Two‐dimensional chromatography in screening of bioactive components from natural products
Introduction Screening and analysis of bioactive components from natural products is a fundamental part of new drug development and innovation. Two‐dimensional (2D) chromatography has been demonstrated to be an effective method for screening and preparation of specific bioactive components from comp...
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| Veröffentlicht in: | Phytochemical analysis 2022-12, Vol.33 (8), p.1161-1176 |
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| container_title | Phytochemical analysis |
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| creator | Xiang, Haiping Xu, Ping Qiu, Huiyun Wen, Weiyi Zhang, Ailian Tong, Shengqiang |
| description | Introduction
Screening and analysis of bioactive components from natural products is a fundamental part of new drug development and innovation. Two‐dimensional (2D) chromatography has been demonstrated to be an effective method for screening and preparation of specific bioactive components from complex natural products.
Objective
To collect details of application of 2D chromatography in screening of natural product bioactive components and to outline the research progress of different separation mechanisms and strategies.
Methodology
Three screening strategies based on 2D chromatography are reviewed, including traditional separation‐based screening, bioactivity‐guided screening and affinity chromatography‐based screening. Meanwhile, in order to cover these aspects, selections of different separation mechanisms and modes are also presented.
Results
Compared with traditional one‐dimensional (1D) chromatography, 2D chromatography has unique advantages in terms of peak capacity and resolution, and it is more effective for screening and identifying bioactive components of complex natural products.
Conclusion
Screening of natural bioactive components using 2D chromatography helps separation and analysis of complex samples with greater targeting and relevance, which is very important for development of innovative drug leads.
Screening and analysis of bioactive components from natural products is a fundamental part of new drug development and innovation. Compared with traditional one‐dimensional (1D) chromatography, two‐dimensional (2D) chromatography has unique advantages in terms of peak capacity and resolution, and it is more effective for screening and identifying bioactive components of complex natural products. Three screening strategies based on 2D chromatography are reviewed; meanwhile, in order to cover these aspects, selections of different separation mechanisms and modes are also presented. |
| doi_str_mv | 10.1002/pca.3168 |
| format | Article |
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Screening and analysis of bioactive components from natural products is a fundamental part of new drug development and innovation. Two‐dimensional (2D) chromatography has been demonstrated to be an effective method for screening and preparation of specific bioactive components from complex natural products.
Objective
To collect details of application of 2D chromatography in screening of natural product bioactive components and to outline the research progress of different separation mechanisms and strategies.
Methodology
Three screening strategies based on 2D chromatography are reviewed, including traditional separation‐based screening, bioactivity‐guided screening and affinity chromatography‐based screening. Meanwhile, in order to cover these aspects, selections of different separation mechanisms and modes are also presented.
Results
Compared with traditional one‐dimensional (1D) chromatography, 2D chromatography has unique advantages in terms of peak capacity and resolution, and it is more effective for screening and identifying bioactive components of complex natural products.
Conclusion
Screening of natural bioactive components using 2D chromatography helps separation and analysis of complex samples with greater targeting and relevance, which is very important for development of innovative drug leads.
Screening and analysis of bioactive components from natural products is a fundamental part of new drug development and innovation. Compared with traditional one‐dimensional (1D) chromatography, two‐dimensional (2D) chromatography has unique advantages in terms of peak capacity and resolution, and it is more effective for screening and identifying bioactive components of complex natural products. Three screening strategies based on 2D chromatography are reviewed; meanwhile, in order to cover these aspects, selections of different separation mechanisms and modes are also presented.</description><identifier>ISSN: 0958-0344</identifier><identifier>EISSN: 1099-1565</identifier><identifier>DOI: 10.1002/pca.3168</identifier><language>eng</language><publisher>Bognor Regis: Wiley Subscription Services, Inc</publisher><subject>2D chromatography ; Affinity chromatography ; bioactive components ; Biological activity ; Chromatography ; Drug development ; Natural products ; Screening ; Separation ; Two dimensional analysis</subject><ispartof>Phytochemical analysis, 2022-12, Vol.33 (8), p.1161-1176</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3268-1bfeec18a9273a0e28cf2ea29520452bad931d75d7efa808838c226506ddc0013</citedby><cites>FETCH-LOGICAL-c3268-1bfeec18a9273a0e28cf2ea29520452bad931d75d7efa808838c226506ddc0013</cites><orcidid>0000-0001-5867-7354</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpca.3168$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpca.3168$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids></links><search><creatorcontrib>Xiang, Haiping</creatorcontrib><creatorcontrib>Xu, Ping</creatorcontrib><creatorcontrib>Qiu, Huiyun</creatorcontrib><creatorcontrib>Wen, Weiyi</creatorcontrib><creatorcontrib>Zhang, Ailian</creatorcontrib><creatorcontrib>Tong, Shengqiang</creatorcontrib><title>Two‐dimensional chromatography in screening of bioactive components from natural products</title><title>Phytochemical analysis</title><description>Introduction
Screening and analysis of bioactive components from natural products is a fundamental part of new drug development and innovation. Two‐dimensional (2D) chromatography has been demonstrated to be an effective method for screening and preparation of specific bioactive components from complex natural products.
Objective
To collect details of application of 2D chromatography in screening of natural product bioactive components and to outline the research progress of different separation mechanisms and strategies.
Methodology
Three screening strategies based on 2D chromatography are reviewed, including traditional separation‐based screening, bioactivity‐guided screening and affinity chromatography‐based screening. Meanwhile, in order to cover these aspects, selections of different separation mechanisms and modes are also presented.
Results
Compared with traditional one‐dimensional (1D) chromatography, 2D chromatography has unique advantages in terms of peak capacity and resolution, and it is more effective for screening and identifying bioactive components of complex natural products.
Conclusion
Screening of natural bioactive components using 2D chromatography helps separation and analysis of complex samples with greater targeting and relevance, which is very important for development of innovative drug leads.
Screening and analysis of bioactive components from natural products is a fundamental part of new drug development and innovation. Compared with traditional one‐dimensional (1D) chromatography, two‐dimensional (2D) chromatography has unique advantages in terms of peak capacity and resolution, and it is more effective for screening and identifying bioactive components of complex natural products. Three screening strategies based on 2D chromatography are reviewed; meanwhile, in order to cover these aspects, selections of different separation mechanisms and modes are also presented.</description><subject>2D chromatography</subject><subject>Affinity chromatography</subject><subject>bioactive components</subject><subject>Biological activity</subject><subject>Chromatography</subject><subject>Drug development</subject><subject>Natural products</subject><subject>Screening</subject><subject>Separation</subject><subject>Two dimensional analysis</subject><issn>0958-0344</issn><issn>1099-1565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKAzEUhoMoWKvgIwTcuJmayySTWZbiDQq6qCsXIc1k2pSZZExmLN35CD6jT2KqgiC4Oovznf_wfwCcYzTBCJGrTqsJxVwcgBFGZZlhxtkhGKGSiQzRPD8GJzFuEEq7ko_A82LrP97eK9saF613qoF6HXyrer8KqlvvoHUw6mCMs24FfQ2X1ivd21cDtW8774zrI6zTCXSqH0IK6IKvBt3HU3BUqyaas585Bk8314vZXTZ_uL2fTeeZpoSLDC9rYzQWqiQFVcgQoWtiFCkZQTkjS1WVFFcFqwpTK4GEoEITwhniVaURwnQMLr9z0-OXwcRetjZq0zTKGT9ESXjqynguioRe_EE3fgipdaKKnHOKS0R_A3XwMQZTyy7YVoWdxEjuLctkWe4tJzT7Rre2Mbt_Ofk4m37xn6B7f40</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Xiang, Haiping</creator><creator>Xu, Ping</creator><creator>Qiu, Huiyun</creator><creator>Wen, Weiyi</creator><creator>Zhang, Ailian</creator><creator>Tong, Shengqiang</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5867-7354</orcidid></search><sort><creationdate>202212</creationdate><title>Two‐dimensional chromatography in screening of bioactive components from natural products</title><author>Xiang, Haiping ; Xu, Ping ; Qiu, Huiyun ; Wen, Weiyi ; Zhang, Ailian ; Tong, Shengqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3268-1bfeec18a9273a0e28cf2ea29520452bad931d75d7efa808838c226506ddc0013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>2D chromatography</topic><topic>Affinity chromatography</topic><topic>bioactive components</topic><topic>Biological activity</topic><topic>Chromatography</topic><topic>Drug development</topic><topic>Natural products</topic><topic>Screening</topic><topic>Separation</topic><topic>Two dimensional analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiang, Haiping</creatorcontrib><creatorcontrib>Xu, Ping</creatorcontrib><creatorcontrib>Qiu, Huiyun</creatorcontrib><creatorcontrib>Wen, Weiyi</creatorcontrib><creatorcontrib>Zhang, Ailian</creatorcontrib><creatorcontrib>Tong, Shengqiang</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiang, Haiping</au><au>Xu, Ping</au><au>Qiu, Huiyun</au><au>Wen, Weiyi</au><au>Zhang, Ailian</au><au>Tong, Shengqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two‐dimensional chromatography in screening of bioactive components from natural products</atitle><jtitle>Phytochemical analysis</jtitle><date>2022-12</date><risdate>2022</risdate><volume>33</volume><issue>8</issue><spage>1161</spage><epage>1176</epage><pages>1161-1176</pages><issn>0958-0344</issn><eissn>1099-1565</eissn><abstract>Introduction
Screening and analysis of bioactive components from natural products is a fundamental part of new drug development and innovation. Two‐dimensional (2D) chromatography has been demonstrated to be an effective method for screening and preparation of specific bioactive components from complex natural products.
Objective
To collect details of application of 2D chromatography in screening of natural product bioactive components and to outline the research progress of different separation mechanisms and strategies.
Methodology
Three screening strategies based on 2D chromatography are reviewed, including traditional separation‐based screening, bioactivity‐guided screening and affinity chromatography‐based screening. Meanwhile, in order to cover these aspects, selections of different separation mechanisms and modes are also presented.
Results
Compared with traditional one‐dimensional (1D) chromatography, 2D chromatography has unique advantages in terms of peak capacity and resolution, and it is more effective for screening and identifying bioactive components of complex natural products.
Conclusion
Screening of natural bioactive components using 2D chromatography helps separation and analysis of complex samples with greater targeting and relevance, which is very important for development of innovative drug leads.
Screening and analysis of bioactive components from natural products is a fundamental part of new drug development and innovation. Compared with traditional one‐dimensional (1D) chromatography, two‐dimensional (2D) chromatography has unique advantages in terms of peak capacity and resolution, and it is more effective for screening and identifying bioactive components of complex natural products. Three screening strategies based on 2D chromatography are reviewed; meanwhile, in order to cover these aspects, selections of different separation mechanisms and modes are also presented.</abstract><cop>Bognor Regis</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/pca.3168</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-5867-7354</orcidid></addata></record> |
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| source | Wiley Online Library All Journals |
| subjects | 2D chromatography Affinity chromatography bioactive components Biological activity Chromatography Drug development Natural products Screening Separation Two dimensional analysis |
| title | Two‐dimensional chromatography in screening of bioactive components from natural products |
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