mTOR participates in the formation, maintenance, and function of memory CD8+T cells regulated by glycometabolism
[Display omitted] Memory CD8+T cells participate in the fight against infection and tumorigenesis as well as in autoimmune disease progression because of their efficient and rapid immune response, long-term survival, and continuous differentiation. At each stage of their formation, maintenance, and...
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| Veröffentlicht in: | Biochemical pharmacology 2022-10, Vol.204, p.115197-115197, Article 115197 |
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| creator | Cai, Xuepei Li, Haokun Wang, Manyi Chu, Edward Wei, Ning Lin, Jiayu Hu, Yun Dai, Jingtao Chen, Aijie Zheng, Hua Zhang, Qianbing Zhong, Yuxia Chang, Ruoshui Wu, Sha Xiao, Yaomu Liu, Chufeng |
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Memory CD8+T cells participate in the fight against infection and tumorigenesis as well as in autoimmune disease progression because of their efficient and rapid immune response, long-term survival, and continuous differentiation. At each stage of their formation, maintenance, and function, the cell metabolism must be adjusted to match the functional requirements of the specific stage. Notably, enhanced glycolytic metabolism can generate sufficient levels of adenosine triphosphate (ATP) to form memory CD8+T cells, countering the view that glycolysis prevents the formation of memory CD8+T cells. This review focuses on how glycometabolism regulates memory CD8+T cells and highlights the key mechanisms through which the mammalian target of rapamycin (mTOR) signaling pathway affects memory CD8+T cell formation, maintenance, and function by regulating glycometabolism. In addition, different subpopulations of memory CD8+T cells exhibit different metabolic flexibility during their formation, survival, and functional stages, during which the energy metabolism may be critical. These findings which may explain why enhanced glycolytic metabolism can give rise to memory CD8+T cells. Modulating the metabolism of memory CD8+T cells to influence specific cell fates may be useful for disease treatment. |
| doi_str_mv | 10.1016/j.bcp.2022.115197 |
| format | Article |
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Memory CD8+T cells participate in the fight against infection and tumorigenesis as well as in autoimmune disease progression because of their efficient and rapid immune response, long-term survival, and continuous differentiation. At each stage of their formation, maintenance, and function, the cell metabolism must be adjusted to match the functional requirements of the specific stage. Notably, enhanced glycolytic metabolism can generate sufficient levels of adenosine triphosphate (ATP) to form memory CD8+T cells, countering the view that glycolysis prevents the formation of memory CD8+T cells. This review focuses on how glycometabolism regulates memory CD8+T cells and highlights the key mechanisms through which the mammalian target of rapamycin (mTOR) signaling pathway affects memory CD8+T cell formation, maintenance, and function by regulating glycometabolism. In addition, different subpopulations of memory CD8+T cells exhibit different metabolic flexibility during their formation, survival, and functional stages, during which the energy metabolism may be critical. These findings which may explain why enhanced glycolytic metabolism can give rise to memory CD8+T cells. Modulating the metabolism of memory CD8+T cells to influence specific cell fates may be useful for disease treatment.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/j.bcp.2022.115197</identifier><identifier>PMID: 35926651</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adenosine Triphosphate - metabolism ; Animals ; CD8-Positive T-Lymphocytes ; Cell Differentiation ; Glycolysis ; Glycometabolism ; Immunologic Memory ; Memory CD8+T cell ; Mice ; Mice, Inbred C57BL ; mTOR ; TOR Serine-Threonine Kinases - metabolism</subject><ispartof>Biochemical pharmacology, 2022-10, Vol.204, p.115197-115197, Article 115197</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c283t-caaaf7b51ddfdb6e0b599099eb8a55508c75feb2e29d30911c6e917ae81326e53</citedby><cites>FETCH-LOGICAL-c283t-caaaf7b51ddfdb6e0b599099eb8a55508c75feb2e29d30911c6e917ae81326e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000629522200291X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35926651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Xuepei</creatorcontrib><creatorcontrib>Li, Haokun</creatorcontrib><creatorcontrib>Wang, Manyi</creatorcontrib><creatorcontrib>Chu, Edward</creatorcontrib><creatorcontrib>Wei, Ning</creatorcontrib><creatorcontrib>Lin, Jiayu</creatorcontrib><creatorcontrib>Hu, Yun</creatorcontrib><creatorcontrib>Dai, Jingtao</creatorcontrib><creatorcontrib>Chen, Aijie</creatorcontrib><creatorcontrib>Zheng, Hua</creatorcontrib><creatorcontrib>Zhang, Qianbing</creatorcontrib><creatorcontrib>Zhong, Yuxia</creatorcontrib><creatorcontrib>Chang, Ruoshui</creatorcontrib><creatorcontrib>Wu, Sha</creatorcontrib><creatorcontrib>Xiao, Yaomu</creatorcontrib><creatorcontrib>Liu, Chufeng</creatorcontrib><title>mTOR participates in the formation, maintenance, and function of memory CD8+T cells regulated by glycometabolism</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>[Display omitted]
Memory CD8+T cells participate in the fight against infection and tumorigenesis as well as in autoimmune disease progression because of their efficient and rapid immune response, long-term survival, and continuous differentiation. At each stage of their formation, maintenance, and function, the cell metabolism must be adjusted to match the functional requirements of the specific stage. Notably, enhanced glycolytic metabolism can generate sufficient levels of adenosine triphosphate (ATP) to form memory CD8+T cells, countering the view that glycolysis prevents the formation of memory CD8+T cells. This review focuses on how glycometabolism regulates memory CD8+T cells and highlights the key mechanisms through which the mammalian target of rapamycin (mTOR) signaling pathway affects memory CD8+T cell formation, maintenance, and function by regulating glycometabolism. In addition, different subpopulations of memory CD8+T cells exhibit different metabolic flexibility during their formation, survival, and functional stages, during which the energy metabolism may be critical. These findings which may explain why enhanced glycolytic metabolism can give rise to memory CD8+T cells. Modulating the metabolism of memory CD8+T cells to influence specific cell fates may be useful for disease treatment.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>Cell Differentiation</subject><subject>Glycolysis</subject><subject>Glycometabolism</subject><subject>Immunologic Memory</subject><subject>Memory CD8+T cell</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>mTOR</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSLZpf0AuQcdCsltJRrJETmXTj0AgULZnoY9xosWyHEkO7L-vzSY99jQzzPu-zDwIXVKyoYSKr_uNdeOGEcY2lHKq2hO0orJt1kwJ-QGtCCFi7jk7Rx9L2S-jFPQMnTdcMSE4XaEx7h5_49HkGlwYTYWCw4DrM-Au5WhqSMMNjiYMFQYzOLjBZvC4mwa3rHDqcISY8gFv7-T1Djvo-4IzPE39nOWxPeCn_uBShGps6kOJn9BpZ_oCn9_qBfrz4_tu-2v98PjzfvvtYe2YbOraGWO61nLqfeetAGK5UkQpsNJwzol0Le_AMmDKN0RR6gQo2hqQtGECeHOBvhxzx5xeJihVx1CW88wAaSqaCaVa0kopZik9Sl1OpWTo9JhDNPmgKdELaL3XM2i9gNZH0LPn6i1-shH8P8c72VlwexTA_ORrgKyLCzAT9CGDq9qn8J_4v4Ddjxk</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Cai, Xuepei</creator><creator>Li, Haokun</creator><creator>Wang, Manyi</creator><creator>Chu, Edward</creator><creator>Wei, Ning</creator><creator>Lin, Jiayu</creator><creator>Hu, Yun</creator><creator>Dai, Jingtao</creator><creator>Chen, Aijie</creator><creator>Zheng, Hua</creator><creator>Zhang, Qianbing</creator><creator>Zhong, Yuxia</creator><creator>Chang, Ruoshui</creator><creator>Wu, Sha</creator><creator>Xiao, Yaomu</creator><creator>Liu, Chufeng</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202210</creationdate><title>mTOR participates in the formation, maintenance, and function of memory CD8+T cells regulated by glycometabolism</title><author>Cai, Xuepei ; Li, Haokun ; Wang, Manyi ; Chu, Edward ; Wei, Ning ; Lin, Jiayu ; Hu, Yun ; Dai, Jingtao ; Chen, Aijie ; Zheng, Hua ; Zhang, Qianbing ; Zhong, Yuxia ; Chang, Ruoshui ; Wu, Sha ; Xiao, Yaomu ; Liu, Chufeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c283t-caaaf7b51ddfdb6e0b599099eb8a55508c75feb2e29d30911c6e917ae81326e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>Cell Differentiation</topic><topic>Glycolysis</topic><topic>Glycometabolism</topic><topic>Immunologic Memory</topic><topic>Memory CD8+T cell</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>mTOR</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Xuepei</creatorcontrib><creatorcontrib>Li, Haokun</creatorcontrib><creatorcontrib>Wang, Manyi</creatorcontrib><creatorcontrib>Chu, Edward</creatorcontrib><creatorcontrib>Wei, Ning</creatorcontrib><creatorcontrib>Lin, Jiayu</creatorcontrib><creatorcontrib>Hu, Yun</creatorcontrib><creatorcontrib>Dai, Jingtao</creatorcontrib><creatorcontrib>Chen, Aijie</creatorcontrib><creatorcontrib>Zheng, Hua</creatorcontrib><creatorcontrib>Zhang, Qianbing</creatorcontrib><creatorcontrib>Zhong, Yuxia</creatorcontrib><creatorcontrib>Chang, Ruoshui</creatorcontrib><creatorcontrib>Wu, Sha</creatorcontrib><creatorcontrib>Xiao, Yaomu</creatorcontrib><creatorcontrib>Liu, Chufeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Xuepei</au><au>Li, Haokun</au><au>Wang, Manyi</au><au>Chu, Edward</au><au>Wei, Ning</au><au>Lin, Jiayu</au><au>Hu, Yun</au><au>Dai, Jingtao</au><au>Chen, Aijie</au><au>Zheng, Hua</au><au>Zhang, Qianbing</au><au>Zhong, Yuxia</au><au>Chang, Ruoshui</au><au>Wu, Sha</au><au>Xiao, Yaomu</au><au>Liu, Chufeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>mTOR participates in the formation, maintenance, and function of memory CD8+T cells regulated by glycometabolism</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>2022-10</date><risdate>2022</risdate><volume>204</volume><spage>115197</spage><epage>115197</epage><pages>115197-115197</pages><artnum>115197</artnum><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>[Display omitted]
Memory CD8+T cells participate in the fight against infection and tumorigenesis as well as in autoimmune disease progression because of their efficient and rapid immune response, long-term survival, and continuous differentiation. At each stage of their formation, maintenance, and function, the cell metabolism must be adjusted to match the functional requirements of the specific stage. Notably, enhanced glycolytic metabolism can generate sufficient levels of adenosine triphosphate (ATP) to form memory CD8+T cells, countering the view that glycolysis prevents the formation of memory CD8+T cells. This review focuses on how glycometabolism regulates memory CD8+T cells and highlights the key mechanisms through which the mammalian target of rapamycin (mTOR) signaling pathway affects memory CD8+T cell formation, maintenance, and function by regulating glycometabolism. In addition, different subpopulations of memory CD8+T cells exhibit different metabolic flexibility during their formation, survival, and functional stages, during which the energy metabolism may be critical. These findings which may explain why enhanced glycolytic metabolism can give rise to memory CD8+T cells. Modulating the metabolism of memory CD8+T cells to influence specific cell fates may be useful for disease treatment.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>35926651</pmid><doi>10.1016/j.bcp.2022.115197</doi><tpages>1</tpages></addata></record> |
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| subjects | Adenosine Triphosphate - metabolism Animals CD8-Positive T-Lymphocytes Cell Differentiation Glycolysis Glycometabolism Immunologic Memory Memory CD8+T cell Mice Mice, Inbred C57BL mTOR TOR Serine-Threonine Kinases - metabolism |
| title | mTOR participates in the formation, maintenance, and function of memory CD8+T cells regulated by glycometabolism |
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