Multiomics characterization of mouse hepatoblastoma identifies yes-associated protein 1 target genes

Hepatoblastoma (HB) is the most common primary liver malignancy in childhood and lacks targeted therapeutic options. We previously engineered, to our knowledge, the first yes-associated protein 1 (YAP1) S127A -inducible mouse model of HB, demonstrating tumor regression and redifferentiation after YA...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2023-07, Vol.78 (1), p.58-71
Hauptverfasser:	Rodríguez, Tomás C, Kwan, Suet-Yan, Smith, Jordan L, Dadafarin, Sina, Wu, Chern-Horng, Sontheimer, Erik J, Xue, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Chromatin Gene Expression Regulation, Neoplastic Hepatoblastoma - genetics Hepatoblastoma - pathology Humans Mice Multiomics Transcription Factors - genetics Transcription Factors - metabolism YAP-Signaling Proteins
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