Mass spectrometry–guided discovery of new analogs of bicyclic phosphotriester salinipostin and evaluation of their monoacylglycerol lipase inhibitory activity

Natural products containing the highly unusual phosphotriester ring are known to be potent serine hydrolase inhibitors. The long-chain bicyclic enol-phosphotriester salinipostins (SPTs) from the marine actinomycete Salinispora have been identified as selective antimalarial agents. A potential regula...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2022-09, Vol.86 (10), p.1333-1342
Hauptverfasser:	Kudo, Yuta, Konoki, Keiichi, Yotsu-Yamashita, Mari
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!