Effect of modification of betulinic acid at the C3-carbon atom of homolupane triterpenoids on the antiproliferative activity in vitro

In search of new cytotoxic derivatives based on the lupane scaffold, methyl betulonate and methyl 20,29-dihydrobetulonate were conjugated with Reformatsky reagents to provide homolupanes extended at the C3-carbon atom. Further transformations of the functional groups afforded a series of derivatives...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2022-11, Vol.224, p.106161, Article 106161
Hauptverfasser:	Rárová, Lucie, Pakulski, Zbigniew, Strnad, Miroslav, Kvasnicová, Marie, Štenclová, Tereza, Cmoch, Piotr
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antiproliferative activity Apoptosis Betulinic Acid Cancer cells Cell Line, Tumor Drug Screening Assays, Antitumor Fibroblasts HeLa Cells Humans Lupanes Reformatsky reaction Structure-Activity Relationship Triterpenes - pharmacology
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