A hypothesis concerning the role of PPAR family on cardiac energetics in Adriamycin‐induced cardiomyopathy

Adriamycin is an effective anti‐neoplastic drug against a variety of cancer types. However, the drug causes adverse side effects in a number of organ systems. Cardiomyopathy is one of the life‐threatening side effects of Adriamycin. In the current work, we have derived a hypothesis with possible inv...

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Veröffentlicht in:	Journal of applied toxicology 2022-12, Vol.42 (12), p.1910-1920
Hauptverfasser:	Mohan, Uma Priya, PB, Tirupathi Pichiah, Kunjiappan, Selvaraj, Arunachalam, Sankarganesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adriamycin Binding sites cardiac energetics Cardiomyocytes Cardiomyopathy cardiotoxicity Electron transport Electron transport chain Fatty acids Heme Homeostasis Hypotheses Iron iron homeostasis Krebs cycle Membrane potential Mitochondria mitochondrial dysfunction Molecular docking Oxidation Oxidative stress Oxygenase Peroxisome proliferator-activated receptors PPAR family Side effects Substrates Succinate dehydrogenase Sulfur Tricarboxylic acid cycle
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