Identification of molecular initiating events and key events leading to endocrine disrupting effects of PFOA: Integrated molecular dynamic, transcriptomic, and proteomic analyses

Perfluorooctanoic acid (PFOA) can rapidly activate signaling pathways independent of nuclear hormone receptors through membrane receptor regulation, which leads to endocrine disrupting effects. In the present work, the molecular initiating event (MIE) and the key events (KEs) which cause the endocri...

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Veröffentlicht in:	Chemosphere (Oxford) 2022-11, Vol.307, p.135881-135881, Article 135881
Hauptverfasser:	Guan, Ruining, Luan, Feng, Li, Ningqi, Qiu, Zhiqiang, Liu, Wencheng, Cui, Zeyang, Zhao, Chunyan, Li, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	GPER Molecular dynamics Multi-omics Perfluorooctanoic acid (PFOA)
Online-Zugang:	Volltext
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