Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents

Microtubules (MTs) are dynamic filaments of the cytoskeleton, which are formed by the polymerization of their building block tubulin. Perturbation of MT dynamics by MT-targeting agents (MTAs) leads to cell cycle arrest or cell death, a strategy that is pursued in chemotherapy. We recently performed...

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Veröffentlicht in:	European journal of medicinal chemistry 2022-11, Vol.241, p.114614-114614, Article 114614
Hauptverfasser:	de la Roche, Noelia Montel, Mühlethaler, Tobias, Di Martino, Rita Maria Concetta, Ortega, Jose Antonio, Gioia, Dario, Roy, Bibhas, Prota, Andrea E., Steinmetz, Michel O., Cavalli, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Colchicine-binding site Fragment growing Microtubule-destabilizing agent Rational drug design
Online-Zugang:	Volltext
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