Base-Promoted 5-exo-dig Cyclization of o‑Alkynylamides or 2‑En-4-ynamides with CO2 toward Fully Substituted Acrylates

A base-promoted sequential cyclization and carboxylation of o-alkynylamides or 2-en-4-ynamides with CO2 has been achieved with high efficiency, stereoselectivity, and regioselectivity. This approach begins with 5-exo-dig cyclization followed by trapping the resulting vinyl anion with CO2 and MeI, wh...

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Veröffentlicht in:	Organic letters 2022-08, Vol.24 (31), p.5715-5720
Hauptverfasser:	Sha, Yu, Bai, Junxue, Li, Miao, Gao, Wanxu, Yang, Qi, Sun, Jianwei, Sun, Song
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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