PCSK9 Promotes Endothelial Dysfunction During Sepsis Via the TLR4/MyD88/NF-κB and NLRP3 Pathways

Endothelial dysfunction often accompanies sepsis. We aimed to explore the role of PCSK9 in septic endothelial dysfunction. Sepsis was induced by lipopolysaccharide (LPS) treatment of human umbilical vein endothelial cells (HUVECs) in vitro and cecal ligation and puncture (CLP) surgery in mice in viv...

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Veröffentlicht in:	Inflammation 2023-02, Vol.46 (1), p.115-128
Hauptverfasser:	Huang, Longxiang, Li, Yuanjing, Cheng, Zhe, Lv, Zi, Luo, Suxin, Xia, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonium Animals Aorta Biomedical and Life Sciences Biomedicine Cadherins Caspase-1 Cecum Endothelial cells Endothelium Gene expression Human Umbilical Vein Endothelial Cells - metabolism Humans Immunohistochemistry Immunology Inflammation Interleukin 18 Internal Medicine Lipid A Lipopolysaccharides Mice MyD88 protein Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism NF-κB protein Nitric oxide NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Original Article Pathology Pharmacology/Toxicology Proprotein Convertase 9 - metabolism Rheumatology Sepsis Sepsis - metabolism Therapeutic targets TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Umbilical vein Vasodilation Western blotting
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