Anti-inflammatory effects of siponimod on astrocytes

Siponimod, which is approved to treat active secondary progressive multiple sclerosis, acts as a functional antagonist of sphingosine-1-phosphate (S1P) receptor 1 (S1P1) and an agonist of S1P5. S1P1 antagonization, which inhibits lymphocyte egress from lymphoid tissues and subsequent infiltration in...

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Veröffentlicht in:	Neuroscience research 2022-11, Vol.184, p.38-46
Hauptverfasser:	Ogasawara, Akihiro, Takeuchi, Hideyuki, Komiya, Hiroyasu, Ogawa, Yuki, Nishimura, Koki, Kubota, Shun, Hashiguchi, Shunta, Takahashi, Keita, Kunii, Misako, Tanaka, Kenichi, Tada, Mikiko, Doi, Hiroshi, Tanaka, Fumiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocyte Cytokine Histone deacetylase Nuclear factor kappa B Siponimod Sphingosine-1-phosphate Sphingosine-1-phosphate receptor 1
Online-Zugang:	Volltext
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