Posttreatment FDG‐PET/CT Hopkins criteria predict locoregional recurrence after definitive radiotherapy for oropharyngeal squamous cell carcinoma
Background Metabolic response assessment for oropharyngeal squamous cell carcinoma (OPSCC) aids in identifying locoregional persistence/recurrence (LRR). The Hopkins Criteria are a standardized qualitative response assessment system using posttreatment FDG‐PET/CT. Methods We conducted a retrospectiv...
Gespeichert in:
| Veröffentlicht in: | Head & neck 2022-11, Vol.44 (11), p.2491-2504 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2504 |
|---|---|
| container_issue | 11 |
| container_start_page | 2491 |
| container_title | Head & neck |
| container_volume | 44 |
| creator | Miller, Jacob A. Moradi, Farshad Sundaram, Vandana Liang, Rachel Zhang, Carrie Nguyen, Ngan Kim Akhtar, Faisal Liu, Yuhan Ren, Yulan Harandi, Nima Weng, Yingjie Pollom, Erqi L. Colevas, Alexander Dimitrios Divi, Vasu Holsinger, Floyd Christopher Beadle, Beth M. Le, Quynh‐Thu Gensheimer, Michael F. |
| description | Background
Metabolic response assessment for oropharyngeal squamous cell carcinoma (OPSCC) aids in identifying locoregional persistence/recurrence (LRR). The Hopkins Criteria are a standardized qualitative response assessment system using posttreatment FDG‐PET/CT.
Methods
We conducted a retrospective cohort study of patients with node‐positive OPSCC treated with definitive (chemo)radiotherapy. We assessed Hopkins Criteria performance for LRR, then developed and validated a competing‐risks model.
Results
Between 2004 and 2018, 259 patients were included with median follow‐up of 43 months. The Hopkins Criteria sensitivity, specificity, negative predictive value, and accuracy were 68%, 88%, 95%, and 85%. The 36‐month cumulative incidence of LRR was greater with positive scores (45% vs. 5%, HR 12.60, p |
| doi_str_mv | 10.1002/hed.27160 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2697674826</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2697674826</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3300-8b2e9654ccdd9f7db6c8eb5e81b2d5bb7e38d45ef71973d5caf2ce1ce5ab67c13</originalsourceid><addsrcrecordid>eNp1kc1O3DAUhaOKSgXaRd_AEhtYhPFPYidLNAxMJaSymK4jx75hTJM4XDtUs-sjVOob8iR4OqyQurp38Z1zz9XJsq-MXjJK-WIL9pIrJumH7JjRWuVUFOpovxciF1QVn7KTEB4ppUIW_Dj7e-9DjAg6DjBGcnN9-_L7z_1qs1huyNpPP90YiEEXAZ0mE4J1JpLeG4_w4Pyoe4JgZkQYDRDdJY5Y6NzoonsGgto6H7eAetqRziPx6Ketxt34AEkanmY9-DldgL4nRqNxox_05-xjp_sAX97mafbjZrVZrvO777fflld3uRGC0rxqOdSyLIyxtu6UbaWpoC2hYi23ZdsqEJUtSugUq5WwpdEdN8AMlLqVyjBxmp0ffCf0TzOE2Awu7KPoEVKqhstaSVVUXCb07B366GdM7ydKcS4Zr8q94cWBMuhDQOiaCd2Q3m0Ybfb1NKme5l89iV0c2F-uh93_wWa9uj4oXgEagpZU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2722612851</pqid></control><display><type>article</type><title>Posttreatment FDG‐PET/CT Hopkins criteria predict locoregional recurrence after definitive radiotherapy for oropharyngeal squamous cell carcinoma</title><source>Wiley Online Library</source><creator>Miller, Jacob A. ; Moradi, Farshad ; Sundaram, Vandana ; Liang, Rachel ; Zhang, Carrie ; Nguyen, Ngan Kim ; Akhtar, Faisal ; Liu, Yuhan ; Ren, Yulan ; Harandi, Nima ; Weng, Yingjie ; Pollom, Erqi L. ; Colevas, Alexander Dimitrios ; Divi, Vasu ; Holsinger, Floyd Christopher ; Beadle, Beth M. ; Le, Quynh‐Thu ; Gensheimer, Michael F.</creator><creatorcontrib>Miller, Jacob A. ; Moradi, Farshad ; Sundaram, Vandana ; Liang, Rachel ; Zhang, Carrie ; Nguyen, Ngan Kim ; Akhtar, Faisal ; Liu, Yuhan ; Ren, Yulan ; Harandi, Nima ; Weng, Yingjie ; Pollom, Erqi L. ; Colevas, Alexander Dimitrios ; Divi, Vasu ; Holsinger, Floyd Christopher ; Beadle, Beth M. ; Le, Quynh‐Thu ; Gensheimer, Michael F.</creatorcontrib><description>Background
Metabolic response assessment for oropharyngeal squamous cell carcinoma (OPSCC) aids in identifying locoregional persistence/recurrence (LRR). The Hopkins Criteria are a standardized qualitative response assessment system using posttreatment FDG‐PET/CT.
Methods
We conducted a retrospective cohort study of patients with node‐positive OPSCC treated with definitive (chemo)radiotherapy. We assessed Hopkins Criteria performance for LRR, then developed and validated a competing‐risks model.
Results
Between 2004 and 2018, 259 patients were included with median follow‐up of 43 months. The Hopkins Criteria sensitivity, specificity, negative predictive value, and accuracy were 68%, 88%, 95%, and 85%. The 36‐month cumulative incidence of LRR was greater with positive scores (45% vs. 5%, HR 12.60, p < 0.001). PET/CTs performed ≤10 weeks after radiotherapy were associated with a four‐fold increase in pathologically negative biopsies/surgeries (36% vs. 9%, p = 0.03). The AUC for LRR was 0.89 using a model integrating the Hopkins score.
Conclusions
The Hopkins Criteria predict LRR with high accuracy for OPSCC response assessment.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.27160</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Biopsy ; Head & neck cancer ; Hopkins criteria ; locoregional recurrence ; Metabolic response ; oropharynx cancer ; Patients ; PET/CT ; Radiation therapy ; response assessment ; Squamous cell carcinoma ; Throat cancer</subject><ispartof>Head & neck, 2022-11, Vol.44 (11), p.2491-2504</ispartof><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3300-8b2e9654ccdd9f7db6c8eb5e81b2d5bb7e38d45ef71973d5caf2ce1ce5ab67c13</citedby><cites>FETCH-LOGICAL-c3300-8b2e9654ccdd9f7db6c8eb5e81b2d5bb7e38d45ef71973d5caf2ce1ce5ab67c13</cites><orcidid>0000-0001-5497-2831 ; 0000-0002-8480-5492</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.27160$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.27160$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Miller, Jacob A.</creatorcontrib><creatorcontrib>Moradi, Farshad</creatorcontrib><creatorcontrib>Sundaram, Vandana</creatorcontrib><creatorcontrib>Liang, Rachel</creatorcontrib><creatorcontrib>Zhang, Carrie</creatorcontrib><creatorcontrib>Nguyen, Ngan Kim</creatorcontrib><creatorcontrib>Akhtar, Faisal</creatorcontrib><creatorcontrib>Liu, Yuhan</creatorcontrib><creatorcontrib>Ren, Yulan</creatorcontrib><creatorcontrib>Harandi, Nima</creatorcontrib><creatorcontrib>Weng, Yingjie</creatorcontrib><creatorcontrib>Pollom, Erqi L.</creatorcontrib><creatorcontrib>Colevas, Alexander Dimitrios</creatorcontrib><creatorcontrib>Divi, Vasu</creatorcontrib><creatorcontrib>Holsinger, Floyd Christopher</creatorcontrib><creatorcontrib>Beadle, Beth M.</creatorcontrib><creatorcontrib>Le, Quynh‐Thu</creatorcontrib><creatorcontrib>Gensheimer, Michael F.</creatorcontrib><title>Posttreatment FDG‐PET/CT Hopkins criteria predict locoregional recurrence after definitive radiotherapy for oropharyngeal squamous cell carcinoma</title><title>Head & neck</title><description>Background
Metabolic response assessment for oropharyngeal squamous cell carcinoma (OPSCC) aids in identifying locoregional persistence/recurrence (LRR). The Hopkins Criteria are a standardized qualitative response assessment system using posttreatment FDG‐PET/CT.
Methods
We conducted a retrospective cohort study of patients with node‐positive OPSCC treated with definitive (chemo)radiotherapy. We assessed Hopkins Criteria performance for LRR, then developed and validated a competing‐risks model.
Results
Between 2004 and 2018, 259 patients were included with median follow‐up of 43 months. The Hopkins Criteria sensitivity, specificity, negative predictive value, and accuracy were 68%, 88%, 95%, and 85%. The 36‐month cumulative incidence of LRR was greater with positive scores (45% vs. 5%, HR 12.60, p < 0.001). PET/CTs performed ≤10 weeks after radiotherapy were associated with a four‐fold increase in pathologically negative biopsies/surgeries (36% vs. 9%, p = 0.03). The AUC for LRR was 0.89 using a model integrating the Hopkins score.
Conclusions
The Hopkins Criteria predict LRR with high accuracy for OPSCC response assessment.</description><subject>Biopsy</subject><subject>Head & neck cancer</subject><subject>Hopkins criteria</subject><subject>locoregional recurrence</subject><subject>Metabolic response</subject><subject>oropharynx cancer</subject><subject>Patients</subject><subject>PET/CT</subject><subject>Radiation therapy</subject><subject>response assessment</subject><subject>Squamous cell carcinoma</subject><subject>Throat cancer</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kc1O3DAUhaOKSgXaRd_AEhtYhPFPYidLNAxMJaSymK4jx75hTJM4XDtUs-sjVOob8iR4OqyQurp38Z1zz9XJsq-MXjJK-WIL9pIrJumH7JjRWuVUFOpovxciF1QVn7KTEB4ppUIW_Dj7e-9DjAg6DjBGcnN9-_L7z_1qs1huyNpPP90YiEEXAZ0mE4J1JpLeG4_w4Pyoe4JgZkQYDRDdJY5Y6NzoonsGgto6H7eAetqRziPx6Ketxt34AEkanmY9-DldgL4nRqNxox_05-xjp_sAX97mafbjZrVZrvO777fflld3uRGC0rxqOdSyLIyxtu6UbaWpoC2hYi23ZdsqEJUtSugUq5WwpdEdN8AMlLqVyjBxmp0ffCf0TzOE2Awu7KPoEVKqhstaSVVUXCb07B366GdM7ydKcS4Zr8q94cWBMuhDQOiaCd2Q3m0Ybfb1NKme5l89iV0c2F-uh93_wWa9uj4oXgEagpZU</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Miller, Jacob A.</creator><creator>Moradi, Farshad</creator><creator>Sundaram, Vandana</creator><creator>Liang, Rachel</creator><creator>Zhang, Carrie</creator><creator>Nguyen, Ngan Kim</creator><creator>Akhtar, Faisal</creator><creator>Liu, Yuhan</creator><creator>Ren, Yulan</creator><creator>Harandi, Nima</creator><creator>Weng, Yingjie</creator><creator>Pollom, Erqi L.</creator><creator>Colevas, Alexander Dimitrios</creator><creator>Divi, Vasu</creator><creator>Holsinger, Floyd Christopher</creator><creator>Beadle, Beth M.</creator><creator>Le, Quynh‐Thu</creator><creator>Gensheimer, Michael F.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5497-2831</orcidid><orcidid>https://orcid.org/0000-0002-8480-5492</orcidid></search><sort><creationdate>202211</creationdate><title>Posttreatment FDG‐PET/CT Hopkins criteria predict locoregional recurrence after definitive radiotherapy for oropharyngeal squamous cell carcinoma</title><author>Miller, Jacob A. ; Moradi, Farshad ; Sundaram, Vandana ; Liang, Rachel ; Zhang, Carrie ; Nguyen, Ngan Kim ; Akhtar, Faisal ; Liu, Yuhan ; Ren, Yulan ; Harandi, Nima ; Weng, Yingjie ; Pollom, Erqi L. ; Colevas, Alexander Dimitrios ; Divi, Vasu ; Holsinger, Floyd Christopher ; Beadle, Beth M. ; Le, Quynh‐Thu ; Gensheimer, Michael F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3300-8b2e9654ccdd9f7db6c8eb5e81b2d5bb7e38d45ef71973d5caf2ce1ce5ab67c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biopsy</topic><topic>Head & neck cancer</topic><topic>Hopkins criteria</topic><topic>locoregional recurrence</topic><topic>Metabolic response</topic><topic>oropharynx cancer</topic><topic>Patients</topic><topic>PET/CT</topic><topic>Radiation therapy</topic><topic>response assessment</topic><topic>Squamous cell carcinoma</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Jacob A.</creatorcontrib><creatorcontrib>Moradi, Farshad</creatorcontrib><creatorcontrib>Sundaram, Vandana</creatorcontrib><creatorcontrib>Liang, Rachel</creatorcontrib><creatorcontrib>Zhang, Carrie</creatorcontrib><creatorcontrib>Nguyen, Ngan Kim</creatorcontrib><creatorcontrib>Akhtar, Faisal</creatorcontrib><creatorcontrib>Liu, Yuhan</creatorcontrib><creatorcontrib>Ren, Yulan</creatorcontrib><creatorcontrib>Harandi, Nima</creatorcontrib><creatorcontrib>Weng, Yingjie</creatorcontrib><creatorcontrib>Pollom, Erqi L.</creatorcontrib><creatorcontrib>Colevas, Alexander Dimitrios</creatorcontrib><creatorcontrib>Divi, Vasu</creatorcontrib><creatorcontrib>Holsinger, Floyd Christopher</creatorcontrib><creatorcontrib>Beadle, Beth M.</creatorcontrib><creatorcontrib>Le, Quynh‐Thu</creatorcontrib><creatorcontrib>Gensheimer, Michael F.</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Jacob A.</au><au>Moradi, Farshad</au><au>Sundaram, Vandana</au><au>Liang, Rachel</au><au>Zhang, Carrie</au><au>Nguyen, Ngan Kim</au><au>Akhtar, Faisal</au><au>Liu, Yuhan</au><au>Ren, Yulan</au><au>Harandi, Nima</au><au>Weng, Yingjie</au><au>Pollom, Erqi L.</au><au>Colevas, Alexander Dimitrios</au><au>Divi, Vasu</au><au>Holsinger, Floyd Christopher</au><au>Beadle, Beth M.</au><au>Le, Quynh‐Thu</au><au>Gensheimer, Michael F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Posttreatment FDG‐PET/CT Hopkins criteria predict locoregional recurrence after definitive radiotherapy for oropharyngeal squamous cell carcinoma</atitle><jtitle>Head & neck</jtitle><date>2022-11</date><risdate>2022</risdate><volume>44</volume><issue>11</issue><spage>2491</spage><epage>2504</epage><pages>2491-2504</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Metabolic response assessment for oropharyngeal squamous cell carcinoma (OPSCC) aids in identifying locoregional persistence/recurrence (LRR). The Hopkins Criteria are a standardized qualitative response assessment system using posttreatment FDG‐PET/CT.
Methods
We conducted a retrospective cohort study of patients with node‐positive OPSCC treated with definitive (chemo)radiotherapy. We assessed Hopkins Criteria performance for LRR, then developed and validated a competing‐risks model.
Results
Between 2004 and 2018, 259 patients were included with median follow‐up of 43 months. The Hopkins Criteria sensitivity, specificity, negative predictive value, and accuracy were 68%, 88%, 95%, and 85%. The 36‐month cumulative incidence of LRR was greater with positive scores (45% vs. 5%, HR 12.60, p < 0.001). PET/CTs performed ≤10 weeks after radiotherapy were associated with a four‐fold increase in pathologically negative biopsies/surgeries (36% vs. 9%, p = 0.03). The AUC for LRR was 0.89 using a model integrating the Hopkins score.
Conclusions
The Hopkins Criteria predict LRR with high accuracy for OPSCC response assessment.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/hed.27160</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5497-2831</orcidid><orcidid>https://orcid.org/0000-0002-8480-5492</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 2022-11, Vol.44 (11), p.2491-2504 |
| issn | 1043-3074 1097-0347 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2697674826 |
| source | Wiley Online Library |
| subjects | Biopsy Head & neck cancer Hopkins criteria locoregional recurrence Metabolic response oropharynx cancer Patients PET/CT Radiation therapy response assessment Squamous cell carcinoma Throat cancer |
| title | Posttreatment FDG‐PET/CT Hopkins criteria predict locoregional recurrence after definitive radiotherapy for oropharyngeal squamous cell carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T16%3A30%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Posttreatment%20FDG%E2%80%90PET/CT%20Hopkins%20criteria%20predict%20locoregional%20recurrence%20after%20definitive%20radiotherapy%20for%20oropharyngeal%20squamous%20cell%20carcinoma&rft.jtitle=Head%20&%20neck&rft.au=Miller,%20Jacob%20A.&rft.date=2022-11&rft.volume=44&rft.issue=11&rft.spage=2491&rft.epage=2504&rft.pages=2491-2504&rft.issn=1043-3074&rft.eissn=1097-0347&rft_id=info:doi/10.1002/hed.27160&rft_dat=%3Cproquest_cross%3E2697674826%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2722612851&rft_id=info:pmid/&rfr_iscdi=true |