An assay procedure to investigate the transformation of toxic heme into inert hemozoin via plasmodial heme detoxification protein

Most antimalarial therapeutics, including chloroquine and artemisinin, induce free heme-mediated toxicity in Plasmodium. This cytotoxic heme is produced as a by-product during the large-scale digestion of host hemoglobin. Conversion of this host-derived heme into inert crystalline hemozoin is the on...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochimica et biophysica acta. Proteins and proteomics 2022-09, Vol.1870 (9), p.140832-140832, Article 140832
Hauptverfasser:	Singh, Rahul, Makde, Ravindra D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Avrami HDP Heme Hemozoin Plasmodium Pyridine- hemochrome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!