Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment

Microglia-mediated neuroinflammation plays an important role in ischemic stroke (IS). In this work, a series of novel indole and indazole-piperazine pyrimidine derivatives with anti-neuroinflammatory and neuroprotective activities were designed and synthesized for treatment of IS. Among these compou...

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Veröffentlicht in:	European journal of medicinal chemistry 2022-11, Vol.241, p.114597-114597, Article 114597
Hauptverfasser:	Wang, Hongwei, Cui, Enjing, Li, Jiaming, Ma, Xiaodong, Jiang, Xueyang, Du, Shuaishuai, Qian, Shihu, Du, Le
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-neuroinflammation Indole Ischemic stroke Microglia Piperazine pyrimidine
Online-Zugang:	Volltext
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