Hexokinase 2: The preferential target of trehalose‐6‐phosphate over hexokinase 1

Cancer‐related metabolic features are in part maintained by hexokinase 2 upregulation, which leads to high levels of glucose‐6‐phosphate (G6P) and is needed to provide energy and biomass to support rapid proliferation. Using a humanized model of the yeast Saccharomyces cerevisiae, we explored how hu...

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Veröffentlicht in:	Journal of cellular biochemistry 2022-11, Vol.123 (11), p.1808-1816
Hauptverfasser:	Magalhães, Rayne S. S., Boechat, Fernanda C., Brasil, Aline A., Neto, José. R. M., Ribeiro, Gabriela D., Paranhos, Luan H., Neves de Souza, Natália, Vieira, Tuane, Outeiro, Tiago F., Neves, Bianca C., Eleutherio, Elis C. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	aerobic glycolysis Biomass energy production Cancer Cell proliferation Cell viability Glucose Glycolysis Hexokinase hexokinase 2 Metabolism Mitochondria Nanotechnology Nuclei (cytology) Regulatory mechanisms (biology) Saccharomyces cerevisiae Stationary phase Sugar Toxicity Trehalose trehalose‐6‐phosphate inhibitor Tumor cells Yeast Yeasts
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