Chemistries of bifunctional PROTAC degraders

Proteolysis targeting chimeras (PROTACs) technology is a novel and promising therapeutic strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has received extensive attention from both academia and industry as it can potentially access previously inaccessible targ...

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Veröffentlicht in:	Chemical Society reviews 2022-08, Vol.51 (16), p.766-7114
Hauptverfasser:	Cao, Chaoguo, He, Ming, Wang, Liguo, He, Yuna, Rao, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Design optimization Error analysis
Online-Zugang:	Volltext
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