Effect of bioactive glasses used as dentin desensitizers on the dentin-pulp complex in rats
Bioactive glasses have been recommended for the occlusion of dentinal tubules in treating cervical dentin hypersensitivity. This study evaluates an in vivo model of dentin exposure, and tests the efficacy of bioglass treatments. Thirty male Wistar rats received gingival recession surgery on the uppe...
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| Veröffentlicht in: | Dental Materials Journal 2022/11/25, Vol.41(6), pp.874-881 |
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| creator | DALMOLIN, Ana Cláudia ACEVEDO, Luisa Fernanda Alegria CAMPOS, Letícia Antonelo DECHANDT, Iolanda Cristina Justus SERBENA, Francisco Carlos ZANOTTO, Edgar Dutra POCHAPSKI, Márcia Thaís ARRAIS, César Augusto Galvão CAMPAGNOLI, Eduardo Bauml SANTOS, Fábio André dos |
| description | Bioactive glasses have been recommended for the occlusion of dentinal tubules in treating cervical dentin hypersensitivity. This study evaluates an in vivo model of dentin exposure, and tests the efficacy of bioglass treatments. Thirty male Wistar rats received gingival recession surgery on the upper left first molar. The treatments were applied over the surface of the exposed dentin every 4 days for 28 days. The groups were as follows: Naive; Gingival recession; Cavity varnish; Biosilicate®; Strontium bioglass; and Potassium bioglass. Changes in the dentin-pulp complex, and the presence of substance P, were evaluated through hematoxylin-eosin and immunohistochemical staining. The groups had similar results. Teeth with exposed dentinal tubules in rats showed a typical pattern in the dentin-pulp complex and immunotracing for substance P. The materials did not cause pulp damage. The effects of gingival recession and open dentinal tubules on pulp tissue require further clarification. |
| doi_str_mv | 10.4012/dmj.2022-017 |
| format | Article |
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This study evaluates an in vivo model of dentin exposure, and tests the efficacy of bioglass treatments. Thirty male Wistar rats received gingival recession surgery on the upper left first molar. The treatments were applied over the surface of the exposed dentin every 4 days for 28 days. The groups were as follows: Naive; Gingival recession; Cavity varnish; Biosilicate®; Strontium bioglass; and Potassium bioglass. Changes in the dentin-pulp complex, and the presence of substance P, were evaluated through hematoxylin-eosin and immunohistochemical staining. The groups had similar results. Teeth with exposed dentinal tubules in rats showed a typical pattern in the dentin-pulp complex and immunotracing for substance P. The materials did not cause pulp damage. The effects of gingival recession and open dentinal tubules on pulp tissue require further clarification.</description><identifier>ISSN: 0287-4547</identifier><identifier>EISSN: 1881-1361</identifier><identifier>DOI: 10.4012/dmj.2022-017</identifier><language>eng</language><publisher>Tokyo: The Japanese Society for Dental Materials and Devices</publisher><subject>Animal models ; Biocompatible materials ; Bioglass ; Biological activity ; Dental pulp ; Dentin ; Exposure ; Gingiva ; Gingival recession ; Hypersensitivity ; In vivo methods and tests ; Inflammation ; Occlusion ; Potassium ; Recession ; Silicic acid ; Strontium ; Substance P ; Teeth ; Tubules</subject><ispartof>Dental Materials Journal, 2022/11/25, Vol.41(6), pp.874-881</ispartof><rights>2022 The Japanese Society for Dental Materials and Devices</rights><rights>Copyright Japan Science and Technology Agency 2022</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c632t-ed4d7ba2013e79a25332ea24604d4c9ddd4c2d6ec511fbb26ca8e7e5f546d4573</citedby><cites>FETCH-LOGICAL-c632t-ed4d7ba2013e79a25332ea24604d4c9ddd4c2d6ec511fbb26ca8e7e5f546d4573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids></links><search><creatorcontrib>DALMOLIN, Ana Cláudia</creatorcontrib><creatorcontrib>ACEVEDO, Luisa Fernanda Alegria</creatorcontrib><creatorcontrib>CAMPOS, Letícia Antonelo</creatorcontrib><creatorcontrib>DECHANDT, Iolanda Cristina Justus</creatorcontrib><creatorcontrib>SERBENA, Francisco Carlos</creatorcontrib><creatorcontrib>ZANOTTO, Edgar Dutra</creatorcontrib><creatorcontrib>POCHAPSKI, Márcia Thaís</creatorcontrib><creatorcontrib>ARRAIS, César Augusto Galvão</creatorcontrib><creatorcontrib>CAMPAGNOLI, Eduardo Bauml</creatorcontrib><creatorcontrib>SANTOS, Fábio André dos</creatorcontrib><creatorcontrib>State University of Ponta Grossa (UEPG</creatorcontrib><creatorcontrib>Physics Department</creatorcontrib><creatorcontrib>Federal University of Sao Carlos</creatorcontrib><creatorcontrib>Dentistry Department</creatorcontrib><creatorcontrib>Department of Materials Engineering</creatorcontrib><title>Effect of bioactive glasses used as dentin desensitizers on the dentin-pulp complex in rats</title><title>Dental Materials Journal</title><addtitle>Dent. Mater. J.</addtitle><description>Bioactive glasses have been recommended for the occlusion of dentinal tubules in treating cervical dentin hypersensitivity. This study evaluates an in vivo model of dentin exposure, and tests the efficacy of bioglass treatments. Thirty male Wistar rats received gingival recession surgery on the upper left first molar. The treatments were applied over the surface of the exposed dentin every 4 days for 28 days. The groups were as follows: Naive; Gingival recession; Cavity varnish; Biosilicate®; Strontium bioglass; and Potassium bioglass. Changes in the dentin-pulp complex, and the presence of substance P, were evaluated through hematoxylin-eosin and immunohistochemical staining. The groups had similar results. Teeth with exposed dentinal tubules in rats showed a typical pattern in the dentin-pulp complex and immunotracing for substance P. The materials did not cause pulp damage. The effects of gingival recession and open dentinal tubules on pulp tissue require further clarification.</description><subject>Animal models</subject><subject>Biocompatible materials</subject><subject>Bioglass</subject><subject>Biological activity</subject><subject>Dental pulp</subject><subject>Dentin</subject><subject>Exposure</subject><subject>Gingiva</subject><subject>Gingival recession</subject><subject>Hypersensitivity</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Occlusion</subject><subject>Potassium</subject><subject>Recession</subject><subject>Silicic acid</subject><subject>Strontium</subject><subject>Substance P</subject><subject>Teeth</subject><subject>Tubules</subject><issn>0287-4547</issn><issn>1881-1361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kT1vFDEQhi0EEkeg4wdYoqFgg7_W9pYQhYAUKU1SpbB89mzik3e92F6U8OvxceGQKGhminnmnZl3EHpLyakglH300-6UEcY6QtUztKFa045ySZ-jDWFadaIX6iV6VcqOEDFIrTfo9nwcwVWcRrwNyboafgC-i7YUKHgt4LEt2MNcw9xSgbmEGn5CLjjNuN7DU61b1rhgl6YlwgNubLa1vEYvRhsLvHnKJ-jmy_n12dfu8uri29mny85JzmoHXni1tYxQDmqwrOecgWVCEuGFG7xvkXkJrqd03G6ZdFaDgn7shfSiV_wEvT_oLjl9X6FUM4XiIEY7Q1qLYXIYhl626xv67h90l9Y8t-0MU0pyIbTk_6eEau42axv14UC5nErJMJolh8nmR0OJ2f_DtH-Y_T9M62j4xQGfwAdnY5pjmOGvsn8kzctjBxGUyNZIDdFKtKCpoJQMYr_e54PSrlR7B8exNtfgIvweK6iR-_Bn_LHo7m02MPNfTk6rBA</recordid><startdate>20221125</startdate><enddate>20221125</enddate><creator>DALMOLIN, Ana Cláudia</creator><creator>ACEVEDO, Luisa Fernanda Alegria</creator><creator>CAMPOS, Letícia Antonelo</creator><creator>DECHANDT, Iolanda Cristina Justus</creator><creator>SERBENA, Francisco Carlos</creator><creator>ZANOTTO, Edgar Dutra</creator><creator>POCHAPSKI, Márcia Thaís</creator><creator>ARRAIS, César Augusto Galvão</creator><creator>CAMPAGNOLI, Eduardo Bauml</creator><creator>SANTOS, Fábio André dos</creator><general>The Japanese Society for Dental Materials and Devices</general><general>Japanese Society for Dental Materials and Devices</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20221125</creationdate><title>Effect of bioactive glasses used as dentin desensitizers on the dentin-pulp complex in rats</title><author>DALMOLIN, Ana Cláudia ; ACEVEDO, Luisa Fernanda Alegria ; CAMPOS, Letícia Antonelo ; DECHANDT, Iolanda Cristina Justus ; SERBENA, Francisco Carlos ; ZANOTTO, Edgar Dutra ; POCHAPSKI, Márcia Thaís ; ARRAIS, César Augusto Galvão ; CAMPAGNOLI, Eduardo Bauml ; SANTOS, Fábio André dos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c632t-ed4d7ba2013e79a25332ea24604d4c9ddd4c2d6ec511fbb26ca8e7e5f546d4573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animal models</topic><topic>Biocompatible materials</topic><topic>Bioglass</topic><topic>Biological activity</topic><topic>Dental pulp</topic><topic>Dentin</topic><topic>Exposure</topic><topic>Gingiva</topic><topic>Gingival recession</topic><topic>Hypersensitivity</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>Occlusion</topic><topic>Potassium</topic><topic>Recession</topic><topic>Silicic acid</topic><topic>Strontium</topic><topic>Substance P</topic><topic>Teeth</topic><topic>Tubules</topic><toplevel>online_resources</toplevel><creatorcontrib>DALMOLIN, Ana Cláudia</creatorcontrib><creatorcontrib>ACEVEDO, Luisa Fernanda Alegria</creatorcontrib><creatorcontrib>CAMPOS, Letícia Antonelo</creatorcontrib><creatorcontrib>DECHANDT, Iolanda Cristina Justus</creatorcontrib><creatorcontrib>SERBENA, Francisco Carlos</creatorcontrib><creatorcontrib>ZANOTTO, Edgar Dutra</creatorcontrib><creatorcontrib>POCHAPSKI, Márcia Thaís</creatorcontrib><creatorcontrib>ARRAIS, César Augusto Galvão</creatorcontrib><creatorcontrib>CAMPAGNOLI, Eduardo Bauml</creatorcontrib><creatorcontrib>SANTOS, Fábio André dos</creatorcontrib><creatorcontrib>State University of Ponta Grossa (UEPG</creatorcontrib><creatorcontrib>Physics Department</creatorcontrib><creatorcontrib>Federal University of Sao Carlos</creatorcontrib><creatorcontrib>Dentistry Department</creatorcontrib><creatorcontrib>Department of Materials Engineering</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Dental Materials Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DALMOLIN, Ana Cláudia</au><au>ACEVEDO, Luisa Fernanda Alegria</au><au>CAMPOS, Letícia Antonelo</au><au>DECHANDT, Iolanda Cristina Justus</au><au>SERBENA, Francisco Carlos</au><au>ZANOTTO, Edgar Dutra</au><au>POCHAPSKI, Márcia Thaís</au><au>ARRAIS, César Augusto Galvão</au><au>CAMPAGNOLI, Eduardo Bauml</au><au>SANTOS, Fábio André dos</au><aucorp>State University of Ponta Grossa (UEPG</aucorp><aucorp>Physics Department</aucorp><aucorp>Federal University of Sao Carlos</aucorp><aucorp>Dentistry Department</aucorp><aucorp>Department of Materials Engineering</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of bioactive glasses used as dentin desensitizers on the dentin-pulp complex in rats</atitle><jtitle>Dental Materials Journal</jtitle><addtitle>Dent. Mater. J.</addtitle><date>2022-11-25</date><risdate>2022</risdate><volume>41</volume><issue>6</issue><spage>874</spage><epage>881</epage><pages>874-881</pages><artnum>2022-017</artnum><issn>0287-4547</issn><eissn>1881-1361</eissn><abstract>Bioactive glasses have been recommended for the occlusion of dentinal tubules in treating cervical dentin hypersensitivity. This study evaluates an in vivo model of dentin exposure, and tests the efficacy of bioglass treatments. Thirty male Wistar rats received gingival recession surgery on the upper left first molar. The treatments were applied over the surface of the exposed dentin every 4 days for 28 days. The groups were as follows: Naive; Gingival recession; Cavity varnish; Biosilicate®; Strontium bioglass; and Potassium bioglass. Changes in the dentin-pulp complex, and the presence of substance P, were evaluated through hematoxylin-eosin and immunohistochemical staining. The groups had similar results. Teeth with exposed dentinal tubules in rats showed a typical pattern in the dentin-pulp complex and immunotracing for substance P. The materials did not cause pulp damage. The effects of gingival recession and open dentinal tubules on pulp tissue require further clarification.</abstract><cop>Tokyo</cop><pub>The Japanese Society for Dental Materials and Devices</pub><doi>10.4012/dmj.2022-017</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animal models Biocompatible materials Bioglass Biological activity Dental pulp Dentin Exposure Gingiva Gingival recession Hypersensitivity In vivo methods and tests Inflammation Occlusion Potassium Recession Silicic acid Strontium Substance P Teeth Tubules |
| title | Effect of bioactive glasses used as dentin desensitizers on the dentin-pulp complex in rats |
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