Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity

Interferon Regulatory Factor 3 (IRF3) is essential for the production of type I interferon (IFN) during virus infection; however, the mechanism underlying its regulation remains to be elucidated. Here we have identified a novel negative regulatory phosphorylation site on IRF3. In this study, we disc...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2022-09, Vol.150, p.106275-106275, Article 106275
Hauptverfasser:	Cheng, Qi, Yuan, Lijia, Guo, Junhui, Guo, Deyin, Liu, Xueyan, Li, Shun
Format:	Artikel
Sprache:	eng
Schlagworte:	Innate immunity IRF3 Negative regulation phosphorylation site Promoter DNA binding Type I interferon
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