Organochlorine pesticides induce epithelial as well as inflammatory mediators following exposure to human ovarian surface epithelial cells: An in vitro study
Although studies have suggested organochlorine pesticides (OCPs) exposure increased the risk of epithelial ovarian cancer, the mechanisms underlying its potential tumorigenic effects in the human ovary are not well understood. In this study, we investigated the impact of dichlorodiphenyldichloroethy...
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| Veröffentlicht in: | Journal of biochemical and molecular toxicology 2022-11, Vol.36 (11), p.e23191-n/a |
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| container_title | Journal of biochemical and molecular toxicology |
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| creator | Shah, Harendra K. Banerjee, Basu D. Thakur, Gaurav K. Guleria, Kiran |
| description | Although studies have suggested organochlorine pesticides (OCPs) exposure increased the risk of epithelial ovarian cancer, the mechanisms underlying its potential tumorigenic effects in the human ovary are not well understood. In this study, we investigated the impact of dichlorodiphenyldichloroethylene (DDE), endosulfan, and heptachlor exposure on epithelial cadherin (E‐cadherin) and proinflammatory mediators in human ovary surface epithelial (HOSE) cells. We found that DDE, endosulfan, and heptachlor exposure resulted in epithelial differentiation accompanied by upregulation of E‐cadherin expression and overexpression of proinflammatory cytokines (TNFα, IL‐1β, and IL‐6) in HOSE cells. The epithelial differentiation may accelerate HOSE cells to inclusion body formation, a common site for ovarian cancer initiation and persistent exposure to OCPs creates a chronic inflammatory microenvironment that may promote the neoplastic transformation of HOSE cells within the inclusion cyst. |
| doi_str_mv | 10.1002/jbt.23191 |
| format | Article |
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In this study, we investigated the impact of dichlorodiphenyldichloroethylene (DDE), endosulfan, and heptachlor exposure on epithelial cadherin (E‐cadherin) and proinflammatory mediators in human ovary surface epithelial (HOSE) cells. We found that DDE, endosulfan, and heptachlor exposure resulted in epithelial differentiation accompanied by upregulation of E‐cadherin expression and overexpression of proinflammatory cytokines (TNFα, IL‐1β, and IL‐6) in HOSE cells. The epithelial differentiation may accelerate HOSE cells to inclusion body formation, a common site for ovarian cancer initiation and persistent exposure to OCPs creates a chronic inflammatory microenvironment that may promote the neoplastic transformation of HOSE cells within the inclusion cyst.</description><identifier>ISSN: 1095-6670</identifier><identifier>EISSN: 1099-0461</identifier><identifier>DOI: 10.1002/jbt.23191</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Cancer ; Cell differentiation ; Cytokines ; DDE ; Differentiation ; E-cadherin ; Endosulfan ; epithelial cadherin ; Epithelial cells ; epithelial ovarian cancer ; Epithelium ; Exposure ; Heptachlor ; HOSE cells ; inclusion cyst ; Inflammation ; inflammatory cytokines ; Interleukin 6 ; Microenvironments ; Nitrous oxide ; OCPs (DDE, endosulfan, and heptachlor) ; Organic compounds ; Organochlorine compounds ; Organochlorine pesticides ; Ovarian cancer ; Pesticides ; Tumor necrosis factor-α</subject><ispartof>Journal of biochemical and molecular toxicology, 2022-11, Vol.36 (11), p.e23191-n/a</ispartof><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2201-1164a78ba0048aae85a674096d761e07ac649e59bfbb72977d9a6f2c25ed508b3</cites><orcidid>0000-0002-8348-3989</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbt.23191$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbt.23191$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Shah, Harendra K.</creatorcontrib><creatorcontrib>Banerjee, Basu D.</creatorcontrib><creatorcontrib>Thakur, Gaurav K.</creatorcontrib><creatorcontrib>Guleria, Kiran</creatorcontrib><title>Organochlorine pesticides induce epithelial as well as inflammatory mediators following exposure to human ovarian surface epithelial cells: An in vitro study</title><title>Journal of biochemical and molecular toxicology</title><description>Although studies have suggested organochlorine pesticides (OCPs) exposure increased the risk of epithelial ovarian cancer, the mechanisms underlying its potential tumorigenic effects in the human ovary are not well understood. 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The epithelial differentiation may accelerate HOSE cells to inclusion body formation, a common site for ovarian cancer initiation and persistent exposure to OCPs creates a chronic inflammatory microenvironment that may promote the neoplastic transformation of HOSE cells within the inclusion cyst.</description><subject>Cancer</subject><subject>Cell differentiation</subject><subject>Cytokines</subject><subject>DDE</subject><subject>Differentiation</subject><subject>E-cadherin</subject><subject>Endosulfan</subject><subject>epithelial cadherin</subject><subject>Epithelial cells</subject><subject>epithelial ovarian cancer</subject><subject>Epithelium</subject><subject>Exposure</subject><subject>Heptachlor</subject><subject>HOSE cells</subject><subject>inclusion cyst</subject><subject>Inflammation</subject><subject>inflammatory cytokines</subject><subject>Interleukin 6</subject><subject>Microenvironments</subject><subject>Nitrous oxide</subject><subject>OCPs (DDE, endosulfan, and heptachlor)</subject><subject>Organic compounds</subject><subject>Organochlorine compounds</subject><subject>Organochlorine pesticides</subject><subject>Ovarian cancer</subject><subject>Pesticides</subject><subject>Tumor necrosis factor-α</subject><issn>1095-6670</issn><issn>1099-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u2zAQhIWiBZqmOeQNCOTSHpQsaYk0e0uD_BUBfHHPwkpaxTQoUiElO36Yvmtou5cU6GkGi28Hi50sO-dwyQHE1boeL8WMa_4hO-GgdQ6F5B8PvsylVPA5-xLjGgBKrcqT7M8iPKPzzcr6YByxgeJoGtNSZMa1U0OMBjOuyBq0DCPbkj2ocZ3FvsfRhx3rqTV7F1nnrfVb454ZvQ4-ToHY6Nlq6tExv8FgkqZph--Dm5Qaf7Brl3LZxozBszhO7e5r9qlDG-nsr55mv-9ulzcP-dPi_vHm-ilvhACecy4LVPMaAYo5Is1LlKoALVslOYHCRhaaSl13da2EVqrVKDvRiJLaEub17DT7dswdgn-Z0guq3sT9UejIT7ESCkAWQstZQi_-Qdd-Ci5dl6iZBMVFWSTq-5Fqgo8xUFcNwfQYdhWHal9UlYqqDkUl9urIbo2l3f_B6tfP5XHjDdx9l90</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Shah, Harendra K.</creator><creator>Banerjee, Basu D.</creator><creator>Thakur, Gaurav K.</creator><creator>Guleria, Kiran</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8348-3989</orcidid></search><sort><creationdate>202211</creationdate><title>Organochlorine pesticides induce epithelial as well as inflammatory mediators following exposure to human ovarian surface epithelial cells: An in vitro study</title><author>Shah, Harendra K. ; Banerjee, Basu D. ; Thakur, Gaurav K. ; Guleria, Kiran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2201-1164a78ba0048aae85a674096d761e07ac649e59bfbb72977d9a6f2c25ed508b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cancer</topic><topic>Cell differentiation</topic><topic>Cytokines</topic><topic>DDE</topic><topic>Differentiation</topic><topic>E-cadherin</topic><topic>Endosulfan</topic><topic>epithelial cadherin</topic><topic>Epithelial cells</topic><topic>epithelial ovarian cancer</topic><topic>Epithelium</topic><topic>Exposure</topic><topic>Heptachlor</topic><topic>HOSE cells</topic><topic>inclusion cyst</topic><topic>Inflammation</topic><topic>inflammatory cytokines</topic><topic>Interleukin 6</topic><topic>Microenvironments</topic><topic>Nitrous oxide</topic><topic>OCPs (DDE, endosulfan, and heptachlor)</topic><topic>Organic compounds</topic><topic>Organochlorine compounds</topic><topic>Organochlorine pesticides</topic><topic>Ovarian cancer</topic><topic>Pesticides</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shah, Harendra K.</creatorcontrib><creatorcontrib>Banerjee, Basu D.</creatorcontrib><creatorcontrib>Thakur, Gaurav K.</creatorcontrib><creatorcontrib>Guleria, Kiran</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemical and molecular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shah, Harendra K.</au><au>Banerjee, Basu D.</au><au>Thakur, Gaurav K.</au><au>Guleria, Kiran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Organochlorine pesticides induce epithelial as well as inflammatory mediators following exposure to human ovarian surface epithelial cells: An in vitro study</atitle><jtitle>Journal of biochemical and molecular toxicology</jtitle><date>2022-11</date><risdate>2022</risdate><volume>36</volume><issue>11</issue><spage>e23191</spage><epage>n/a</epage><pages>e23191-n/a</pages><issn>1095-6670</issn><eissn>1099-0461</eissn><abstract>Although studies have suggested organochlorine pesticides (OCPs) exposure increased the risk of epithelial ovarian cancer, the mechanisms underlying its potential tumorigenic effects in the human ovary are not well understood. 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| subjects | Cancer Cell differentiation Cytokines DDE Differentiation E-cadherin Endosulfan epithelial cadherin Epithelial cells epithelial ovarian cancer Epithelium Exposure Heptachlor HOSE cells inclusion cyst Inflammation inflammatory cytokines Interleukin 6 Microenvironments Nitrous oxide OCPs (DDE, endosulfan, and heptachlor) Organic compounds Organochlorine compounds Organochlorine pesticides Ovarian cancer Pesticides Tumor necrosis factor-α |
| title | Organochlorine pesticides induce epithelial as well as inflammatory mediators following exposure to human ovarian surface epithelial cells: An in vitro study |
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