Fast and Selective Detection of Trace Chemical Warfare Agents Enabled by an ESIPT-Based Fluorescent Film Sensor
Reliable detection of airborne chemical warfare agents (CWAs) at the site and in real-time remains a challenge due to the rarity of miniaturized analytical tools. Herein, an o-carborane-functionalized benzothiazole derivative (PCBO) with excited-state intramolecular proton transfer (ESIPT) and AIE c...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2022-08, Vol.94 (32), p.11151-11158 |
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| creator | Liu, Ke Qin, Molin Shi, Qiyuan Wang, Gang Zhang, Jing Ding, Nannan Xi, Hailing Liu, Taihong Kong, Jinglin Fang, Yu |
| description | Reliable detection of airborne chemical warfare agents (CWAs) at the site and in real-time remains a challenge due to the rarity of miniaturized analytical tools. Herein, an o-carborane-functionalized benzothiazole derivative (PCBO) with excited-state intramolecular proton transfer (ESIPT) and AIE characteristics was synthesized. The PCBO-based film sensor showed a highly sensitive response to representative simulants of CWAs, and detection limits were found to be 1.0 mg·m–3 for triphosgene, 6.0 mg·m–3 for chloroethyl ethyl sulfide, and 0.2 mg·m–3 for diethyl chlorophosphite. Moreover, the sensor showed great reusability (>100 cycles) and unprecedented response speed ( |
| doi_str_mv | 10.1021/acs.analchem.2c00862 |
| format | Article |
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Herein, an o-carborane-functionalized benzothiazole derivative (PCBO) with excited-state intramolecular proton transfer (ESIPT) and AIE characteristics was synthesized. The PCBO-based film sensor showed a highly sensitive response to representative simulants of CWAs, and detection limits were found to be 1.0 mg·m–3 for triphosgene, 6.0 mg·m–3 for chloroethyl ethyl sulfide, and 0.2 mg·m–3 for diethyl chlorophosphite. Moreover, the sensor showed great reusability (>100 cycles) and unprecedented response speed (<0.5 s). The excellent sensing performance was ascribed to the microenvironmental sensitivity of the sensing fluorophore, the porous adlayer structure of the film, and the specific binding of the fluorophore to the analytes. Furthermore, discrimination and identification of the examined CWA simulants were realized via the introduction of another fluorophore (HCBO)-based film. Importantly, a portable fluorescent CWA detector was built with the sensor as the key component, and its applicability was demonstrated by the successful detection of a typical CWA sample (Sarin). The present study indicates that fluorescent film sensors could satisfy reliable onsite and real-time detection of harmful chemicals.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.2c00862</identifier><language>eng</language><publisher>Washington: American Chemical Society</publisher><subject>Air pollution ; Airborne sensing ; Benzothiazole ; Carborane ; Chemical warfare ; Chemical warfare agents ; Chemistry ; Detection limits ; Fluorescence ; Real time ; Sarin ; Sensors</subject><ispartof>Analytical chemistry (Washington), 2022-08, Vol.94 (32), p.11151-11158</ispartof><rights>2022 American Chemical Society</rights><rights>Copyright American Chemical Society Aug 16, 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a353t-c4fa005109beb792de737944e459b2394c2a29cbe258fb269b2cdc496d1b72323</citedby><cites>FETCH-LOGICAL-a353t-c4fa005109beb792de737944e459b2394c2a29cbe258fb269b2cdc496d1b72323</cites><orcidid>0000-0002-9600-1045 ; 0000-0001-8490-8080</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.2c00862$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.2c00862$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids></links><search><creatorcontrib>Liu, Ke</creatorcontrib><creatorcontrib>Qin, Molin</creatorcontrib><creatorcontrib>Shi, Qiyuan</creatorcontrib><creatorcontrib>Wang, Gang</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Ding, Nannan</creatorcontrib><creatorcontrib>Xi, Hailing</creatorcontrib><creatorcontrib>Liu, Taihong</creatorcontrib><creatorcontrib>Kong, Jinglin</creatorcontrib><creatorcontrib>Fang, Yu</creatorcontrib><title>Fast and Selective Detection of Trace Chemical Warfare Agents Enabled by an ESIPT-Based Fluorescent Film Sensor</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>Reliable detection of airborne chemical warfare agents (CWAs) at the site and in real-time remains a challenge due to the rarity of miniaturized analytical tools. Herein, an o-carborane-functionalized benzothiazole derivative (PCBO) with excited-state intramolecular proton transfer (ESIPT) and AIE characteristics was synthesized. The PCBO-based film sensor showed a highly sensitive response to representative simulants of CWAs, and detection limits were found to be 1.0 mg·m–3 for triphosgene, 6.0 mg·m–3 for chloroethyl ethyl sulfide, and 0.2 mg·m–3 for diethyl chlorophosphite. Moreover, the sensor showed great reusability (>100 cycles) and unprecedented response speed (<0.5 s). The excellent sensing performance was ascribed to the microenvironmental sensitivity of the sensing fluorophore, the porous adlayer structure of the film, and the specific binding of the fluorophore to the analytes. Furthermore, discrimination and identification of the examined CWA simulants were realized via the introduction of another fluorophore (HCBO)-based film. Importantly, a portable fluorescent CWA detector was built with the sensor as the key component, and its applicability was demonstrated by the successful detection of a typical CWA sample (Sarin). The present study indicates that fluorescent film sensors could satisfy reliable onsite and real-time detection of harmful chemicals.</description><subject>Air pollution</subject><subject>Airborne sensing</subject><subject>Benzothiazole</subject><subject>Carborane</subject><subject>Chemical warfare</subject><subject>Chemical warfare agents</subject><subject>Chemistry</subject><subject>Detection limits</subject><subject>Fluorescence</subject><subject>Real time</subject><subject>Sarin</subject><subject>Sensors</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kctKAzEUhoMoWC9v4CLgxs3Uk8vcllpbLQgKVlwOZzJndEo60WQq9O1Nqbpw4Srh5Ps_DvkZOxMwFiDFJZowxh6teaPVWBqAIpN7bCRSCUlWFHKfjQBAJTIHOGRHISwBhACRjZibYRg49g1_Iktm6D6J39Cwvbmeu5YvPBrik2juDFr-gr5FT_zqlfoh8GmPtaWG15vo4NOn-eMiucYQJzO7dp6CiRifdXYV_X1w_oQdtGgDnX6fx-x5Nl1M7pL7h9v55Oo-QZWqITG6RYBUQFlTnZeyoVzlpdak07KWqtRGoixNTTIt2lpmcWgao8usEXUulVTH7GLnfffuY01hqFZdXMZa7MmtQxUjRaZkLvKInv9Bl27t43dGKodUa6XTLFJ6RxnvQvDUVu--W6HfVAKqbQtVbKH6aaH6biHGYBfbvv56_418AT3RjQQ</recordid><startdate>20220816</startdate><enddate>20220816</enddate><creator>Liu, Ke</creator><creator>Qin, Molin</creator><creator>Shi, Qiyuan</creator><creator>Wang, Gang</creator><creator>Zhang, Jing</creator><creator>Ding, Nannan</creator><creator>Xi, Hailing</creator><creator>Liu, Taihong</creator><creator>Kong, Jinglin</creator><creator>Fang, Yu</creator><general>American Chemical Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9600-1045</orcidid><orcidid>https://orcid.org/0000-0001-8490-8080</orcidid></search><sort><creationdate>20220816</creationdate><title>Fast and Selective Detection of Trace Chemical Warfare Agents Enabled by an ESIPT-Based Fluorescent Film Sensor</title><author>Liu, Ke ; Qin, Molin ; Shi, Qiyuan ; Wang, Gang ; Zhang, Jing ; Ding, Nannan ; Xi, Hailing ; Liu, Taihong ; Kong, Jinglin ; Fang, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a353t-c4fa005109beb792de737944e459b2394c2a29cbe258fb269b2cdc496d1b72323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Air pollution</topic><topic>Airborne sensing</topic><topic>Benzothiazole</topic><topic>Carborane</topic><topic>Chemical warfare</topic><topic>Chemical warfare agents</topic><topic>Chemistry</topic><topic>Detection limits</topic><topic>Fluorescence</topic><topic>Real time</topic><topic>Sarin</topic><topic>Sensors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ke</creatorcontrib><creatorcontrib>Qin, Molin</creatorcontrib><creatorcontrib>Shi, Qiyuan</creatorcontrib><creatorcontrib>Wang, Gang</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Ding, Nannan</creatorcontrib><creatorcontrib>Xi, Hailing</creatorcontrib><creatorcontrib>Liu, Taihong</creatorcontrib><creatorcontrib>Kong, Jinglin</creatorcontrib><creatorcontrib>Fang, Yu</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ke</au><au>Qin, Molin</au><au>Shi, Qiyuan</au><au>Wang, Gang</au><au>Zhang, Jing</au><au>Ding, Nannan</au><au>Xi, Hailing</au><au>Liu, Taihong</au><au>Kong, Jinglin</au><au>Fang, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fast and Selective Detection of Trace Chemical Warfare Agents Enabled by an ESIPT-Based Fluorescent Film Sensor</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2022-08-16</date><risdate>2022</risdate><volume>94</volume><issue>32</issue><spage>11151</spage><epage>11158</epage><pages>11151-11158</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><abstract>Reliable detection of airborne chemical warfare agents (CWAs) at the site and in real-time remains a challenge due to the rarity of miniaturized analytical tools. Herein, an o-carborane-functionalized benzothiazole derivative (PCBO) with excited-state intramolecular proton transfer (ESIPT) and AIE characteristics was synthesized. The PCBO-based film sensor showed a highly sensitive response to representative simulants of CWAs, and detection limits were found to be 1.0 mg·m–3 for triphosgene, 6.0 mg·m–3 for chloroethyl ethyl sulfide, and 0.2 mg·m–3 for diethyl chlorophosphite. Moreover, the sensor showed great reusability (>100 cycles) and unprecedented response speed (<0.5 s). The excellent sensing performance was ascribed to the microenvironmental sensitivity of the sensing fluorophore, the porous adlayer structure of the film, and the specific binding of the fluorophore to the analytes. Furthermore, discrimination and identification of the examined CWA simulants were realized via the introduction of another fluorophore (HCBO)-based film. Importantly, a portable fluorescent CWA detector was built with the sensor as the key component, and its applicability was demonstrated by the successful detection of a typical CWA sample (Sarin). The present study indicates that fluorescent film sensors could satisfy reliable onsite and real-time detection of harmful chemicals.</abstract><cop>Washington</cop><pub>American Chemical Society</pub><doi>10.1021/acs.analchem.2c00862</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9600-1045</orcidid><orcidid>https://orcid.org/0000-0001-8490-8080</orcidid></addata></record> |
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| source | American Chemical Society Journals |
| subjects | Air pollution Airborne sensing Benzothiazole Carborane Chemical warfare Chemical warfare agents Chemistry Detection limits Fluorescence Real time Sarin Sensors |
| title | Fast and Selective Detection of Trace Chemical Warfare Agents Enabled by an ESIPT-Based Fluorescent Film Sensor |
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