Short-term biological variation of serum glial fibrillary acidic protein
Serum glial fibrillary acidic protein (GFAP) is an emerging biomarker for intracerebral diseases and is approved for clinical use in traumatic brain injury. GFAP is also being investigated for several other applications, where the GFAP changes are not always outstanding. It is thus essential for the...
Gespeichert in:
| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2022-10, Vol.60 (11), p.1813-1819 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1819 |
|---|---|
| container_issue | 11 |
| container_start_page | 1813 |
| container_title | Clinical chemistry and laboratory medicine |
| container_volume | 60 |
| creator | Christensen, Silje Hovden Hviid, Claus Vinter Bødker Madsen, Anne Tranberg Parkner, Tina Winther-Larsen, Anne |
| description | Serum glial fibrillary acidic protein (GFAP) is an emerging biomarker for intracerebral diseases and is approved for clinical use in traumatic brain injury. GFAP is also being investigated for several other applications, where the GFAP changes are not always outstanding. It is thus essential for the interpretation of GFAP to distinguish clinical relevant changes from natural occurring biological variation. This study aimed at estimating the biological variation of serum GFAP.Apparently healthy subjects (n=33) had blood sampled for three consecutive days. On the second day, blood was also drawn every third hour from 9 AM to 9 PM. Serum GFAP was measured by Single Molecule Array (Simoa™). Components of biological variation were estimated in a linear mixed-effects model.The overall median GFAP value was 92.5 pg/mL (range 34.4–260.3 pg/mL). The overall within– (CVI) and between-subject variations (CVG) were 9.7 and 39.5%. The reference change value was 36.9% for an increase. No day-to-day variation was observed, however semidiurnal variation was observed with increasing GFAP values between 9 AM and 12 PM (p |
| doi_str_mv | 10.1515/cclm-2022-0480 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2702178393</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2702178393</sourcerecordid><originalsourceid>FETCH-LOGICAL-c355t-a41077beb950a9b2222a5810882a1f1b7ca5d5d1afb601197e8bff2e49850df83</originalsourceid><addsrcrecordid>eNptkE1LAzEQhhdRsFavnhe8eEnN5KPJXgQpagXBg3oO2WxSU3abmuwq_fdmrSCIuWQgzzuZeYriHPAMOPArY9oOEUwIwkzig2ICjArEKIXD75qh-ZzAcXGS0hpj4JyJSbF8fguxR72NXVn70IaVN7otP3T0uvdhUwZXJhuHrly1Pj84X0fftjruSm184025jaG3fnNaHDndJnv2c0-L17vbl8USPT7dPyxuHpGhnPdIM8BC1LauONZVTfLRXAKWkmhwUAujecMb0K6eY4BKWFk7RyyrJMeNk3RaXO775n_fB5t61flkbB5pY8OQFBGYgJC0ohm9-IOuwxA3ebpMQcWEYIJnaranTAwpRevUNvouL6gAq1GsGsWqUawaxebA9T7wqdvsrbGrOOxy8dv9_-C4D0ig9Avs9n-V</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2719477475</pqid></control><display><type>article</type><title>Short-term biological variation of serum glial fibrillary acidic protein</title><source>De Gruyter journals</source><creator>Christensen, Silje Hovden ; Hviid, Claus Vinter Bødker ; Madsen, Anne Tranberg ; Parkner, Tina ; Winther-Larsen, Anne</creator><creatorcontrib>Christensen, Silje Hovden ; Hviid, Claus Vinter Bødker ; Madsen, Anne Tranberg ; Parkner, Tina ; Winther-Larsen, Anne</creatorcontrib><description>Serum glial fibrillary acidic protein (GFAP) is an emerging biomarker for intracerebral diseases and is approved for clinical use in traumatic brain injury. GFAP is also being investigated for several other applications, where the GFAP changes are not always outstanding. It is thus essential for the interpretation of GFAP to distinguish clinical relevant changes from natural occurring biological variation. This study aimed at estimating the biological variation of serum GFAP.Apparently healthy subjects (n=33) had blood sampled for three consecutive days. On the second day, blood was also drawn every third hour from 9 AM to 9 PM. Serum GFAP was measured by Single Molecule Array (Simoa™). Components of biological variation were estimated in a linear mixed-effects model.The overall median GFAP value was 92.5 pg/mL (range 34.4–260.3 pg/mL). The overall within– (CVI) and between-subject variations (CVG) were 9.7 and 39.5%. The reference change value was 36.9% for an increase. No day-to-day variation was observed, however semidiurnal variation was observed with increasing GFAP values between 9 AM and 12 PM (p<0.00001) and decreasing from 12 to 9 PM (p<0.001).Serum GFAP exhibits a relatively low CVI but a considerable CVG and a marked semidiurnal variation. This implies caution on the timing of blood sampling and when interpreting GFAP in relation to reference intervals, especially in conditions where only small GFAP differences are observed.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/cclm-2022-0480</identifier><language>eng</language><publisher>Berlin: De Gruyter</publisher><subject>Biological variation ; Biomarkers ; Blood ; depressive disorder ; Diurnal variations ; Glial fibrillary acidic protein ; Head injuries ; individual ; nervous system diseases ; Proteins ; Traumatic brain injury ; Variation</subject><ispartof>Clinical chemistry and laboratory medicine, 2022-10, Vol.60 (11), p.1813-1819</ispartof><rights>2022 Walter de Gruyter GmbH, Berlin/Boston</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-a41077beb950a9b2222a5810882a1f1b7ca5d5d1afb601197e8bff2e49850df83</citedby><cites>FETCH-LOGICAL-c355t-a41077beb950a9b2222a5810882a1f1b7ca5d5d1afb601197e8bff2e49850df83</cites><orcidid>0000-0001-9146-5943</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2022-0480/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2022-0480/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,66761,68545</link.rule.ids></links><search><creatorcontrib>Christensen, Silje Hovden</creatorcontrib><creatorcontrib>Hviid, Claus Vinter Bødker</creatorcontrib><creatorcontrib>Madsen, Anne Tranberg</creatorcontrib><creatorcontrib>Parkner, Tina</creatorcontrib><creatorcontrib>Winther-Larsen, Anne</creatorcontrib><title>Short-term biological variation of serum glial fibrillary acidic protein</title><title>Clinical chemistry and laboratory medicine</title><description>Serum glial fibrillary acidic protein (GFAP) is an emerging biomarker for intracerebral diseases and is approved for clinical use in traumatic brain injury. GFAP is also being investigated for several other applications, where the GFAP changes are not always outstanding. It is thus essential for the interpretation of GFAP to distinguish clinical relevant changes from natural occurring biological variation. This study aimed at estimating the biological variation of serum GFAP.Apparently healthy subjects (n=33) had blood sampled for three consecutive days. On the second day, blood was also drawn every third hour from 9 AM to 9 PM. Serum GFAP was measured by Single Molecule Array (Simoa™). Components of biological variation were estimated in a linear mixed-effects model.The overall median GFAP value was 92.5 pg/mL (range 34.4–260.3 pg/mL). The overall within– (CVI) and between-subject variations (CVG) were 9.7 and 39.5%. The reference change value was 36.9% for an increase. No day-to-day variation was observed, however semidiurnal variation was observed with increasing GFAP values between 9 AM and 12 PM (p<0.00001) and decreasing from 12 to 9 PM (p<0.001).Serum GFAP exhibits a relatively low CVI but a considerable CVG and a marked semidiurnal variation. This implies caution on the timing of blood sampling and when interpreting GFAP in relation to reference intervals, especially in conditions where only small GFAP differences are observed.</description><subject>Biological variation</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>depressive disorder</subject><subject>Diurnal variations</subject><subject>Glial fibrillary acidic protein</subject><subject>Head injuries</subject><subject>individual</subject><subject>nervous system diseases</subject><subject>Proteins</subject><subject>Traumatic brain injury</subject><subject>Variation</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNptkE1LAzEQhhdRsFavnhe8eEnN5KPJXgQpagXBg3oO2WxSU3abmuwq_fdmrSCIuWQgzzuZeYriHPAMOPArY9oOEUwIwkzig2ICjArEKIXD75qh-ZzAcXGS0hpj4JyJSbF8fguxR72NXVn70IaVN7otP3T0uvdhUwZXJhuHrly1Pj84X0fftjruSm184025jaG3fnNaHDndJnv2c0-L17vbl8USPT7dPyxuHpGhnPdIM8BC1LauONZVTfLRXAKWkmhwUAujecMb0K6eY4BKWFk7RyyrJMeNk3RaXO775n_fB5t61flkbB5pY8OQFBGYgJC0ohm9-IOuwxA3ebpMQcWEYIJnaranTAwpRevUNvouL6gAq1GsGsWqUawaxebA9T7wqdvsrbGrOOxy8dv9_-C4D0ig9Avs9n-V</recordid><startdate>20221026</startdate><enddate>20221026</enddate><creator>Christensen, Silje Hovden</creator><creator>Hviid, Claus Vinter Bødker</creator><creator>Madsen, Anne Tranberg</creator><creator>Parkner, Tina</creator><creator>Winther-Larsen, Anne</creator><general>De Gruyter</general><general>Walter De Gruyter & Company</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9146-5943</orcidid></search><sort><creationdate>20221026</creationdate><title>Short-term biological variation of serum glial fibrillary acidic protein</title><author>Christensen, Silje Hovden ; Hviid, Claus Vinter Bødker ; Madsen, Anne Tranberg ; Parkner, Tina ; Winther-Larsen, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-a41077beb950a9b2222a5810882a1f1b7ca5d5d1afb601197e8bff2e49850df83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biological variation</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>depressive disorder</topic><topic>Diurnal variations</topic><topic>Glial fibrillary acidic protein</topic><topic>Head injuries</topic><topic>individual</topic><topic>nervous system diseases</topic><topic>Proteins</topic><topic>Traumatic brain injury</topic><topic>Variation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christensen, Silje Hovden</creatorcontrib><creatorcontrib>Hviid, Claus Vinter Bødker</creatorcontrib><creatorcontrib>Madsen, Anne Tranberg</creatorcontrib><creatorcontrib>Parkner, Tina</creatorcontrib><creatorcontrib>Winther-Larsen, Anne</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christensen, Silje Hovden</au><au>Hviid, Claus Vinter Bødker</au><au>Madsen, Anne Tranberg</au><au>Parkner, Tina</au><au>Winther-Larsen, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-term biological variation of serum glial fibrillary acidic protein</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><date>2022-10-26</date><risdate>2022</risdate><volume>60</volume><issue>11</issue><spage>1813</spage><epage>1819</epage><pages>1813-1819</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract>Serum glial fibrillary acidic protein (GFAP) is an emerging biomarker for intracerebral diseases and is approved for clinical use in traumatic brain injury. GFAP is also being investigated for several other applications, where the GFAP changes are not always outstanding. It is thus essential for the interpretation of GFAP to distinguish clinical relevant changes from natural occurring biological variation. This study aimed at estimating the biological variation of serum GFAP.Apparently healthy subjects (n=33) had blood sampled for three consecutive days. On the second day, blood was also drawn every third hour from 9 AM to 9 PM. Serum GFAP was measured by Single Molecule Array (Simoa™). Components of biological variation were estimated in a linear mixed-effects model.The overall median GFAP value was 92.5 pg/mL (range 34.4–260.3 pg/mL). The overall within– (CVI) and between-subject variations (CVG) were 9.7 and 39.5%. The reference change value was 36.9% for an increase. No day-to-day variation was observed, however semidiurnal variation was observed with increasing GFAP values between 9 AM and 12 PM (p<0.00001) and decreasing from 12 to 9 PM (p<0.001).Serum GFAP exhibits a relatively low CVI but a considerable CVG and a marked semidiurnal variation. This implies caution on the timing of blood sampling and when interpreting GFAP in relation to reference intervals, especially in conditions where only small GFAP differences are observed.</abstract><cop>Berlin</cop><pub>De Gruyter</pub><doi>10.1515/cclm-2022-0480</doi><tpages>07</tpages><orcidid>https://orcid.org/0000-0001-9146-5943</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1434-6621 |
| ispartof | Clinical chemistry and laboratory medicine, 2022-10, Vol.60 (11), p.1813-1819 |
| issn | 1434-6621 1437-4331 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2702178393 |
| source | De Gruyter journals |
| subjects | Biological variation Biomarkers Blood depressive disorder Diurnal variations Glial fibrillary acidic protein Head injuries individual nervous system diseases Proteins Traumatic brain injury Variation |
| title | Short-term biological variation of serum glial fibrillary acidic protein |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T23%3A57%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Short-term%20biological%20variation%20of%20serum%20glial%20fibrillary%20acidic%20protein&rft.jtitle=Clinical%20chemistry%20and%20laboratory%20medicine&rft.au=Christensen,%20Silje%20Hovden&rft.date=2022-10-26&rft.volume=60&rft.issue=11&rft.spage=1813&rft.epage=1819&rft.pages=1813-1819&rft.issn=1434-6621&rft.eissn=1437-4331&rft_id=info:doi/10.1515/cclm-2022-0480&rft_dat=%3Cproquest_cross%3E2702178393%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2719477475&rft_id=info:pmid/&rfr_iscdi=true |