Early-onset of social communication and locomotion activity in F2 pups of a valproic acid-induced mouse model of autism

•The emission rate was significantly low in VPA pups of F2 generation.•The locomotive activity with or without littermates was altered in VPA pups of F2 generations.•Social deficit and impaired locomotion are inherited by the subsequent generation and were apparent as early as postnatal day 5. Autis...

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Veröffentlicht in:	Neuroscience letters 2022-09, Vol.788, p.136827-136827, Article 136827
Hauptverfasser:	Tsuji, Chiharu, Furuhara, Kazumi, Mizutani, Ryuko, Minami, Kana, Fu, Pinyue, Zhong, Jing, Higashida, Haruhiro, Yokoyama, Shigeru, Tsuji, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormal locomotion Autism spectrum disorder Epigenetics Transgeneration and intergenerational inheritance Utrasonic vocalizations Valproic acid
Online-Zugang:	Volltext
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