Tumor mutation burden-assisted risk stratification for papillary thyroid cancer

Tumor mutation burden-assisted risk stratification for papillary thyroid cancer

Purpose Although papillary thyroid cancer (PTC) has a low mortality rate, the rate of recurrence remains relatively high. This study aims to develop a molecular signature to predict the recurrence of PTC. Methods A total of 333 PTC patients’ data from The Cancer Genome Atlas (TCGA) were included. We...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Endocrine 2022-11, Vol.78 (2), p.296-305
Hauptverfasser: Chen, Zhijiang, Wang, Weiran, Xu, Jiajie, Song, Yuntao, Zhu, Honglin, Ma, Tonghui, Ge, Minghua, Guan, Haixia
Format: Artikel
Sprache:eng
Schlagworte:
Diabetes
Endocrinology
Genomes
Genotypes
Humanities and Social Sciences
Internal Medicine
Lymph nodes
Medicine
Medicine & Public Health
Metastases
multidisciplinary
Mutation
Original Article
Papillary thyroid cancer
Patients
Science
Thyroid cancer
Tumors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Purpose Although papillary thyroid cancer (PTC) has a low mortality rate, the rate of recurrence remains relatively high. This study aims to develop a molecular signature to predict the recurrence of PTC. Methods A total of 333 PTC patients’ data from The Cancer Genome Atlas (TCGA) were included. We calculated tumor mutation burden (TMB) and analyzed the mutation status of BRAF and TERT promoter. Results Tumor recurrence occurred in 17 of 263 cases in TMB-L patients versus 14 of 70 cases in TMB-H patients (hazard ratio [HR], 3.55; 95% confidence interval [CI], 1.75–7.21; P  
ISSN:1559-0100
1355-008X
1559-0100
DOI:10.1007/s12020-022-03154-0