Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis

The aim of this study is to evaluate the efficacy and safety of coenzyme Q10 supplementation in the treatment of polycystic ovary syndrome (PCOS). We first searched PubMed, Wanfang Data, CNKI, Embase, ClinicalTrial.gov, and other databases. The retrieval time from the establishment of the database t...

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Veröffentlicht in:	Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2023-04, Vol.30 (4), p.1033-1048
Hauptverfasser:	Zhang, Tianqing, He, Qi, Xiu, Hao, Zhang, ZiZhu, Liu, Yao, Chen, Zhenrong, Hu, Hengjing
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholesterol, LDL Dietary Supplements - adverse effects Embryology Female Follicle Stimulating Hormone Gonadal Steroid Hormones Humans Insulin Resistance Lipids Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Polycystic Ovary Syndrome - drug therapy Reproductive Medicine Review Testosterone - therapeutic use
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Zusammenfassung:	The aim of this study is to evaluate the efficacy and safety of coenzyme Q10 supplementation in the treatment of polycystic ovary syndrome (PCOS). We first searched PubMed, Wanfang Data, CNKI, Embase, ClinicalTrial.gov, and other databases. The retrieval time from the establishment of the database to January 2021. We collected relevant randomized controlled trials (RCTs) about coenzyme Q10 in the treatment of PCOS. Risk of bias assessment and meta-analysis of RCTs were performed using RevMan 5.0 software. This systematic review and meta-analysis include a total of 9 RCTs involving 1021 patients. The results show that the addition of coenzyme Q10 may improve insulin resistance (HOMA-IR (WMD − 0.67 [− 0.87, − 0.48], P
ISSN:	1933-7191 1933-7205
DOI:	10.1007/s43032-022-01038-2