Hippo‐YAP signaling activation and cross‐talk with PI3K in oral cancer: A retrospective cohort study

Objectives This study aimed to investigate the clinical and prognostic relevance of the Hippo‐YAP transactivators YAP1 and TAZ in oral squamous cell carcinoma, and their possible relationship with PI3K/mTOR pathway activation. Materials and Methods Immunohistochemical analysis of YAP1, TAZ, PIK3CA (...

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Veröffentlicht in:	Oral diseases 2024-03, Vol.30 (2), p.149-162
Hauptverfasser:	Rodrigo, Juan P., Rodríguez‐Santamarta, Tania, Corte, Daniela, García‐de‐la‐Fuente, Vanessa, Rodríguez‐Torres, Nerea, Lequerica‐Fernández, Paloma, Lorz, Corina, García‐Pedrero, Juana M., Vicente, Juan C.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Cell survival Cytoplasm hippo‐YAP pathway Immunohistochemistry Lymph nodes Medical prognosis Metastases Oral cancer Oral carcinoma Oral squamous cell carcinoma PIK3CA prognosis Squamous cell carcinoma Survival analysis TAZ TOR protein Tumor cells Tumors YAP1 Yes-associated protein
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