Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors

[Display omitted] Based on the structure of an early lead identified in Deciphera’s proprietary compound collection of switch control kinase inhibitors and using a combination of medicinal chemistry guided structure activity relationships and structure-based drug design, a novel series of potent acy...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2022-10, Vol.74, p.128929-128929, Article 128929
Hauptverfasser:	Caldwell, Timothy M., Kaufman, Michael D., Wise, Scott C., Mi Ahn, Yu, Hood, Molly M., Lu, Wei-Ping, Patt, William C., Samarakoon, Thiwanka, Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen M., Bulfer, Stacie L., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl ureas Cancer CSF1R Kinase
Online-Zugang:	Volltext
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