Antiangiogenic Molecules Suppressed Meningioma-Induced Neovascularization: A Corneal Angiogenesis Study

Antiangiogenic Molecules Suppressed Meningioma-Induced Neovascularization: A Corneal Angiogenesis Study

AIMTo investigate the angiogenic effects of bevacizumab and imatinib on different meningioma tissue grades. MATERIAL AND METHODSIn this study, in silico analysis of angiogenesis-related gene expression was carried out using previously reported datasets. Messenger ribonucleic acid expressions of VEGF...

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Veröffentlicht in:Turkish neurosurgery 2022-01, Vol.32 (5), p.786-792
Hauptverfasser: Tatarli, Necati, Ceylan, Davut, Oksal, M Deniz, Avsar, Timucin, Kilic, Turker
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container_end_page 792
container_issue 5
container_start_page 786
container_title Turkish neurosurgery
container_volume 32
creator Tatarli, Necati
Ceylan, Davut
Oksal, M Deniz
Avsar, Timucin
Kilic, Turker
description AIMTo investigate the angiogenic effects of bevacizumab and imatinib on different meningioma tissue grades. MATERIAL AND METHODSIn this study, in silico analysis of angiogenesis-related gene expression was carried out using previously reported datasets. Messenger ribonucleic acid expressions of VEGFA, VEGFB, PDGFRA, and PDGFRB genes were obtained from two different meningioma transcriptome datasets. The effect of antiangiogenic drugs, bevacizumab and imatinib, on meningiomainduced vascularization was assessed by using rat corneal angiogenesis assay (CAA). RESULTSBevacizumab and imatinib both significantly reduced meningioma-induced neovascularization in the CAA model. CONCLUSIONThe angiogenic characteristics of meningiomas may be suppressed by using antiangiogenic drugs to prevent neovascularization, thus improving prognosis.
doi_str_mv 10.5137/1019-5149.JTN.34777-21.4
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MATERIAL AND METHODSIn this study, in silico analysis of angiogenesis-related gene expression was carried out using previously reported datasets. Messenger ribonucleic acid expressions of VEGFA, VEGFB, PDGFRA, and PDGFRB genes were obtained from two different meningioma transcriptome datasets. The effect of antiangiogenic drugs, bevacizumab and imatinib, on meningiomainduced vascularization was assessed by using rat corneal angiogenesis assay (CAA). RESULTSBevacizumab and imatinib both significantly reduced meningioma-induced neovascularization in the CAA model. 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title Antiangiogenic Molecules Suppressed Meningioma-Induced Neovascularization: A Corneal Angiogenesis Study
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