the two groups were 99.6% and 98.3% (
p
< 0.001), respectively. After matching, the 5-year OS rates were 95.6% and 90.3% (
p
< 0.001) in the IORT group and the no radiotherapy group, respectively, and the 5-year BCSS rates were 99.5% and 99.1% (
p
= 0.028), respectively. Cox multivariate analysis of the original data showed that radiotherapy was an independent prognostic factor for both OS and BCSS (
p
< 0.05).
Conclusions
For patients aged 50 years or older with early stage low-risk breast cancer, IORT may be a better option, with improved BCSS compared to the elimination of radiotherapy. The study could not draw conclusions on OS, because underlying diseases may be unevenly distributed between the two groups.</description><identifier>ISSN: 1699-3055</identifier><identifier>EISSN: 1699-3055</identifier><identifier>DOI: 10.1007/s12094-022-02911-x</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Medicine ; Medicine & Public Health ; Oncology ; Research Article</subject><ispartof>Clinical & translational oncology, 2022-12, Vol.24 (12), p.2409-2419</ispartof><rights>The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO) 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c275t-ca509a62ea7d375d9b97749aa9b676ef30694d5fc2bce1aabb2236b277fcf4a43</cites><orcidid>0000-0003-3683-9177</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12094-022-02911-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12094-022-02911-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Mi, Yin</creatorcontrib><creatorcontrib>Zuo, Xiaoxiao</creatorcontrib><creatorcontrib>Cao, Qinchen</creatorcontrib><creatorcontrib>He, Juanjuan</creatorcontrib><creatorcontrib>Sui, Xin</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Cui, Kang</creatorcontrib><creatorcontrib>Ma, Xiaoxu</creatorcontrib><creatorcontrib>Zhang, Nan</creatorcontrib><creatorcontrib>Shi, Yonggang</creatorcontrib><title>Intraoperative radiotherapy versus no radiotherapy for early stage low-risk breast cancer patients undergoing breast-conserving surgery: a propensity score matching study based on the SEER database</title><title>Clinical & translational oncology</title><addtitle>Clin Transl Oncol</addtitle><description>Purpose
To compare the effect of intraoperative radiotherapy (IORT) and no radiotherapy in early stage low-risk breast cancer patients undergoing breast-conserving surgery.
Methods
According to the criteria recommended by ASTRO for patients eligible for IORT, we retrospectively selected women with early stage low-risk breast cancer who underwent breast-conserving surgery from 2010 to 2019 from the SEER database. Propensity score matching was used to balance the differences in baseline characteristics. The Kaplan–Meier method was used to calculate the overall survival (OS) and breast cancer-specific survival (BCSS) of patients, and the log-rank test was used to compare the differences.
Results
A total of 20,245 patients were included in the analysis, including 1738 in the IORT group and 18,507 in the no radiotherapy group, with a median follow-up of 41 months. Before matching, the 5-year OS rates of the IORT group and the no radiotherapy group were 95.5% and 85.7% (
p
< 0.001), respectively, and the 5-year BCSS rates of the two groups were 99.6% and 98.3% (
p
< 0.001), respectively. After matching, the 5-year OS rates were 95.6% and 90.3% (
p
< 0.001) in the IORT group and the no radiotherapy group, respectively, and the 5-year BCSS rates were 99.5% and 99.1% (
p
= 0.028), respectively. Cox multivariate analysis of the original data showed that radiotherapy was an independent prognostic factor for both OS and BCSS (
p
< 0.05).
Conclusions
For patients aged 50 years or older with early stage low-risk breast cancer, IORT may be a better option, with improved BCSS compared to the elimination of radiotherapy. The study could not draw conclusions on OS, because underlying diseases may be unevenly distributed between the two groups.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Research Article</subject><issn>1699-3055</issn><issn>1699-3055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9UU1v1DAUjBBIlNI_0JOPXAK282HMDVULVKqE1Jaz9eK8bFOydnjPWZofyP_C2-2BXjhYfh7NjMeeojhX8r2S0nxgpaWtS6l1Xlap8uFFcaJaa8tKNs3Lf-bXxRvme5mnVqmT4s9lSARxRoI07lEQ9GNMd_k4r2KPxAuLEJ_DQySBQNMqOMEWxRR_lzTyT9ERAifhIXgkMWdHDInFEnqkbRzD9olR-hgYaX9AeKEt0vpJgJgp5wg8pmzsI6HYQfJ3j6S09KvogLEXMYgcRNxsNteihwQH9G3xaoCJ8expPy1-fNncXnwrr75_vbz4fFV6bZp8LTTSQqsRTF-ZpredNaa2ALZrTYtDJVtb983gdedRAXSd1lXbaWMGP9RQV6fFu6NvjvprQU5uN7LHaYKAcWGnjdTqY1WrJlP1keopMhMObqZxB7Q6Jd2hM3fszOXO3GNn7iGLqqOIMznkf3H3caGQn_Q_1V8Wi6Gk</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Mi, Yin</creator><creator>Zuo, Xiaoxiao</creator><creator>Cao, Qinchen</creator><creator>He, Juanjuan</creator><creator>Sui, Xin</creator><creator>Li, Jing</creator><creator>Cui, Kang</creator><creator>Ma, Xiaoxu</creator><creator>Zhang, Nan</creator><creator>Shi, Yonggang</creator><general>Springer International Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3683-9177</orcidid></search><sort><creationdate>20221201</creationdate><title>Intraoperative radiotherapy versus no radiotherapy for early stage low-risk breast cancer patients undergoing breast-conserving surgery: a propensity score matching study based on the SEER database</title><author>Mi, Yin ; Zuo, Xiaoxiao ; Cao, Qinchen ; He, Juanjuan ; Sui, Xin ; Li, Jing ; Cui, Kang ; Ma, Xiaoxu ; Zhang, Nan ; Shi, Yonggang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-ca509a62ea7d375d9b97749aa9b676ef30694d5fc2bce1aabb2236b277fcf4a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mi, Yin</creatorcontrib><creatorcontrib>Zuo, Xiaoxiao</creatorcontrib><creatorcontrib>Cao, Qinchen</creatorcontrib><creatorcontrib>He, Juanjuan</creatorcontrib><creatorcontrib>Sui, Xin</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Cui, Kang</creatorcontrib><creatorcontrib>Ma, Xiaoxu</creatorcontrib><creatorcontrib>Zhang, Nan</creatorcontrib><creatorcontrib>Shi, Yonggang</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical & translational oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mi, Yin</au><au>Zuo, Xiaoxiao</au><au>Cao, Qinchen</au><au>He, Juanjuan</au><au>Sui, Xin</au><au>Li, Jing</au><au>Cui, Kang</au><au>Ma, Xiaoxu</au><au>Zhang, Nan</au><au>Shi, Yonggang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraoperative radiotherapy versus no radiotherapy for early stage low-risk breast cancer patients undergoing breast-conserving surgery: a propensity score matching study based on the SEER database</atitle><jtitle>Clinical & translational oncology</jtitle><stitle>Clin Transl Oncol</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>24</volume><issue>12</issue><spage>2409</spage><epage>2419</epage><pages>2409-2419</pages><issn>1699-3055</issn><eissn>1699-3055</eissn><abstract>Purpose
To compare the effect of intraoperative radiotherapy (IORT) and no radiotherapy in early stage low-risk breast cancer patients undergoing breast-conserving surgery.
Methods
According to the criteria recommended by ASTRO for patients eligible for IORT, we retrospectively selected women with early stage low-risk breast cancer who underwent breast-conserving surgery from 2010 to 2019 from the SEER database. Propensity score matching was used to balance the differences in baseline characteristics. The Kaplan–Meier method was used to calculate the overall survival (OS) and breast cancer-specific survival (BCSS) of patients, and the log-rank test was used to compare the differences.
Results
A total of 20,245 patients were included in the analysis, including 1738 in the IORT group and 18,507 in the no radiotherapy group, with a median follow-up of 41 months. Before matching, the 5-year OS rates of the IORT group and the no radiotherapy group were 95.5% and 85.7% (
p
< 0.001), respectively, and the 5-year BCSS rates of the two groups were 99.6% and 98.3% (
p
< 0.001), respectively. After matching, the 5-year OS rates were 95.6% and 90.3% (
p
< 0.001) in the IORT group and the no radiotherapy group, respectively, and the 5-year BCSS rates were 99.5% and 99.1% (
p
= 0.028), respectively. Cox multivariate analysis of the original data showed that radiotherapy was an independent prognostic factor for both OS and BCSS (
p
< 0.05).
Conclusions
For patients aged 50 years or older with early stage low-risk breast cancer, IORT may be a better option, with improved BCSS compared to the elimination of radiotherapy. The study could not draw conclusions on OS, because underlying diseases may be unevenly distributed between the two groups.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s12094-022-02911-x</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3683-9177</orcidid></addata></record> |
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| title | Intraoperative radiotherapy versus no radiotherapy for early stage low-risk breast cancer patients undergoing breast-conserving surgery: a propensity score matching study based on the SEER database |
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